NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies

Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase considered to be the master player of cell-cycle regulation during mitosis. It is indeed involved in centrosome maturation, bipolar spindle formation, chromosome separation, and cytokinesis. PLK1 is overexpressed in a variety of human tu...

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Published in:	Molecular cancer therapeutics Vol. 11; no. 4; pp. 1006 - 1016
Main Authors:	Valsasina, Barbara, Beria, Italo, Alli, Cristina, Alzani, Rachele, Avanzi, Nilla, Ballinari, Dario, Cappella, Paolo, Caruso, Michele, Casolaro, Alessia, Ciavolella, Antonella, Cucchi, Ulisse, De Ponti, Anna, Felder, Eduard, Fiorentini, Francesco, Galvani, Arturo, Gianellini, Laura M, Giorgini, Maria L, Isacchi, Antonella, Lansen, Jaqueline, Pesenti, Enrico, Rizzi, Simona, Rocchetti, Maurizio, Sola, Francesco, Moll, Jürgen
Format:	Journal Article
Language:	English
Published:	United States 01-04-2012
Subjects:	Administration, Oral Animals Antineoplastic Agents - pharmacology Cell Cycle Proteins - antagonists & inhibitors Cell Line, Tumor Cell Proliferation - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Dogs Female Haplorhini HL-60 Cells Humans Leukemia - drug therapy Leukemia - genetics Leukemia - metabolism Leukemia - pathology Mice Mice, Nude Mice, SCID Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Polo-Like Kinase 1 Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Proto-Oncogene Proteins - antagonists & inhibitors Pyrazoles - pharmacology Quinazolines - pharmacology Rats Xenograft Model Antitumor Assays
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