SARS Cov‐2 infection in a renal‐transplanted patient: A case report

• Published in: American journal of transplantation Vol. 20; no. 7; pp. 1882 - 1884
• Main Authors: Colaneri, Marta, Sambo, Margherita, Gallazzi, Ilaria, Roda, Silvia, Brunetti, Enrico, Zuccaro, Valentina, Pagnucco, Layla, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Sciarra, Marco, Di Filippo, Alessandro, Biscarini, Simona, Pieri, Teresa C., Sachs, Michele, Valsecchi, Pietro, Perlini, Stefano, Alfano, Claudia, Bonzano, Marco, Briganti, Federica, Crescenzi, Giuseppe, Guglielmana, Barbara, Maggi, Elena, Martino, Ilaria, Pettenazza, Pietro, Sabena, Anna, Salinaro, Francesco, Speciale, Francesco, Zunino, Ilaria, Secco, Gianmarco, Dimitry, Lorenzo, Cappa, Giovanni, Barcella, Bruno, Resta, Flavia, Moroni, Luca, Vezzoni, Giulia, Scattaglia, Lorenzo, Boscolo, Elisa, Zattera, Caterina, Vincenzo, Capozza, Vignaroli, Damiano, Bazzini, Marco, Iotti, Giorgio, Mojoli, Francesco, Belliato, Mirko, Perotti, Luciano, Tavazzi, Guido, Marseglia, Gianluigi, Licari, Amelia, Daniela, Barbarini, Patrizia, Cambieri, Giulia, Campanini, Marta, Corbella, Rossana, Daturi, Milena, Furione, Roberta, Maserati, Enza, Monzillo, Stefania, Paolucci, Francesca, Rovida, Maurizio, Zavattoni, Laura, Bellotti, Ermanna, Cabano, Giuliana, Casali, Gabriella, Garbagnoli, Alessia, Girello, Viviana, Landini, Claudia, Lucchelli, Valentina, Maliardi, Marta, Premoli, Alice, Bonetti, Giacomo, Caneva, Irene, Cassaniti, Alfonso, Corcione, Di Martino, Raffella, Di Napoli, Annapia, Alessandro, Ferrari, Guglielmo, Ferrari, Loretta, Fiorina, Alessandra, Mercato, Federica, Novazzi, Beatrice, Rossi, Maria, Sciabica I., Cerino, Antonella, Varchetta, Stefania, Mantovani, Stefania, Calvi, Monica, Tizzonis, Michela, Nicora, Carlo, Marena, Carlo, Muzzi, Alba, Comandatore, Francesco, Rettani, Marco, Band, Claudio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01-07-2020
• Subjects: Asymptomatic; Betacoronavirus; Case reports; Ceftriaxone - administration & dosage; clinical research/practice; Coronavirus Infections - complications; Coronavirus Infections - therapy; COVID-19; Cytokine storm; Cytokines - metabolism; Glomerulonephritis, IGA - complications; Glomerulonephritis, IGA - surgery; Humans; immunosuppressant – calcineurin inhibitor: tacrolimus; Immunosuppression; Immunosuppression Therapy - adverse effects; Immunosuppression Therapy - methods; infection and infectious agents – viral; Infections; infectious disease; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - surgery; Kidney Transplantation; Kidney transplants; Male; Mechanical ventilation; Middle Aged; Mycophenolic Acid - administration & dosage; Oxygenation; Pandemics; Pneumonia, Viral - complications; Pneumonia, Viral - therapy; Respiratory therapy; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Tacrolimus - administration & dosage; Treatment Outcome; immunosuppressant - calcineurin inhibitor: tacrolimus; infectious disease; infection and infectious agents - viral; clinical research/practice
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/ajt.15902

The clinical manifestation of COVID‐19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient infected with SARS CoV‐2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can “be protective” as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.
A kidney‐transplanted patient infected with SARS‐CoV‐2 shows a mild disease despite immune suppression, leading the authors to think it may be possible that immunosuppression can be protective, as the cytokine storm is an important factor in the disease story.