The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses

The p53 tumour suppressor is a transcription factor that can increase the expression of mRNAs and microRNAs (miRNAs). HT29-tsp53 cells expressing a temperature sensitive variant of p53 have provided a useful model to rapidly and reversibly control p53 activity. In this model, the majority of p53-res...

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Bibliographic Details
Published in:	Gene Vol. 608; pp. 86 - 94
Main Authors:	Cabrita, Miguel A., Bose, Reetesh, Vanzyl, Erin J., Pastic, Alyssa, Marcellus, Kristen A., Pan, Elysia, Hamill, Jeff D., McKay, Bruce C.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-04-2017
Subjects:	BTG2 CDKN1A Cell Line, Tumor Gene Expression Profiling Gene Expression Regulation, Neoplastic HT29 Cells Humans Mdm2 Microarray Microarray Analysis MicroRNA MicroRNAs - genetics MicroRNAs - physiology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptional Activation - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology MRE BTG2 CDKN1A MicroRNA qRT-PCR Mdm2 miRNA pri-miRNA Microarray miRISC
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