Single-dose Universal Hepatitis A Immunization in One-year-old Children in Argentina: High Prevalence of Protective Antibodies up to 9 Years After Vaccination
BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against H...
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| Published in: | The Pediatric infectious disease journal Vol. 35; no. 12; pp. 1339 - 1342 |
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01-12-2016
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| Abstract | BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against HAV after vaccination.
METHODS:Children who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values ≥10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection.
RESULTS:A total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.3–9.2 years). Of these children, 97.4% (95% confidence interval96.3%–98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval163.2–178.2 mUI/mL).
CONCLUSIONS:Single-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention. |
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| AbstractList | Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against HAV after vaccination.
Children who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values ≥10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection.
A total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.3-9.2 years). Of these children, 97.4% (95% confidence interval: 96.3%-98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval: 163.2-178.2 mUI/mL).
Single-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention. BACKGROUNDSingle-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against HAV after vaccination.METHODSChildren who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values ≥10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection.RESULTSA total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.3-9.2 years). Of these children, 97.4% (95% confidence interval: 96.3%-98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval: 163.2-178.2 mUI/mL).CONCLUSIONSSingle-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention. BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against HAV after vaccination. METHODS:Children who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values ≥10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection. RESULTS:A total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.3–9.2 years). Of these children, 97.4% (95% confidence interval96.3%–98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval163.2–178.2 mUI/mL). CONCLUSIONS:Single-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention. |
| Author | Vicentín, Rosalía Urueña, Analía Gentile, Angela González, Jorge E Vizzotti, Carla Uboldi, Andrea Ramonet, Margarita Calli, Rogelio Caglio, Patricia Pagani, María F Cañero-Velasco, María C Rearte, Analía Pérez Carrega, María E |
| AuthorAffiliation | From the Dirección Nacional de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, C.A.B.A., Argentina; †Laboratorio Nacional de Referencia de Hepatitis Virales, INEI-ANLIS “Dr. Carlos Malbrán”, C.A.B.A., Argentina; ‡Dirección de Epidemiología del Ministerio de Salud Pública de la Provincia de Tucumán, Tucumán, Argentina; §Servicio de Gastroenterología. Hospital del Niño Jesús de Tucumán, Tucumán, Argentina; ¶Programa Ampliado de Inmunizaciones, Ministerio de Salud de la Provincia de Santa Fe, Santa Fe, Argentina; ‖Servicio de Gastroenterología, Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina; Hospital Nacional Prof. Dr. Alejandro Posadas, Provincia de Buenos Aires, Argentina; ††Hospital de Niños de San Justo, Provincia de Buenos Aires, Argentina; ‡‡Hospital de Niños Ricardo Gutiérrez, C.A.B.A. Argentina; and §§Comisión Nacional de Hepatología, Sociedad Argentina de pediatría, C.A.B.A., Argentina |
| AuthorAffiliation_xml | – name: From the Dirección Nacional de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, C.A.B.A., Argentina; †Laboratorio Nacional de Referencia de Hepatitis Virales, INEI-ANLIS “Dr. Carlos Malbrán”, C.A.B.A., Argentina; ‡Dirección de Epidemiología del Ministerio de Salud Pública de la Provincia de Tucumán, Tucumán, Argentina; §Servicio de Gastroenterología. Hospital del Niño Jesús de Tucumán, Tucumán, Argentina; ¶Programa Ampliado de Inmunizaciones, Ministerio de Salud de la Provincia de Santa Fe, Santa Fe, Argentina; ‖Servicio de Gastroenterología, Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina; Hospital Nacional Prof. Dr. Alejandro Posadas, Provincia de Buenos Aires, Argentina; ††Hospital de Niños de San Justo, Provincia de Buenos Aires, Argentina; ‡‡Hospital de Niños Ricardo Gutiérrez, C.A.B.A. Argentina; and §§Comisión Nacional de Hepatología, Sociedad Argentina de pediatría, C.A.B.A., Argentina |
| Author_xml | – sequence: 1 givenname: Analía surname: Urueña fullname: Urueña, Analía organization: From the Dirección Nacional de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, C.A.B.A., Argentina; †Laboratorio Nacional de Referencia de Hepatitis Virales, INEI-ANLIS “Dr. Carlos Malbrán”, C.A.B.A., Argentina; ‡Dirección de Epidemiología del Ministerio de Salud Pública de la Provincia de Tucumán, Tucumán, Argentina; §Servicio de Gastroenterología. Hospital del Niño Jesús de Tucumán, Tucumán, Argentina; ¶Programa Ampliado de Inmunizaciones, Ministerio de Salud de la Provincia de Santa Fe, Santa Fe, Argentina; ‖Servicio de Gastroenterología, Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina; Hospital Nacional Prof. Dr. Alejandro Posadas, Provincia de Buenos Aires, Argentina; ††Hospital de Niños de San Justo, Provincia de Buenos Aires, Argentina; ‡‡Hospital de Niños Ricardo Gutiérrez, C.A.B.A. Argentina; and §§Comisión Nacional de Hepatología, Sociedad Argentina de pediatría, C.A.B.A., Argentina – sequence: 2 givenname: Jorge surname: González middlename: E fullname: González, Jorge E – sequence: 3 givenname: Analía surname: Rearte fullname: Rearte, Analía – sequence: 4 givenname: María surname: Pérez Carrega middlename: E fullname: Pérez Carrega, María E – sequence: 5 givenname: Rogelio surname: Calli fullname: Calli, Rogelio – sequence: 6 givenname: María surname: Pagani middlename: F fullname: Pagani, María F – sequence: 7 givenname: Andrea surname: Uboldi fullname: Uboldi, Andrea – sequence: 8 givenname: Rosalía surname: Vicentín fullname: Vicentín, Rosalía – sequence: 9 givenname: Patricia surname: Caglio fullname: Caglio, Patricia – sequence: 10 givenname: María surname: Cañero-Velasco middlename: C fullname: Cañero-Velasco, María C – sequence: 11 givenname: Angela surname: Gentile fullname: Gentile, Angela – sequence: 12 givenname: Margarita surname: Ramonet fullname: Ramonet, Margarita – sequence: 13 givenname: Carla surname: Vizzotti fullname: Vizzotti, Carla |
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| Snippet | BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated... Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high... BACKGROUNDSingle-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated... |
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| SubjectTerms | Argentina Child Female Follow-Up Studies Hepatitis A - prevention & control Hepatitis A Antibodies - blood Hepatitis A Vaccines - administration & dosage Hepatitis A Vaccines - immunology Hepatitis A virus - immunology Humans Infant Male Prevalence |
| Title | Single-dose Universal Hepatitis A Immunization in One-year-old Children in Argentina: High Prevalence of Protective Antibodies up to 9 Years After Vaccination |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27636725 https://search.proquest.com/docview/1839133441 |
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