DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls

Erectile Dysfunction (ED) is one of the main complaints of aging male. A reduced production of Nitric Oxide (NO) may be involved in ED pathogenesis. NO is synthesized from l-Arginine, and asymmetrical dimethylarginine inhibits all NO synthases. DDAH1 and DDAH2 are genes that encode enzymes responsib...

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Bibliographic Details
Published in:	Nitric oxide Vol. 92; pp. 11 - 17
Main Authors:	Brites-Anselmi, Guilhermo, Azevedo, Ana Maria Milanez, Miyazaki, Anderson Heiji Lima, Pinheiro, Lucas Cezar, Coeli-Lacchini, Fernanda Borchers, de Andrade, Murilo Ferreira, Molina, Carlos Augusto Fernandes, Tucci, Silvio, Hirsch, Emilio, Tanus-Santos, Jose Eduardo, Lacchini, Riccardo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2019
Subjects:	Adult Aged Aged, 80 and over Amidohydrolases - antagonists & inhibitors Amidohydrolases - genetics Amidohydrolases - metabolism Arginine - analogs & derivatives Arginine - blood Arginine - pharmacology Asymmetrical dimethylarginine DDAH1 DDAH2 Erectile dysfunction Erectile Dysfunction - blood Erectile Dysfunction - enzymology Female Genetic polymorphisms Humans Male Middle Aged Nitric oxide Nitric Oxide - biosynthesis Polymorphism, Genetic - genetics Erectile dysfunction Asymmetrical dimethylarginine DDAH1 DDAH2 Nitric oxide Genetic polymorphisms
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