Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis
Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the preven...
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| Published in: | World neurosurgery Vol. 122; pp. e989 - e994 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-02-2019
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| Abstract | Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis.
Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). The negative control group received no surgery, and the positive control group underwent laminectomy only. Experimental groups were classified according to the study agents applied onto the dura mater after laminectomy at the L3 level: 2.5% boric acid solution and 5% boric acid solution. The extent of epidural fibrosis was assessed 4 weeks later macroscopically and histopathologically.
Boric acid reduced epidural fibrosis in rats after laminectomy. The effect of 5% boric acid solution was more pronounced (P < 0.05) compared with the 2.5% solution.
The antifibrotic effect of boric acid solution for the prevention of epidural fibrosis suggests that boric acid should be further evaluated in future studies for the prevention of epidural fibrosis. |
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| AbstractList | BACKGROUNDEpidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis.METHODSRats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). The negative control group received no surgery, and the positive control group underwent laminectomy only. Experimental groups were classified according to the study agents applied onto the dura mater after laminectomy at the L3 level: 2.5% boric acid solution and 5% boric acid solution. The extent of epidural fibrosis was assessed 4 weeks later macroscopically and histopathologically.RESULTSBoric acid reduced epidural fibrosis in rats after laminectomy. The effect of 5% boric acid solution was more pronounced (P < 0.05) compared with the 2.5% solution.CONCLUSIONSThe antifibrotic effect of boric acid solution for the prevention of epidural fibrosis suggests that boric acid should be further evaluated in future studies for the prevention of epidural fibrosis. Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis. Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). The negative control group received no surgery, and the positive control group underwent laminectomy only. Experimental groups were classified according to the study agents applied onto the dura mater after laminectomy at the L3 level: 2.5% boric acid solution and 5% boric acid solution. The extent of epidural fibrosis was assessed 4 weeks later macroscopically and histopathologically. Boric acid reduced epidural fibrosis in rats after laminectomy. The effect of 5% boric acid solution was more pronounced (P < 0.05) compared with the 2.5% solution. The antifibrotic effect of boric acid solution for the prevention of epidural fibrosis suggests that boric acid should be further evaluated in future studies for the prevention of epidural fibrosis. |
| Author | Borekci, Ali Öztürk, Özden Çağlar Eğilmez, Reyhan Kertmen, Hayri Kuru Bektaşoğlu, Pınar Yüce, Mehmet Fatih Bozkurt, Hüseyin Gürer, Bora |
| Author_xml | – sequence: 1 givenname: Hüseyin surname: Bozkurt fullname: Bozkurt, Hüseyin organization: Department of Neurosurgery, Sivas Cumhuriyet University School of Medicine, Sivas, Turkey – sequence: 2 givenname: Pınar orcidid: 0000-0001-9889-9955 surname: Kuru Bektaşoğlu fullname: Kuru Bektaşoğlu, Pınar email: pnr.kuru@gmail.com organization: Department of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey – sequence: 3 givenname: Ali surname: Borekci fullname: Borekci, Ali organization: Department of Neurosurgery, Sancaktepe Şehit Prof.Dr. İlhan Varank Education and Research Hospital, Turkish Ministry of Health, Istanbul, Turkey – sequence: 4 givenname: Özden Çağlar surname: Öztürk fullname: Öztürk, Özden Çağlar organization: Department of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey – sequence: 5 givenname: Hayri surname: Kertmen fullname: Kertmen, Hayri organization: Department of Neurosurgery, Dışkapı Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Ankara, Turkey – sequence: 6 givenname: Reyhan surname: Eğilmez fullname: Eğilmez, Reyhan organization: Department of Pathology, Sivas Cumhuriyet University School of Medicine, Sivas, Turkey – sequence: 7 givenname: Mehmet Fatih surname: Yüce fullname: Yüce, Mehmet Fatih organization: Department of Anesthesia, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey – sequence: 8 givenname: Bora surname: Gürer fullname: Gürer, Bora organization: Department of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey |
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| Keywords | Boric acid Laminectomy Epidural fibrosis BA |
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| SubjectTerms | Animals Antifibrinolytic Agents - pharmacology Antifibrinolytic Agents - therapeutic use Boric acid Boric Acids - pharmacology Boric Acids - therapeutic use Cicatrix - drug therapy Cicatrix - etiology Cicatrix - pathology Dose-Response Relationship, Drug Epidural fibrosis Epidural Space - drug effects Epidural Space - pathology Fibrosis Laminectomy Laminectomy - adverse effects Male Postoperative Complications - drug therapy Postoperative Complications - etiology Postoperative Complications - pathology Random Allocation Rats Rats, Wistar Treatment Outcome |
| Title | Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis |
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