Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in C9orf72 among first-degree relatives of patients with ALS carrying the repeat expansion

We aimed to estimate the age-related risk of ALS in first-degree relatives of patients with ALS carrying the repeat expansion. We included all patients with ALS carrying a repeat expansion in The Netherlands. Using structured questionnaires, we determined the number of first-degree relatives, their...

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Bibliographic Details

Published in:	Amyotrophic lateral sclerosis and frontotemporal degeneration Vol. 25; no. 1-2; pp. 188 - 196
Main Authors:	Van Wijk, Iris F, Van Eijk, Ruben P A, Van Boxmeer, Loes, Westeneng, Henk-Jan, Van Es, Michael A, Van Rheenen, Wouter, Van Den Berg, Leonard H, Eijkemans, Marinus J C, Veldink, Jan H
Format:	Journal Article
Language:	English
Published:	England 01-02-2024
Subjects:	Aged, 80 and over Amyotrophic Lateral Sclerosis - epidemiology Amyotrophic Lateral Sclerosis - genetics C9orf72 Protein - genetics DNA Repeat Expansion - genetics Frontotemporal Dementia - genetics Humans Proteins - genetics c9orf72 penetrance
Online Access:	Get full text
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