Interleukin-12p40 variant form reduces Interleukin-12p80 secretion

•An IL-12p40 variant form was discovered.•The Il12b variant is expressed in activated BMDCs and some lymphoid tissues.•The IL-12p40 variant form suppresses the formation and secretion of IL-12p80. IL-12 is a key cytokine for the promotion of CD4+ T cells differentiation to type 1 helper T cells. IL-...

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Bibliographic Details

Published in:	Cytokine (Philadelphia, Pa.) Vol. 120; pp. 251 - 257
Main Authors:	Oshikiri, Yumi, Nara, Hidetoshi, Takeda, Yuji, Araki, Akemi, Nemoto, Nobuhito, Gazi, Md. Yeashin, Saito, Shoko, Saitoh, Shinichi, Nakajima, Osamu, Asao, Hironobu
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2019
Subjects:	IL-12p40 IL-12p80 Interleukin-12 Splice variant Splice variant IFN-γ IL-12p40 BMDC Interleukin-12 IL-12p80 IL-12 LPS
Online Access:	Get full text
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