Effects of insulin infusion on endothelium-derived vasoactive substances

An association between insulin resistance and hypertension has been reported in several studies. In apparent contradiction, insulin infusion in healthy volunteers is associated with vasodilatation. Furthermore, there is evidence that some insulin effects may differ between the sexes. We performed th...

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Bibliographic Details
Published in:	Diabetologia Vol. 39; no. 11; pp. 1284 - 1292
Main Authors:	POLDERMAN, K. H, STEHOUWER, C. D. A, VAN KAMP, G. J, GOOREN, L. J. G
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-11-1996
Subjects:	6-Ketoprostaglandin F1 alpha - metabolism 6-Ketoprostaglandin F1 alpha - urine Adolescent Adult Amino Acids - blood Amino Acids - drug effects Amino Acids - metabolism Associated diseases and complications Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - drug effects Atrial Natriuretic Factor - metabolism Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cyclic GMP - blood Cyclic GMP - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelins - blood Endothelins - drug effects Endothelins - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Glucose - administration & dosage Glucose - pharmacology Glucose Clamp Technique Heart Rate - drug effects Heart Rate - physiology Humans Infusions, Intravenous Insulin - administration & dosage Insulin - blood Insulin - pharmacology Male Medical sciences Sex Characteristics Endocrinopathy Human Hypertension Hyperinsulinemia Pancreatic hormone Endothelin Prostaglandin Sex Cardiovascular disease Experimental study Non insulin dependent diabetes Insulin Vasodilation Endothelium Vasomotricity Nitric oxide Endothelium derived relaxing factor
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