Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles

Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles

2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was foun...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 52; no. 4; pp. 304 - 307
Main Authors: Ishmetova, R. I., Tolshchina, S. G., Ignatenko, N. K., Kravchenko, M. A., Skornyakov, S. N., Rusinov, G. L., Charushin, V. N.
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2018
Springer
Subjects:
Antitubercular agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
tuberculostatic activity
alkylation
tetrazoles
Mannich reaction
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Summary:2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was found for tetrazoles containing N(2) dimethyl- and diethylaminoethyl fragments.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1811-8