Exploiting the preferential phagocytic uptake of nanoparticle-antigen conjugates for the effective treatment of autoimmunity

Tolerance induction is central to the suppression of autoimmunity. Here, we engineered the preferential uptake of nano-conjugated autoantigens by spleen-resident macrophages to re-introduce self-tolerance and suppress autoimmunity. The brain autoantigen, myelin oligodendrocyte glycoprotein (MOG), wa...

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Bibliographic Details
Published in:	Nanomedicine Vol. 40; p. 102481
Main Authors:	Sadanandan, Prashant, Payne, Natalie L., Sun, Guizhi, Ashokan, Anusha, Gowd, Siddaramana G., Lal, Arsha, Satheesh Kumar, Madathiparambil Kumaran, Pulakkat, Sreeranjini, Nair, Shantikumar V., Menon, Krishnakumar N., Bernard, Claude C.A., Koyakutty, Manzoor
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2022
Subjects:	Animals Autoimmunity Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Experimental autoimmune encephalomyelitis Mice Mice, Inbred C57BL Mononuclear phagocytic system Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - pathology Myelin oligodendrocyte glycoprotein Myelin-Oligodendrocyte Glycoprotein - therapeutic use Nanoparticles Silica nanoparticles Silica nanoparticles Experimental autoimmune encephalomyelitis Multiple sclerosis Mononuclear phagocytic system Myelin oligodendrocyte glycoprotein
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