Immunolocalization of Leptin and its Receptor (ObR-b) in Equine Placenta at Term and Plasma Level Measurement in the Late Gestation
Placental tissues from humans, rodents, and farm animal contain leptin and its receptor. Expression of leptin has already been described in horses, although there is no description about immunolocalization of leptin and its receptor. The aim of the present study was to investigate the presence and d...
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| Published in: | Journal of equine veterinary science Vol. 78; pp. 1 - 5 |
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| Abstract | Placental tissues from humans, rodents, and farm animal contain leptin and its receptor. Expression of leptin has already been described in horses, although there is no description about immunolocalization of leptin and its receptor. The aim of the present study was to investigate the presence and distribution of leptin and ObR-b in the equine placenta at term by immunofluorescence staining, and the changes on plasma leptin concentrations during late gestation. The present study involved eight Criollo-type mares carrying healthy pregnancies. Blood samples were collected during the third trimester of gestation, at foaling, and at 24 hours after foaling. Leptin concentrations were analyzed via radioimmunoassay. Plasma leptin concentrations did not change from the 8th to the 10th month of gestation and displayed a discrete decrease 24 hours after parturition (P = .07). The expression of leptin and ObR-b was observed in the cytoplasm of pseudostratified epithelial cells in the areolar region and in the epithelium of microcotyledons. Also, leptin receptor was allocated in the apical surface of the cells. The presence of leptin and its receptor (ObR-b) in the placenta of mares at term supports an endocrine and autocrine/paracrine action of leptin within this organ.
•Leptin and its receptor are present in equine placenta at term.•Leptin and its receptor promote an intrinsic endocrine regulation in placenta.•Plasma leptin level remained constant from eighth month of gestation until foaling. |
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| AbstractList | Placental tissues from humans, rodents, and farm animal contain leptin and its receptor. Expression of leptin has already been described in horses, although there is no description about immunolocalization of leptin and its receptor. The aim of the present study was to investigate the presence and distribution of leptin and ObR-b in the equine placenta at term by immunofluorescence staining, and the changes on plasma leptin concentrations during late gestation. The present study involved eight Criollo-type mares carrying healthy pregnancies. Blood samples were collected during the third trimester of gestation, at foaling, and at 24 hours after foaling. Leptin concentrations were analyzed via radioimmunoassay. Plasma leptin concentrations did not change from the 8th to the 10th month of gestation and displayed a discrete decrease 24 hours after parturition (P = .07). The expression of leptin and ObR-b was observed in the cytoplasm of pseudostratified epithelial cells in the areolar region and in the epithelium of microcotyledons. Also, leptin receptor was allocated in the apical surface of the cells. The presence of leptin and its receptor (ObR-b) in the placenta of mares at term supports an endocrine and autocrine/paracrine action of leptin within this organ.
•Leptin and its receptor are present in equine placenta at term.•Leptin and its receptor promote an intrinsic endocrine regulation in placenta.•Plasma leptin level remained constant from eighth month of gestation until foaling. Placental tissues from humans, rodents, and farm animal contain leptin and its receptor. Expression of leptin has already been described in horses, although there is no description about immunolocalization of leptin and its receptor. The aim of the present study was to investigate the presence and distribution of leptin and ObR-b in the equine placenta at term by immunofluorescence staining, and the changes on plasma leptin concentrations during late gestation. The present study involved eight Criollo-type mares carrying healthy pregnancies. Blood samples were collected during the third trimester of gestation, at foaling, and at 24 hours after foaling. Leptin concentrations were analyzed via radioimmunoassay. Plasma leptin concentrations did not change from the 8th to the 10th month of gestation and displayed a discrete decrease 24 hours after parturition (P = .07). The expression of leptin and ObR-b was observed in the cytoplasm of pseudostratified epithelial cells in the areolar region and in the epithelium of microcotyledons. Also, leptin receptor was allocated in the apical surface of the cells. The presence of leptin and its receptor (ObR-b) in the placenta of mares at term supports an endocrine and autocrine/paracrine action of leptin within this organ. |
| Author | Moreira, Fabiana Curcio, Bruna da Rosa Corcini, Carine Dahl Wendt, Camila Gervini Schmit, Rubia Alves Pazinato, Fernanda Maria Nogueira, Carlos Eduardo Wayne Varela Junior, Antonio Sergio |
| Author_xml | – sequence: 1 givenname: Fernanda Maria surname: Pazinato fullname: Pazinato, Fernanda Maria organization: Departamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Capão do Leão, Pelotas, Rio Grande do Sul, Brazil – sequence: 2 givenname: Bruna da Rosa orcidid: 0000-0001-8678-3816 surname: Curcio fullname: Curcio, Bruna da Rosa email: curciobruna@hotmail.com organization: Departamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Capão do Leão, Pelotas, Rio Grande do Sul, Brazil – sequence: 3 givenname: Antonio Sergio surname: Varela Junior fullname: Varela Junior, Antonio Sergio organization: Departamento de Reprodução Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Campus Universitário, Pelotas, Rio Grande do Sul, Brazil – sequence: 4 givenname: Carine Dahl orcidid: 0000-0001-5683-7801 surname: Corcini fullname: Corcini, Carine Dahl organization: Departamento de Reprodução Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Campus Universitário, Pelotas, Rio Grande do Sul, Brazil – sequence: 5 givenname: Camila Gervini surname: Wendt fullname: Wendt, Camila Gervini organization: Departamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Capão do Leão, Pelotas, Rio Grande do Sul, Brazil – sequence: 6 givenname: Fabiana surname: Moreira fullname: Moreira, Fabiana organization: Departamento de Reprodução Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Campus Universitário, Pelotas, Rio Grande do Sul, Brazil – sequence: 7 givenname: Rubia Alves surname: Schmit fullname: Schmit, Rubia Alves organization: Departamento de Reprodução Animal e Radiologia Veterinária, Universidade Estadual Paulista “Júlio de Mesquita Filho” – Campus Botucatu, Botucatu, São Paulo, Brazil – sequence: 8 givenname: Carlos Eduardo Wayne surname: Nogueira fullname: Nogueira, Carlos Eduardo Wayne organization: Departamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Capão do Leão, Pelotas, Rio Grande do Sul, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31203970$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_7717_peerj_13982 crossref_primary_10_1016_j_domaniend_2024_106857 crossref_primary_10_1016_j_domaniend_2024_106852 |
| Cites_doi | 10.1006/bbrc.2002.6355 10.1186/s12958-015-0003-6 10.2527/jas.2006-771 10.1073/pnas.94.20.11073 10.1016/S0739-7240(03)00044-4 10.1530/ror.0.0050018 10.1677/joe.0.1780217 10.1186/1477-7827-7-113 10.1210/endo.138.10.5573 10.1590/1678-4162-7705 10.1016/j.acthis.2011.12.008 10.1095/biolreprod63.1.335 10.1016/j.domaniend.2005.02.006 10.1111/j.1439-0396.2011.01263.x 10.1095/biolreprod.105.045120 10.1111/j.1439-0531.2007.00963.x 10.1016/j.rvsc.2012.06.001 10.1038/372425a0 10.1111/j.2042-3306.1983.tb01826.x 10.1016/j.acthis.2013.05.008 10.1016/j.anireprosci.2009.03.002 10.1016/S0002-9378(98)70118-8 10.1053/plac.1999.0431 10.1038/29795 |
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| Keywords | Placental metabolism Autocrine action Immunofluorescence Mares |
| Language | English |
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| References | Dall'Aglio, Polisca, Boiti, Ceccarelli (bib5) 2012; 114 Dall'Aglio, Mercati, Pascucci, Ceccarelli (bib9) 2013; 115 Henson, Castracane (bib26) 2006; 74 Henneke, Potter, Kreider, Yeates (bib16) 1983; 15 Kędzierski, Kapica, Kolstrung, Pluta (bib25) 2008; 64 Hoggard, Hunter, Duncan, Williams, Trayhurn, Mercer (bib22) 1997; 94 Ferreira-Dias, Claudino, Carvalho, Agricola, Alpoim-Moreira, Robalo Silva (bib12) 2005; 29 Guibourdenche, Tarrade, Laurendeau, Rochette-Egly, Chambon, Vidaud (bib3) 2000; 85 Dall'Aglio, Maranesi, Pascucci, Mercati, Ceccarelli (bib8) 2012; 93 Gentry, Thompson, Gentry, Davis, Godke, Cartmill (bib13) 2002; 80 Heidler, Parvizi, Sauerwein, Bruckmaier, Heintges, Aurich (bib27) 2003; 25 Kimura, Irahara, Yasui, Saito, Tezuka, Yamano (bib2) 2002; 290 Cebulj-Kadunc, Kosec, Cestnik (bib10) 2009; 44 Bodner, Ebenbichler, Wolf, Muller-Holzner, Stanzl, Gander (bib21) 1999; 20 El-Maaty, Gabr (bib11) 2010; 117 Amato, Martin, Dumon, Jaillardon, Nguyen, Siliart (bib24) 2012; 96 Chavatte-Palmer, Madia, Duchamp, Wimel, Camous, Guillaume (bib15) 2010; 1 Ashworth, Hoggard, Thomas, Mercer, Wallace, Lea (bib6) 2000; 5 Schlafer (bib17) 2004; 50 Fitzgerald, McManus (bib14) 2000; 63 Balogh, Staub, Gram, Boos, Kowalewski, Reichler (bib4) 2015; 13 Consiglio, Dell'Aquila, Fiandanese, Ambruosi, Cho, Bosi (bib18) 2009; 7 Sivan, Whittaker, Sinha, Homko, Lin, Reece (bib20) 1998; 179 Berg, McNamara, Keisler (bib28) 2007; 85 Senaris, Garcia-Caballero, Casabiell, Gallego, Castro, Considine (bib19) 1997; 138 Marchiori, Kasinger, Silva, Souza, Amaral, Nogueira (bib23) 2015; 67 Lord, Matarese, Howard, Baker, Bloom, Lechler (bib29) 1998; 394 Bohlender, Rauh, Zenk, Groschl (bib7) 2003; 178 Zhang, Proenca, Maffei, Barone, Leopold, Friedman (bib1) 1994; 372 Zhang (10.1016/j.jevs.2019.03.008_bib1) 1994; 372 Cebulj-Kadunc (10.1016/j.jevs.2019.03.008_bib10) 2009; 44 Amato (10.1016/j.jevs.2019.03.008_bib24) 2012; 96 Lord (10.1016/j.jevs.2019.03.008_bib29) 1998; 394 Ferreira-Dias (10.1016/j.jevs.2019.03.008_bib12) 2005; 29 Bohlender (10.1016/j.jevs.2019.03.008_bib7) 2003; 178 El-Maaty (10.1016/j.jevs.2019.03.008_bib11) 2010; 117 Sivan (10.1016/j.jevs.2019.03.008_bib20) 1998; 179 Consiglio (10.1016/j.jevs.2019.03.008_bib18) 2009; 7 Ashworth (10.1016/j.jevs.2019.03.008_bib6) 2000; 5 Senaris (10.1016/j.jevs.2019.03.008_bib19) 1997; 138 Dall'Aglio (10.1016/j.jevs.2019.03.008_bib8) 2012; 93 Dall'Aglio (10.1016/j.jevs.2019.03.008_bib9) 2013; 115 Kimura (10.1016/j.jevs.2019.03.008_bib2) 2002; 290 Balogh (10.1016/j.jevs.2019.03.008_bib4) 2015; 13 Henneke (10.1016/j.jevs.2019.03.008_bib16) 1983; 15 Henson (10.1016/j.jevs.2019.03.008_bib26) 2006; 74 Hoggard (10.1016/j.jevs.2019.03.008_bib22) 1997; 94 Kędzierski (10.1016/j.jevs.2019.03.008_bib25) 2008; 64 Bodner (10.1016/j.jevs.2019.03.008_bib21) 1999; 20 Gentry (10.1016/j.jevs.2019.03.008_bib13) 2002; 80 Chavatte-Palmer (10.1016/j.jevs.2019.03.008_bib15) 2010; 1 Fitzgerald (10.1016/j.jevs.2019.03.008_bib14) 2000; 63 Schlafer (10.1016/j.jevs.2019.03.008_bib17) 2004; 50 Heidler (10.1016/j.jevs.2019.03.008_bib27) 2003; 25 Dall'Aglio (10.1016/j.jevs.2019.03.008_bib5) 2012; 114 Guibourdenche (10.1016/j.jevs.2019.03.008_bib3) 2000; 85 Marchiori (10.1016/j.jevs.2019.03.008_bib23) 2015; 67 Berg (10.1016/j.jevs.2019.03.008_bib28) 2007; 85 |
| References_xml | – volume: 117 start-page: 95 year: 2010 end-page: 98 ident: bib11 article-title: Relation between leptin and estradiol levels in Egyptian lactating Arab mares during foaling heat publication-title: Anim Reprod Sci contributor: fullname: Gabr – volume: 394 start-page: 897 year: 1998 end-page: 901 ident: bib29 article-title: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression publication-title: Nature contributor: fullname: Lechler – volume: 5 start-page: 18 year: 2000 end-page: 24 ident: bib6 article-title: Placental leptin publication-title: Rev Reprod contributor: fullname: Lea – volume: 179 start-page: 1128 year: 1998 end-page: 1132 ident: bib20 article-title: Leptin in human pregnancy: the relationship with gestational hormones publication-title: Am J Obstet Gynecol contributor: fullname: Reece – volume: 94 start-page: 11073 year: 1997 end-page: 11078 ident: bib22 article-title: Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta publication-title: Proc Natl Acad Sci U S A contributor: fullname: Mercer – volume: 85 start-page: 2550 year: 2000 end-page: 2555 ident: bib3 article-title: Retinoids stimulate leptin synthesis and secretion in human syncytiotrophoblast publication-title: J Clin Endocrinol Metab contributor: fullname: Vidaud – volume: 44 start-page: 1 year: 2009 end-page: 5 ident: bib10 article-title: Serum leptin concentrations in Lipizzan fillies publication-title: Reprod Domest Anim contributor: fullname: Cestnik – volume: 7 start-page: 113 year: 2009 ident: bib18 article-title: Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horse publication-title: Reprod Biol Endocrinol contributor: fullname: Bosi – volume: 74 start-page: 218 year: 2006 end-page: 229 ident: bib26 article-title: Leptin in pregnancy: an update publication-title: Biol Reprod contributor: fullname: Castracane – volume: 178 start-page: 217 year: 2003 end-page: 223 ident: bib7 article-title: Differential distribution and expression of leptin and the functional leptin receptor in major salivary glands of humans publication-title: J Endocrinol contributor: fullname: Groschl – volume: 114 start-page: 719 year: 2012 end-page: 722 ident: bib5 article-title: Immunolocalization of leptin and its receptor in the placenta of cats publication-title: Acta Histochem contributor: fullname: Ceccarelli – volume: 93 start-page: 1116 year: 2012 end-page: 1118 ident: bib8 article-title: Immunohistochemical distribution of leptin receptor in the major salivary glands of horses publication-title: Res Vet Sci contributor: fullname: Ceccarelli – volume: 80 start-page: 2695 year: 2002 end-page: 2703 ident: bib13 article-title: The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period publication-title: J Anim Sci contributor: fullname: Cartmill – volume: 29 start-page: 203 year: 2005 end-page: 213 ident: bib12 article-title: Seasonal reproduction in the mare: possible role of plasma leptin, body weight and immune status publication-title: Domest Anim Endocrinol contributor: fullname: Robalo Silva – volume: 290 start-page: 1349 year: 2002 end-page: 1353 ident: bib2 article-title: The obesity in bilateral ovariectomized rats is related to a decrease in the expression of leptin receptors in the brain publication-title: Biochem Biophys Res Commun contributor: fullname: Yamano – volume: 372 start-page: 425 year: 1994 end-page: 432 ident: bib1 article-title: Positional cloning of the mouse obese gene and its human homologue publication-title: Nature contributor: fullname: Friedman – volume: 67 start-page: 707 year: 2015 end-page: 715 ident: bib23 article-title: Medidas comparativas do padrão morfométrico e perfil energético de éguas Crioulas no terço final da gestação, com diferentes escores corporais publication-title: Arq Bras Med Vet Zootec contributor: fullname: Nogueira – volume: 96 start-page: 850 year: 2012 end-page: 859 ident: bib24 article-title: Variations in plasma leptin in show horses during a work season publication-title: J Anim Physiol Anim Nutr (Berl) contributor: fullname: Siliart – volume: 20 start-page: 677 year: 1999 end-page: 682 ident: bib21 article-title: Leptin receptor in human term placenta: in situ hybridization and immunohistochemical localization publication-title: Placenta contributor: fullname: Gander – volume: 13 start-page: 13 year: 2015 ident: bib4 article-title: Leptin in the canine uterus and placenta: possible implications in pregnancy publication-title: Reprod Biol Endocrinol contributor: fullname: Reichler – volume: 85 start-page: 1660 year: 2007 end-page: 1668 ident: bib28 article-title: Endocrine profiles of periparturient mares and their foals publication-title: J Anim Sci contributor: fullname: Keisler – volume: 115 start-page: 757 year: 2013 end-page: 760 ident: bib9 article-title: Immunolocalization of leptin and its receptor in the pancreas of the horse publication-title: Acta Histochem contributor: fullname: Ceccarelli – volume: 64 start-page: 427 year: 2008 end-page: 430 ident: bib25 article-title: Concentration of plasma leptin, ghrelin and parameters of lipid metabolism in purebred Arabian and pony mares during the periparturient period (Abstract in English) publication-title: Med Weter contributor: fullname: Pluta – volume: 1 start-page: 1 year: 2010 ident: bib15 publication-title: Placental Expression and Neonatal Plasma Concentrations of Leptin in Horses and Ponies. Book of Abstracts of the 61st Annual Meeting of the European Association for Animal Production. contributor: fullname: Guillaume – volume: 25 start-page: 47 year: 2003 end-page: 59 ident: bib27 article-title: Effects of lactation on metabolic and reproductive hormones in Lipizzaner mares publication-title: Domest Anim Endocrinol contributor: fullname: Aurich – volume: 15 start-page: 371 year: 1983 end-page: 372 ident: bib16 article-title: Relationship between condition score, physical measurements and body fat percentage in mares publication-title: Equine Vet J contributor: fullname: Yeates – volume: 138 start-page: 4501 year: 1997 end-page: 4504 ident: bib19 article-title: Synthesis of leptin in human placenta publication-title: Endocrinology contributor: fullname: Considine – volume: 50 start-page: 18 year: 2004 ident: bib17 publication-title: Postmortem examination of the equine placenta, fetus, and neonate: methods and interpretation of findings. Proceedings AAEP. contributor: fullname: Schlafer – volume: 63 start-page: 335 year: 2000 end-page: 340 ident: bib14 article-title: Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare publication-title: Biol Reprod contributor: fullname: McManus – volume: 290 start-page: 1349 year: 2002 ident: 10.1016/j.jevs.2019.03.008_bib2 article-title: The obesity in bilateral ovariectomized rats is related to a decrease in the expression of leptin receptors in the brain publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2002.6355 contributor: fullname: Kimura – volume: 64 start-page: 427 year: 2008 ident: 10.1016/j.jevs.2019.03.008_bib25 article-title: Concentration of plasma leptin, ghrelin and parameters of lipid metabolism in purebred Arabian and pony mares during the periparturient period (Abstract in English) publication-title: Med Weter contributor: fullname: Kędzierski – volume: 13 start-page: 13 year: 2015 ident: 10.1016/j.jevs.2019.03.008_bib4 article-title: Leptin in the canine uterus and placenta: possible implications in pregnancy publication-title: Reprod Biol Endocrinol doi: 10.1186/s12958-015-0003-6 contributor: fullname: Balogh – volume: 85 start-page: 1660 year: 2007 ident: 10.1016/j.jevs.2019.03.008_bib28 article-title: Endocrine profiles of periparturient mares and their foals publication-title: J Anim Sci doi: 10.2527/jas.2006-771 contributor: fullname: Berg – volume: 1 start-page: 1 year: 2010 ident: 10.1016/j.jevs.2019.03.008_bib15 contributor: fullname: Chavatte-Palmer – volume: 94 start-page: 11073 year: 1997 ident: 10.1016/j.jevs.2019.03.008_bib22 article-title: Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.20.11073 contributor: fullname: Hoggard – volume: 25 start-page: 47 year: 2003 ident: 10.1016/j.jevs.2019.03.008_bib27 article-title: Effects of lactation on metabolic and reproductive hormones in Lipizzaner mares publication-title: Domest Anim Endocrinol doi: 10.1016/S0739-7240(03)00044-4 contributor: fullname: Heidler – volume: 85 start-page: 2550 year: 2000 ident: 10.1016/j.jevs.2019.03.008_bib3 article-title: Retinoids stimulate leptin synthesis and secretion in human syncytiotrophoblast publication-title: J Clin Endocrinol Metab contributor: fullname: Guibourdenche – volume: 5 start-page: 18 year: 2000 ident: 10.1016/j.jevs.2019.03.008_bib6 article-title: Placental leptin publication-title: Rev Reprod doi: 10.1530/ror.0.0050018 contributor: fullname: Ashworth – volume: 178 start-page: 217 year: 2003 ident: 10.1016/j.jevs.2019.03.008_bib7 article-title: Differential distribution and expression of leptin and the functional leptin receptor in major salivary glands of humans publication-title: J Endocrinol doi: 10.1677/joe.0.1780217 contributor: fullname: Bohlender – volume: 7 start-page: 113 year: 2009 ident: 10.1016/j.jevs.2019.03.008_bib18 article-title: Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horse publication-title: Reprod Biol Endocrinol doi: 10.1186/1477-7827-7-113 contributor: fullname: Consiglio – volume: 138 start-page: 4501 year: 1997 ident: 10.1016/j.jevs.2019.03.008_bib19 article-title: Synthesis of leptin in human placenta publication-title: Endocrinology doi: 10.1210/endo.138.10.5573 contributor: fullname: Senaris – volume: 67 start-page: 707 year: 2015 ident: 10.1016/j.jevs.2019.03.008_bib23 article-title: Medidas comparativas do padrão morfométrico e perfil energético de éguas Crioulas no terço final da gestação, com diferentes escores corporais publication-title: Arq Bras Med Vet Zootec doi: 10.1590/1678-4162-7705 contributor: fullname: Marchiori – volume: 114 start-page: 719 year: 2012 ident: 10.1016/j.jevs.2019.03.008_bib5 article-title: Immunolocalization of leptin and its receptor in the placenta of cats publication-title: Acta Histochem doi: 10.1016/j.acthis.2011.12.008 contributor: fullname: Dall'Aglio – volume: 63 start-page: 335 year: 2000 ident: 10.1016/j.jevs.2019.03.008_bib14 article-title: Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare publication-title: Biol Reprod doi: 10.1095/biolreprod63.1.335 contributor: fullname: Fitzgerald – volume: 29 start-page: 203 year: 2005 ident: 10.1016/j.jevs.2019.03.008_bib12 article-title: Seasonal reproduction in the mare: possible role of plasma leptin, body weight and immune status publication-title: Domest Anim Endocrinol doi: 10.1016/j.domaniend.2005.02.006 contributor: fullname: Ferreira-Dias – volume: 96 start-page: 850 year: 2012 ident: 10.1016/j.jevs.2019.03.008_bib24 article-title: Variations in plasma leptin in show horses during a work season publication-title: J Anim Physiol Anim Nutr (Berl) doi: 10.1111/j.1439-0396.2011.01263.x contributor: fullname: Amato – volume: 74 start-page: 218 year: 2006 ident: 10.1016/j.jevs.2019.03.008_bib26 article-title: Leptin in pregnancy: an update publication-title: Biol Reprod doi: 10.1095/biolreprod.105.045120 contributor: fullname: Henson – volume: 44 start-page: 1 year: 2009 ident: 10.1016/j.jevs.2019.03.008_bib10 article-title: Serum leptin concentrations in Lipizzan fillies publication-title: Reprod Domest Anim doi: 10.1111/j.1439-0531.2007.00963.x contributor: fullname: Cebulj-Kadunc – volume: 93 start-page: 1116 year: 2012 ident: 10.1016/j.jevs.2019.03.008_bib8 article-title: Immunohistochemical distribution of leptin receptor in the major salivary glands of horses publication-title: Res Vet Sci doi: 10.1016/j.rvsc.2012.06.001 contributor: fullname: Dall'Aglio – volume: 372 start-page: 425 year: 1994 ident: 10.1016/j.jevs.2019.03.008_bib1 article-title: Positional cloning of the mouse obese gene and its human homologue publication-title: Nature doi: 10.1038/372425a0 contributor: fullname: Zhang – volume: 15 start-page: 371 year: 1983 ident: 10.1016/j.jevs.2019.03.008_bib16 article-title: Relationship between condition score, physical measurements and body fat percentage in mares publication-title: Equine Vet J doi: 10.1111/j.2042-3306.1983.tb01826.x contributor: fullname: Henneke – volume: 115 start-page: 757 year: 2013 ident: 10.1016/j.jevs.2019.03.008_bib9 article-title: Immunolocalization of leptin and its receptor in the pancreas of the horse publication-title: Acta Histochem doi: 10.1016/j.acthis.2013.05.008 contributor: fullname: Dall'Aglio – volume: 117 start-page: 95 year: 2010 ident: 10.1016/j.jevs.2019.03.008_bib11 article-title: Relation between leptin and estradiol levels in Egyptian lactating Arab mares during foaling heat publication-title: Anim Reprod Sci doi: 10.1016/j.anireprosci.2009.03.002 contributor: fullname: El-Maaty – volume: 179 start-page: 1128 year: 1998 ident: 10.1016/j.jevs.2019.03.008_bib20 article-title: Leptin in human pregnancy: the relationship with gestational hormones publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(98)70118-8 contributor: fullname: Sivan – volume: 20 start-page: 677 year: 1999 ident: 10.1016/j.jevs.2019.03.008_bib21 article-title: Leptin receptor in human term placenta: in situ hybridization and immunohistochemical localization publication-title: Placenta doi: 10.1053/plac.1999.0431 contributor: fullname: Bodner – volume: 80 start-page: 2695 year: 2002 ident: 10.1016/j.jevs.2019.03.008_bib13 article-title: The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period publication-title: J Anim Sci contributor: fullname: Gentry – volume: 394 start-page: 897 year: 1998 ident: 10.1016/j.jevs.2019.03.008_bib29 article-title: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression publication-title: Nature doi: 10.1038/29795 contributor: fullname: Lord – volume: 50 start-page: 18 year: 2004 ident: 10.1016/j.jevs.2019.03.008_bib17 contributor: fullname: Schlafer |
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| Title | Immunolocalization of Leptin and its Receptor (ObR-b) in Equine Placenta at Term and Plasma Level Measurement in the Late Gestation |
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