Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature

• Published in: Gynecologic oncology Vol. 94; no. 3; pp. 829 - 831
• Main Authors: Rocconi, Rodney P., Leath, Charles A., Johnson, William M., Barnes, Mack N., Conner, Michael G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2004
• Subjects: Carcinoma, Large Cell - pathology; Carcinoma, Large Cell - secondary; Female; Humans; Lung Neoplasms - pathology; Metastatic lung carcinoma; Middle Aged; Vulvar lesions; Vulvar Neoplasms - pathology; Vulvar Neoplasms - secondary; Vulvar lesions; Metastatic lung carcinoma
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2004.06.006

Background. Metastatic cancer to the vulva is a rare diagnosis and is estimated to account for 5–8% of all vulvar cancers.
Case. A 57-year-old postmenopausal woman was referred for the evaluation of a new vulvar mass. CT scan of the pelvis demonstrated a 4 × 6 cm lobular mass of the left labia. An outpatient excisional biopsy revealed a poorly differentiated large cell carcinoma with prominent necrosis and focal perineural invasion consistent with a bronchogenic carcinoma. A subsequent PET scan of the chest revealed a large primary lung carcinoma confirmed by CT-guided biopsy that was identical to the vulvar tumor.
Conclusion. This case represents the only literature described primary lung carcinoma presenting as a vulvar metastasis.