Initial Experience With Biologic Polymer Scaffold (Poly-4-hydroxybuturate) in Complex Abdominal Wall Reconstruction

• Published in: Annals of surgery Vol. 266; no. 1; pp. 185 - 188
• Main Authors: Buell, Joseph F, Sigmon, David, Ducoin, Christopher, Shapiro, Max, Teja, Nikhil, Wynter, Emmett, Hanisee, Mary K, Parker, Geoffrey, Kandil, Emad, Darden, Michael
• Format: Journal Article
• Language: English
• Published: United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-07-2017
• Subjects: Abdominal Wall - surgery; Absorbable Implants - economics; Animals; Cadaver; Cost Savings; Female; Hernia, Abdominal - surgery; Hospital Costs; Humans; Male; Middle Aged; Polyesters; Postoperative Complications; Recurrence; Surgical Mesh - economics; Swine; Tissue Scaffolds - economics
• ISSN: 0003-4932; 1528-1140
• DOI: 10.1097/SLA.0000000000001916

OBJECTIVE:To evaluate the use of the new absorbable polymer scaffold poly-4-hydroxybutyrate (P4HB) in complex abdominal wall reconstruction.
BACKGROUND:Complex abdominal wall reconstruction has witnessed tremendous success in the last decade after the introduction of cadaveric biologic scaffolds. However, the use of cadaveric biologic mesh has been expensive and plagued by complications such as seroma, infection, and recurrent hernia. Despite widespread application of cadaveric biologic mesh, little data exist on the superiority of these materials in the setting of high-risk wounds in patients. P4HB, an absorbable polymer scaffold, may present a new alternative to these cadaveric biologic grafts.
METHODS:A retrospective analysis of our initial experience with the absorbable polymer scaffold P4HB compared with a consecutive contiguous group treated with porcine cadaveric mesh for complex abdominal wall reconstructions. Our analysis was performed using SAS 9.3 and Stata 12.
RESULTS:The P4HB group (n = 31) experienced shorter drain time (10.0 vs 14.3 d; P < 0.002), fewer complications (22.6% vs 40.5%; P < 0.046), and reherniation (6.5% vs 23.8%; P < 0.049) than the porcine cadaveric mesh group (n = 42). Multivariate analysis for infection identifiedporcine cadaveric mesh odds ratio 2.82, length of stay odds ratio 1.11; complicationsdrinker odds ratio 6.52, porcine cadaveric mesh odds ratio 4.03, African American odds ratio 3.08, length of stay odds ratio 1.11; and hernia recurrenceporcine cadaveric mesh odds ratio 5.18, drinker odds ratio 3.62, African American odds ratio 0.24. Cost analysis identified that P4HB had a $7328.91 financial advantage in initial hospitalization and $2241.17 in the 90-day postdischarge global period resulting in $9570.07 per case advantage over porcine cadaveric mesh.
CONCLUSIONS:In our early clinical experience with the absorbable polymer matrix scaffold P4HB, it seemed to provide superior clinical performance and value-based benefit compared with porcine cadaveric biologic mesh.