Interleukin-27 and interleukin-37 are elevated in sickle cell anemia patients and inhibit in vitro secretion of interleukin-8 in neutrophils and monocytes

•This study represents the first report on the role of IL-27 and IL-37 in sickle cell anemia.•The levels of IL-27 and IL-37 are elevated in patients that are not on hydroxyurea therapy.•IL-27 and IL-37 significantly inhibit the in vitro production of IL-8 of neutrophils and monocytes.•Both IL-27 and...

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Bibliographic Details
Published in:	Cytokine (Philadelphia, Pa.) Vol. 107; pp. 85 - 92
Main Authors:	Alagbe, A.E., Justo Junior, A.S., Ruas, L.P., Tonassé, W.V., Santana, R.M., Batista, T.H.C., Domingos, I.F., Araujo, A.S., Bezerra, M.A.C., Santos, M.N.N., Blotta, M.H.S.L.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2018
Subjects:	Adult Anemia, Sickle Cell - metabolism Cells, Cultured Cross-Sectional Studies Cytokines - metabolism Female Heme Humans Hydroxyurea IL-27 IL-37 Inflammation Inflammation - metabolism Interleukin-1 - metabolism Interleukin-8 - metabolism Interleukins - metabolism Male Monocytes - metabolism Neutrophils - metabolism Sickle cell anemia Young Adult IL-27 IL-37 Hydroxyurea Inflammation Sickle cell anemia Heme
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