Effect of protease class-specific inhibitors on in vitro development of the third- to fourth-stage larvae of Ascaris suum

Third-stage larvae (L3) of Ascaris suum develop and molt to fourth-stage larvae (L4) during in vitro cultivation; consistently greater than 80% of the larvae develop to L4 during 7 days in culture (DIC). To assess the role of proteases in this process, the effect of protease class-specific inhibitor...

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Bibliographic Details
Published in:	The Journal of parasitology Vol. 84; no. 4; pp. 686 - 690
Main Authors:	Rhoads, M.L. (Parasite Biology and Epidemiology Laboratory, USDA, ARS, Beltsville, MD.), Fetterer, R.H, Urban, J.F. Jr
Format:	Journal Article
Language:	English
Published:	Lawrence, KS American Society of Parasitologists 01-08-1998
Subjects:	AMINOPEPTIDASA AMINOPEPTIDASE Animals Anti-Bacterial Agents - pharmacology ASCARIS SUUM Ascaris suum - drug effects Ascaris suum - enzymology Ascaris suum - growth & development ASPARTIC PROTEINASES Biological and medical sciences BIOLOGICAL DEVELOPMENT Coloring Agents - chemistry Cysteine proteinase inhibitors Cysteine Proteinase Inhibitors - pharmacology CYSTEINE PROTEINASES DESARROLLO BIOLOGICO Development DEVELOPPEMENT BIOLOGIQUE Dipeptides - pharmacology Dose-Response Relationship, Drug Enzymes EXPERIMENTACION IN VITRO EXPERIMENTATION IN VITRO Fundamental and applied biological sciences. Psychology IN VITRO EXPERIMENTATION INHIBIDORES DE PROTEINASAS INHIBITEUR DE PROTEINASES Intestinal volvulus Invertebrates Ketones Ketones - pharmacology Larva - drug effects Larva - growth & development LARVAE Larval development LARVAS LARVE Life cycle. Embryology. Development Molting MOULTING Movement - drug effects MUDA MUE Nemathelminthia. Plathelmintha NEMATODA Nematode larvae Nematodes Parasitology Pepstatins - pharmacology Peptides Physiology. Development PROTEASAS PROTEASE Protease Inhibitors - pharmacology PROTEASES PROTEINASE INHIBITORS Sulfones - pharmacology Swine Tetrazolium Salts - chemistry Thiazoles - chemistry Trypsin Inhibitors - pharmacology Life history Cysteine Enzyme Aminopeptidases Serine Enzyme inhibitor Parasite Experimental study In vitro Molt Peptidases Larva Helmintha Ascaris suum Development Hydrolases Nemathelminthia Aspartic acid Invertebrata Nematoda
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