Role of Surfactant Protein-A in Nitric Oxide Production and Mycoplasma Killing in Congenic C57BL/6 Mice

We generated congenic surfactant protein A (SP-A)-deficient (SP-A[-/-]) mice on the mycoplasma resistant C57BL/6 background (B6.SP-A[-/-]) and characterized their response to mycoplasma infection in comparison to C57BL/6 (B6) mice. B6.SP-A(-/-) mice infected with 10(6) colony-forming units (cfu) of...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 30; no. 3; pp. 319 - 325
Main Authors:	Hickman-Davis, Judy M, Gibbs-Erwin, Julie, Lindsey, J. Russell, Matalon, Sadis
Format:	Journal Article
Language:	English
Published:	United States Am Thoracic Soc 01-03-2004 American Thoracic Society
Subjects:	Animals Bronchoalveolar Lavage Cells, Cultured Cytokines - metabolism Genotype Lung - microbiology Mice Mice, Congenic Mice, Inbred C57BL Mice, Knockout Mycoplasma Infections - metabolism Mycoplasma pulmonis - physiology Nitrates - metabolism Nitric Oxide - biosynthesis Nitrites - metabolism Pulmonary Alveolar Proteinosis - metabolism Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein A - physiology
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