Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma

Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. Epigenetic inactivation of tumor suppressor genes is an important event in head and neck carcinogenesis. Here we analyzed the promoter methylation of 15 genes (RASSF1A, p16, MGMT, DAPK, RAR...

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Bibliographic Details
Published in:	Oncology reports Vol. 22; no. 6; pp. 1519 - 1526
Main Authors:	STEINMANN, Katrin, SANDNER, Annett, SCHAGDARSURENGIN, Undraga, DAMMANN, Reinhard H
Format:	Journal Article
Language:	English
Published:	Athens Spandidos 01-12-2009
Subjects:	Adult Aged Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor DNA Methylation Epigenesis, Genetic Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Silencing Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Promoter Regions, Genetic Tumors Transcription promoter Biological marker Malignant tumor biomarker Cancerology DNA Epigenetics DNA methylation ENT disease Head and neck cancer Head and neck squamous cell carcinoma Frequency Genetics Methylation Tumor promoter Cancer Tumor suppressor gene
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