Lactation induces increases in the RANK/RANKL/OPG system in maxillary bone

The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remod...

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Bibliographic Details
Published in:	Bone (New York, N.Y.) Vol. 110; pp. 160 - 169
Main Authors:	Macari, Soraia, Sharma, Lavanya A., Wyatt, Amanda, da Silva, Janine Maíra, Dias, George J., Silva, Tarcília A., Szawka, Raphael E., Grattan, David R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-05-2018
Subjects:	Alveolar bone Animals Bone Diseases, Metabolic - metabolism Bone Remodeling Cell Differentiation Female Lactation Maxilla - diagnostic imaging Maxilla - metabolism Mice Mice, Inbred C57BL Osteoblasts - metabolism Osteoclasts - metabolism Osteoprotegerin Osteoprotegerin - metabolism Phenotype Prolactin - metabolism RANK RANK Ligand - metabolism RANKL Receptor Activator of Nuclear Factor-kappa B - metabolism X-Ray Microtomography RANKL RANK Bone remodeling Lactation Alveolar bone Osteoprotegerin
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