Evaluation of choroidal thickness and choroidal vascularity index during pregnancy
To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method. Prospective study. Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregna...
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Published in: | Canadian journal of ophthalmology Vol. 56; no. 4; pp. 237 - 243 |
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Abstract | To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method.
Prospective study.
Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3).
The choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software.
The mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively).
There was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters.
Évaluer les caractéristiques de la structure de la choroïde pendant le premier et le troisième trimestre de la grossesse à l'aide de la tomographie par cohérence optique à l'imagerie à profondeur améliorée et d'une stratégie de binarisation.
Étude prospective.
Ont été examinés 25 yeux de 25 femmes au premier trimestre de la grossesse (groupe 1) et 25 yeux de 25 femmes au troisième trimestre de la grossesse (groupe 2). Le groupe témoin (groupe 3) était formé de 25 participantes appariées pour l’âge et en bonne santé (groupe 3).
On a mesuré l’épaisseur de la choroïde (EC) à 3 endroits : dans la sous-fovéa, à 1500 μm en nasal de la fovéa et à 1500 μm en temporal de la fovéa. On a eu recours au logiciel ImageJ pour mesurer la surface totale de la choroïde, la zone luminale, la zone stromale, le rapport stroma/lumen et l'indice de vascularisation choroïdienne (CVI, pour choroidal vascularity index).
L'EC sous-fovéale et nasale moyenne était significativement plus élevée dans le groupe 1, comparativement au groupe témoin (p = 0,005 et p = 0,004, respectivement). De même, l'EC temporale moyenne était significativement plus élevée dans le groupe 1, comparativement aux groupes 2 et 3 (groupe 1 vs groupe 2, p = 0,043; groupe 1 vs groupe 3, p = 0,011). La surface totale de la choroïde, la zone stromale et la zone luminale moyenne étaient significativement plus élevées dans les groupes 1 et 2, comparativement au groupe témoin (p < 0,001; p < 0,001; p < 0,001 et p < 0,001; p = 0,002; p = 0,002, respectivement). On n'a noté aucune différence statistiquement significative entre les groupes quant au rapport stroma/lumen ni au CVI moyen (p = 0,148 et p = 0,312, respectivement).
On a enregistré une hausse significative de l'EC sous-fovéale, temporale et nasale pendant le premier trimestre de la grossesse. La surface totale de la choroïde, la zone stromale et la zone luminale moyenne, quant à elles, étaient significativement plus élevées pendant le premier et le troisième trimestre de la grossesse. |
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AbstractList | OBJECTIVETo assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method. DESIGNProspective study. PARTICIPANTSTwenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3). METHODSThe choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software. RESULTSThe mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively). CONCLUSIONSThere was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters. To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method. Prospective study. Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3). The choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software. The mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively). There was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters. To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method. Prospective study. Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3). The choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software. The mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively). There was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters. Évaluer les caractéristiques de la structure de la choroïde pendant le premier et le troisième trimestre de la grossesse à l'aide de la tomographie par cohérence optique à l'imagerie à profondeur améliorée et d'une stratégie de binarisation. Étude prospective. Ont été examinés 25 yeux de 25 femmes au premier trimestre de la grossesse (groupe 1) et 25 yeux de 25 femmes au troisième trimestre de la grossesse (groupe 2). Le groupe témoin (groupe 3) était formé de 25 participantes appariées pour l’âge et en bonne santé (groupe 3). On a mesuré l’épaisseur de la choroïde (EC) à 3 endroits : dans la sous-fovéa, à 1500 μm en nasal de la fovéa et à 1500 μm en temporal de la fovéa. On a eu recours au logiciel ImageJ pour mesurer la surface totale de la choroïde, la zone luminale, la zone stromale, le rapport stroma/lumen et l'indice de vascularisation choroïdienne (CVI, pour choroidal vascularity index). L'EC sous-fovéale et nasale moyenne était significativement plus élevée dans le groupe 1, comparativement au groupe témoin (p = 0,005 et p = 0,004, respectivement). De même, l'EC temporale moyenne était significativement plus élevée dans le groupe 1, comparativement aux groupes 2 et 3 (groupe 1 vs groupe 2, p = 0,043; groupe 1 vs groupe 3, p = 0,011). La surface totale de la choroïde, la zone stromale et la zone luminale moyenne étaient significativement plus élevées dans les groupes 1 et 2, comparativement au groupe témoin (p < 0,001; p < 0,001; p < 0,001 et p < 0,001; p = 0,002; p = 0,002, respectivement). On n'a noté aucune différence statistiquement significative entre les groupes quant au rapport stroma/lumen ni au CVI moyen (p = 0,148 et p = 0,312, respectivement). On a enregistré une hausse significative de l'EC sous-fovéale, temporale et nasale pendant le premier trimestre de la grossesse. La surface totale de la choroïde, la zone stromale et la zone luminale moyenne, quant à elles, étaient significativement plus élevées pendant le premier et le troisième trimestre de la grossesse. |
Author | Örnek, Kemal Kocamış, Özkan Temel, Emine Arıöz, Okan Aşıkgarip, Nazife |
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