Identifying Tumor Vascular Permeability Heterogeneity With Magnetic Resonance Imaging Contrast Agents
Aref M, Brechbiel M, Wiener E. Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents. Invest Radiol 2002;37:178–192. RATIONALE AND OBJECTIVES. Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis....
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| Published in: | Investigative radiology Vol. 37; no. 4; pp. 178 - 192 |
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| Language: | English |
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01-04-2002
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| Abstract | Aref M, Brechbiel M, Wiener E. Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents. Invest Radiol 2002;37:178–192.
RATIONALE AND OBJECTIVES. Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp↔t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis.
METHODS. DCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor’s extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp↔t/VT).
RESULTS. For Gd-DTPA ve = 9% to 13% Kp↔t/VT = 0.01 to 0.06 minutes, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp↔t/VT = 0.008 to 0.04 minutes. Significant differences in Kp↔t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range.
CONCLUSIONS. Smaller ROI values or pixels should yield more accurate assessment of neovascularization. |
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| AbstractList | RATIONALE AND OBJECTIVESDynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis.METHODSDCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor's extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp<-->t/VT).RESULTSFor Gd-DTPA ve = 9% to 13% Kp<-->t/VT = 0.01 to 0.06 minutes-1, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp<-->t/VT = 0.008 to 0.04 minutes(-1). Significant differences in Kp<-->t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range.CONCLUSIONSSmaller ROI values or pixels should yield more accurate assessment of neovascularization. Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis. DCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor's extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp<-->t/VT). For Gd-DTPA ve = 9% to 13% Kp<-->t/VT = 0.01 to 0.06 minutes-1, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp<-->t/VT = 0.008 to 0.04 minutes(-1). Significant differences in Kp<-->t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range. Smaller ROI values or pixels should yield more accurate assessment of neovascularization. Aref M, Brechbiel M, Wiener E. Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents. Invest Radiol 2002;37:178–192. RATIONALE AND OBJECTIVES. Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp↔t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis. METHODS. DCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor’s extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp↔t/VT). RESULTS. For Gd-DTPA ve = 9% to 13% Kp↔t/VT = 0.01 to 0.06 minutes, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp↔t/VT = 0.008 to 0.04 minutes. Significant differences in Kp↔t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range. CONCLUSIONS. Smaller ROI values or pixels should yield more accurate assessment of neovascularization. |
| Author | WIENER, ERIK C AREF, MICHAEL BRECHBIEL, MARTIN |
| AuthorAffiliation | From the Department of Nuclear, Plasma, and Radiological Engineering, the †Biomedical Magnetic Resonance Facility, the ‡Beckman Institute, the §Department of Medical Information Science, and the ¶Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, Illinois. ∥ From the National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
| AuthorAffiliation_xml | – name: From the Department of Nuclear, Plasma, and Radiological Engineering, the †Biomedical Magnetic Resonance Facility, the ‡Beckman Institute, the §Department of Medical Information Science, and the ¶Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, Illinois. ∥ From the National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
| Author_xml | – sequence: 1 givenname: MICHAEL surname: AREF fullname: AREF, MICHAEL organization: From the Department of Nuclear, Plasma, and Radiological Engineering, the †Biomedical Magnetic Resonance Facility, the ‡Beckman Institute, the §Department of Medical Information Science, and the ¶Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, Illinois. ∥ From the National Cancer Institute, National Institutes of Health, Bethesda, Maryland – sequence: 2 givenname: MARTIN surname: BRECHBIEL fullname: BRECHBIEL, MARTIN – sequence: 3 givenname: ERIK surname: WIENER middlename: C fullname: WIENER, ERIK C |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11923640$$D View this record in MEDLINE/PubMed |
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| Snippet | Aref M, Brechbiel M, Wiener E. Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents. Invest Radiol... Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface... RATIONALE AND OBJECTIVESDynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response... |
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| SubjectTerms | Animals Capillary Permeability Contrast Media - pharmacokinetics Dendrimers Ethylnitrosourea Gadolinium DTPA - pharmacokinetics Macromolecular Substances Magnetic Resonance Imaging - methods Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - pathology Mathematics Microcirculation Polyamines - pharmacokinetics Rats Rats, Sprague-Dawley |
| Title | Identifying Tumor Vascular Permeability Heterogeneity With Magnetic Resonance Imaging Contrast Agents |
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