HLA antigen-sharing in couples with repeated spontaneous abortions and the birthweight of babies in successful pregnancies

Previously, several groups reported an increase in HLA antigen-sharing in couples suffering from unexplained repeated spontaneous abortions. It was felt necessary to find out if HLA sharing could have any effect on children born after a successful pregnancy. The birthweight figures of children of 76...

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Bibliographic Details
Published in:	American journal of reproductive immunology (1989) Vol. 25; no. 1; p. 25
Main Authors:	Reznikoff-Etievant, M F, Bonneau, J C, Alcalay, D, Cavelier, B, Touré, C, Lobet, R, Netter, A
Format:	Journal Article
Language:	English
Published:	Denmark 01-01-1991
Subjects:	Abortion, Habitual - immunology Birth Weight Female HLA-A Antigens - analysis HLA-B Antigens - analysis HLA-DQ Antigens - analysis HLA-DR Antigens - analysis Humans Infant, Newborn Pregnancy
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Summary:	Previously, several groups reported an increase in HLA antigen-sharing in couples suffering from unexplained repeated spontaneous abortions. It was felt necessary to find out if HLA sharing could have any effect on children born after a successful pregnancy. The birthweight figures of children of 76 couples with repeated spontaneous abortions were analyzed. The results show a significantly lower birthweight in babies born from those couples, presenting a high incidence of HLA antigen-sharing, particularly concerning class II antigens.
ISSN:	1046-7408
DOI:	10.1111/j.1600-0897.1991.tb01059.x