Basal ganglia calcification in BB/E rats with diabetes

Basal ganglia calcification in BB/E rats with diabetes

Human diabetes is associated with cognitive impairment and structural abnormalities in the brain such as cerebral atrophy. The aetiology of these abnormalities is not known. The BB/E rat is a well-established model of type 1 (insulin dependent) diabetes. A cohort of 34 BB/E rats with diabetes was di...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 12; no. 1; pp. 49 - 53
Main Authors: Lammie, G.A.., Kelly, P.A.T., Baird, J.D., Smith, W., Chatterjee, S., Frier, B.M., Strachan, M.W.J.
Format: Journal Article
Language:English
Published: Scotland Elsevier Ltd 2005
Subjects:
Actins - genetics
Actins - metabolism
Animals
Basal Ganglia - pathology
basal ganglia calcification
BB/E rats
Calcinosis - pathology
Cognition Disorders - etiology
diabetes mellitus
Diabetes Mellitus - genetics
Diabetes Mellitus - pathology
Diabetes Mellitus - psychology
Glial Fibrillary Acidic Protein - metabolism
Gliosis - pathology
Male
microangiopathy
Rats
microangiopathy
diabetes mellitus
BB/E rats
basal ganglia calcification
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Human diabetes is associated with cognitive impairment and structural abnormalities in the brain such as cerebral atrophy. The aetiology of these abnormalities is not known. The BB/E rat is a well-established model of type 1 (insulin dependent) diabetes. A cohort of 34 BB/E rats with diabetes was divided into three sub-groups according to age (and duration of diabetes). Basal ganglia calcification (BGC) was present in the brains of more than 50% of diabetic animals, but not in any of 37 non-diabetic BB/E rats. BGC occurred more commonly in those animals which had the longest duration of diabetes ( p = 0.001), such that BGC was present in only 8% of animals with diabetes for 20 weeks, but in 100% of animals with diabetes for 60 weeks. There were no other significant light microscopic neuropathologic changes in diabetic animals. It will be important to investigate the mechanism of brain calcification, whether a similar process occurs in humans with diabetes, and its possible relationship to cognitive decline.
AbstractList Human diabetes is associated with cognitive impairment and structural abnormalities in the brain such as cerebral atrophy. The aetiology of these abnormalities is not known. The BB/E rat is a well-established model of type 1 (insulin dependent) diabetes. A cohort of 34 BB/E rats with diabetes was divided into three sub-groups according to age (and duration of diabetes). Basal ganglia calcification (BGC) was present in the brains of more than 50% of diabetic animals, but not in any of 37 non-diabetic BB/E rats. BGC occurred more commonly in those animals which had the longest duration of diabetes ( p = 0.001), such that BGC was present in only 8% of animals with diabetes for 20 weeks, but in 100% of animals with diabetes for 60 weeks. There were no other significant light microscopic neuropathologic changes in diabetic animals. It will be important to investigate the mechanism of brain calcification, whether a similar process occurs in humans with diabetes, and its possible relationship to cognitive decline.
Human diabetes is associated with cognitive impairment and structural abnormalities in the brain such as cerebral atrophy. The aetiology of these abnormalities is not known. The BB/E rat is a well-established model of type 1 (insulin dependent) diabetes. A cohort of 34 BB/E rats with diabetes was divided into three sub-groups according to age (and duration of diabetes). Basal ganglia calcification (BGC) was present in the brains of more than 50% of diabetic animals, but not in any of 37 non-diabetic BB/E rats. BGC occurred more commonly in those animals which had the longest duration of diabetes (p=0.001), such that BGC was present in only 8% of animals with diabetes for 20 weeks, but in 100% of animals with diabetes for 60 weeks. There were no other significant light microscopic neuropathologic changes in diabetic animals. It will be important to investigate the mechanism of brain calcification, whether a similar process occurs in humans with diabetes, and its possible relationship to cognitive decline.
Author Smith, W.
Baird, J.D.
Chatterjee, S.
Kelly, P.A.T.
Frier, B.M.
Strachan, M.W.J.
Lammie, G.A..
Author_xml – sequence: 1
  givenname: G.A..
  surname: Lammie
  fullname: Lammie, G.A..
  email: lammiega@cardiff.ac.uk
  organization: Department of Pathology, University of Wales College of Medicine, Cardiff, UK
– sequence: 2
  givenname: P.A.T.
  surname: Kelly
  fullname: Kelly, P.A.T.
  organization: Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
– sequence: 3
  givenname: J.D.
  surname: Baird
  fullname: Baird, J.D.
  organization: Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
– sequence: 4
  givenname: W.
  surname: Smith
  fullname: Smith, W.
  organization: Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
– sequence: 5
  givenname: S.
  surname: Chatterjee
  fullname: Chatterjee, S.
  organization: Department of Pathology, University of Edinburgh, Edinburgh, UK
– sequence: 6
  givenname: B.M.
  surname: Frier
  fullname: Frier, B.M.
  organization: Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
– sequence: 7
  givenname: M.W.J.
  surname: Strachan
  fullname: Strachan, M.W.J.
  organization: Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15639413$$D View this record in MEDLINE/PubMed
BookMark eNp9kD1PwzAQQC0Eoh_wBxhQJrakZ5_tNhILrcqHVIkFZsuxL8VVmpQ4BfHvSdVKbEy3vHuneyN2Xjc1MXbDIePA9WSTbRpXZwJAZoAZCH3GhlyhSIVWeM6GkOtpqmZ6NmCjGDcAkEuESzbgSmMuOQ6Znttoq2Rt63UVbOJs5UIZnO1CUyehTubzyTJpbReT79B9JD7YgjqKV-yitFWk69Mcs_fH5dviOV29Pr0sHlapQyW7tBClRCElKK0UWJ_nsuRCwqzEwnNXeIVgBfYsoRZS-SnmmjiJ_hf0IHHM7o7eXdt87il2Zhuio6qyNTX7aPQU5bQX9KA4gq5tYmypNLs2bG37YziYQy2zMYda5lDLAJrDhTG7Pdn3xZb838opTw_cHwHqf_wK1JroAtWOfGjJdcY34T__L-XLeeY
CitedBy_id crossref_primary_10_31832_smj_693271
crossref_primary_10_1089_neu_2008_0553
crossref_primary_10_1177_1533317514534758
crossref_primary_10_1016_j_neurad_2018_07_005
crossref_primary_10_1111_j_1464_5491_2010_03199_x
crossref_primary_10_1371_journal_pone_0205797
Cites_doi 10.1159/000213342
10.1136/jnnp.44.12.1168
10.1136/jnnp.74.1.70
10.1097/00005053-195011130-00001
10.1161/01.STR.30.10.2183
10.1007/BF01212229
10.2337/diabetes.36.5.597
10.1007/s004010051072
10.2337/diacare.23.10.1486
10.1007/BF00689598
10.1007/BF00417687
10.1097/00005053-199101000-00010
10.1210/edrv-9-3-346
10.1016/S0006-8993(02)02887-1
10.1136/jnnp.56.6.622
10.2337/diacare.20.6.1013
10.1016/0197-4580(92)90095-F
10.2337/diabetes.31.4.313
10.1007/BF01257917
10.2337/diabetes.42.2.341
10.1148/radiology.134.1.7350641
10.1007/BF00279127
10.1006/nbdi.2000.0332
10.1161/01.STR.31.11.2701
10.1177/096120339600500207
10.1001/archopht.1996.01100130302013
10.1046/j.1464-5491.1999.00027.x
10.1097/00005072-197304000-00001
10.1007/BF00688853
10.2337/diacare.20.3.438
10.2337/diabetes.41.5.557
10.2337/diacare.11.1.86
10.1016/S0736-5748(99)00098-2
10.1007/BF00686999
ContentType Journal Article
Copyright 2004 Elsevier Ltd
Copyright_xml – notice: 2004 Elsevier Ltd
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.jocn.2004.03.026
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: ECM
  name: MEDLINE
  url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1532-2653
EndPage 53
ExternalDocumentID 10_1016_j_jocn_2004_03_026
15639413
S0967586804002607
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
--K
--M
-RU
.1-
.FO
.~1
0R~
1B1
1P~
1RT
1~.
1~5
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AACTN
AADPK
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXLA
AAXUO
ABBQC
ABCQJ
ABFNM
ABJNI
ABLVK
ABMAC
ABMZM
ABTEW
ABXDB
ABYKQ
ACDAQ
ACGFS
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEKER
AENEX
AEVXI
AFCTW
AFKWA
AFRHN
AFTJW
AFXIZ
AGHFR
AGUBO
AGWIK
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
AJUYK
AKRLJ
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CAG
COF
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HDW
HMK
HMO
HVGLF
HZ~
IHE
J1W
KOM
LCYCR
LX8
M29
M41
MO0
MOBAO
N9A
O-L
O9-
OAUVE
OP~
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SAE
SCC
SDF
SDG
SEL
SES
SEW
SPCBC
SSH
SSN
SSZ
T5K
UHS
WUQ
Z5R
~G-
AAXKI
AFJKZ
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c354t-b2f43244056550ad994f12408f3bd1cbd530a23354e36245d7396e1e20263d043
ISSN 0967-5868
IngestDate Thu Oct 24 22:32:58 EDT 2024
Thu Sep 26 16:24:06 EDT 2024
Sat Sep 28 07:46:15 EDT 2024
Fri Feb 23 02:28:41 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords microangiopathy
diabetes mellitus
BB/E rats
basal ganglia calcification
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c354t-b2f43244056550ad994f12408f3bd1cbd530a23354e36245d7396e1e20263d043
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 15639413
PQID 67347233
PQPubID 23479
PageCount 5
ParticipantIDs proquest_miscellaneous_67347233
crossref_primary_10_1016_j_jocn_2004_03_026
pubmed_primary_15639413
elsevier_sciencedirect_doi_10_1016_j_jocn_2004_03_026
PublicationCentury 2000
PublicationDate 2005
2005-Jan
2005-1-00
20050101
PublicationDateYYYYMMDD 2005-01-01
PublicationDate_xml – year: 2005
  text: 2005
PublicationDecade 2000
PublicationPlace Scotland
PublicationPlace_xml – name: Scotland
PublicationTitle Journal of clinical neuroscience
PublicationTitleAlternate J Clin Neurosci
PublicationYear 2005
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Li, Zhang, Grunberger, Sima (bib18) 2002; 946
Olsson, Save-Soderbergh, Sourander, Angervall (bib10) 1968; 3
Ryan, Geckle (bib4) 2000; 23
Johnson, Brendel, Meezan (bib11) 1982; 106
Mooradian (bib30) 1988; 9
Perros, Deary, Sellar, Best, Frier (bib7) 1997; 20
Ryan (bib3) 1998; 11
Elder, Maclaren, Riley, McConnell (bib39) 1982; 31
Anderson (bib21) 1983; 107
Biessels, Kappelle, Bravenboer, Erkelens, Gispen (bib32) 1994; 37
Kern, Engerman (bib17) 1996; 114
Pirttila, Jarvenpaa, Laippala, Frey (bib5) 1992; 38
Mukai, Hori, Pomeroy (bib12) 1980; 51
Toung, Hurn, Traystman, Sieber (bib36) 2000; 31
Everhart, Pettit, Knowler, Rose, Bennett (bib29) 1988; 31
Aronson (bib34) 1973; 32
Jakobsen, Sidenius, Gundersen, Osterby (bib16) 1987; 36
Reske-Nielsen, Lundbaek, Rafaelsen (bib9) 1965; 1
Luse, Gerritsen, Dulin (bib35) 1970; 6
Mahy, Prats, Riveros, Andres, Bernal (bib37) 1999; 98
Mann (bib26) 1988; 76
Soininen, Puranen, Helkala, Laakso, Riekkinen (bib6) 1992; 13
Fenelon, Gray, Thiebierge, Mahieux, Guillard (bib25) 1993; 56
Heron, Hernigou, Chatellier, Fornes, Emmerich, Fiessinger (bib23) 1999; 30
Raymond, Zariah AASamad, Chin, Kong (bib24) 1996; 5
Rosenberg, Neylan, El-Awar, Peters, van Kammen (bib41) 1991; 179
Starr, Wardlaw, Ferguson, MacLullich, Deary, Marshall (bib40) 2003; 74
Stewart, Liolitsa (bib2) 1999; 16
Deary, Crawford, Hepburn, Langan, Blackmore, Frier (bib8) 1993; 42
Reske-Nielsen, Lundbaek (bib33) 1963
Baird (bib19) 1989
Cohen, Duchesneau, Weinstein (bib20) 1980; 134
McCall (bib31) 1992; 41
Lowenthal (bib15) 1986
Junker, Jaggi, Bestetti, Rossi (bib14) 1985; 65
Rodriguez, Bernal, Andres, Malpesa, Maty (bib38) 2000; 18
Strachan, Deary, Ewing, Frier (bib1) 1997; 20
Harrington, MacPherson, McIntosh, Allam, Bone (bib22) 1981; 44
Rodriguez, Ursu, Bernal, Cusi, Maty (bib27) 2001; 8
McCuskey, McCuskey (bib13) 1984; 1
DeJong (bib28) 1950; 3
McCall (10.1016/j.jocn.2004.03.026_bib31) 1992; 41
Lowenthal (10.1016/j.jocn.2004.03.026_bib15) 1986
Cohen (10.1016/j.jocn.2004.03.026_bib20) 1980; 134
Johnson (10.1016/j.jocn.2004.03.026_bib11) 1982; 106
Toung (10.1016/j.jocn.2004.03.026_bib36) 2000; 31
Soininen (10.1016/j.jocn.2004.03.026_bib6) 1992; 13
McCuskey (10.1016/j.jocn.2004.03.026_bib13) 1984; 1
Mooradian (10.1016/j.jocn.2004.03.026_bib30) 1988; 9
Biessels (10.1016/j.jocn.2004.03.026_bib32) 1994; 37
Anderson (10.1016/j.jocn.2004.03.026_bib21) 1983; 107
Everhart (10.1016/j.jocn.2004.03.026_bib29) 1988; 31
Reske-Nielsen (10.1016/j.jocn.2004.03.026_bib9) 1965; 1
Heron (10.1016/j.jocn.2004.03.026_bib23) 1999; 30
Li (10.1016/j.jocn.2004.03.026_bib18) 2002; 946
Junker (10.1016/j.jocn.2004.03.026_bib14) 1985; 65
Stewart (10.1016/j.jocn.2004.03.026_bib2) 1999; 16
Starr (10.1016/j.jocn.2004.03.026_bib40) 2003; 74
Pirttila (10.1016/j.jocn.2004.03.026_bib5) 1992; 38
Olsson (10.1016/j.jocn.2004.03.026_bib10) 1968; 3
Harrington (10.1016/j.jocn.2004.03.026_bib22) 1981; 44
Rodriguez (10.1016/j.jocn.2004.03.026_bib27) 2001; 8
Ryan (10.1016/j.jocn.2004.03.026_bib4) 2000; 23
Baird (10.1016/j.jocn.2004.03.026_bib19) 1989
Raymond (10.1016/j.jocn.2004.03.026_bib24) 1996; 5
Perros (10.1016/j.jocn.2004.03.026_bib7) 1997; 20
Jakobsen (10.1016/j.jocn.2004.03.026_bib16) 1987; 36
Reske-Nielsen (10.1016/j.jocn.2004.03.026_bib33) 1963
Luse (10.1016/j.jocn.2004.03.026_bib35) 1970; 6
DeJong (10.1016/j.jocn.2004.03.026_bib28) 1950; 3
Ryan (10.1016/j.jocn.2004.03.026_bib3) 1998; 11
Deary (10.1016/j.jocn.2004.03.026_bib8) 1993; 42
Mukai (10.1016/j.jocn.2004.03.026_bib12) 1980; 51
Fenelon (10.1016/j.jocn.2004.03.026_bib25) 1993; 56
Strachan (10.1016/j.jocn.2004.03.026_bib1) 1997; 20
Kern (10.1016/j.jocn.2004.03.026_bib17) 1996; 114
Rodriguez (10.1016/j.jocn.2004.03.026_bib38) 2000; 18
Elder (10.1016/j.jocn.2004.03.026_bib39) 1982; 31
Aronson (10.1016/j.jocn.2004.03.026_bib34) 1973; 32
Mahy (10.1016/j.jocn.2004.03.026_bib37) 1999; 98
Rosenberg (10.1016/j.jocn.2004.03.026_bib41) 1991; 179
Mann (10.1016/j.jocn.2004.03.026_bib26) 1988; 76
References_xml – volume: 30
  start-page: 2183
  year: 1999
  end-page: 2185
  ident: bib23
  article-title: Intracerebral calcification in systemic sclerosis
  publication-title: Stroke
  contributor:
    fullname: Fiessinger
– volume: 106
  start-page: 214
  year: 1982
  end-page: 217
  ident: bib11
  article-title: Thickened cerebral cortical capillary basement membrane in diabetics
  publication-title: Arch. Pathol. Lab. Med.
  contributor:
    fullname: Meezan
– volume: 65
  start-page: 202
  year: 1985
  end-page: 208
  ident: bib14
  article-title: Basement membrane of hypothalamus and cortex capillaries from normotensive and spontaneously hypertensive rats with streptozotocin-induced diabetes
  publication-title: Acta Neuropathol.
  contributor:
    fullname: Rossi
– volume: 56
  start-page: 622
  year: 1993
  end-page: 625
  ident: bib25
  article-title: A prospective study of patients with pallidal calcifications
  publication-title: J. Neurol. Neurosurg. Psychiatry
  contributor:
    fullname: Guillard
– volume: 37
  start-page: 643
  year: 1994
  end-page: 650
  ident: bib32
  article-title: Cerebral function in diabetes mellitus
  publication-title: Diabetalogia
  contributor:
    fullname: Gispen
– volume: 11
  start-page: 86
  year: 1998
  end-page: 93
  ident: bib3
  article-title: Neurobehavioral complications of Type 1 diabetes. Examination of possible risk factors
  publication-title: Diabetes Care
  contributor:
    fullname: Ryan
– volume: 179
  start-page: 48
  year: 1991
  end-page: 49
  ident: bib41
  article-title: Neuropsychiatric symptoms associated with idiopathic calcification of the basal ganglia
  publication-title: J. Nerv. Ment. Dis.
  contributor:
    fullname: van Kammen
– volume: 1
  start-page: 233
  year: 1965
  end-page: 241
  ident: bib9
  article-title: Pathological changes in the central and peripheral nervous system of young long-term diabetics. I. Diabetic encephalopathy
  publication-title: Diabetologia
  contributor:
    fullname: Rafaelsen
– volume: 946
  start-page: 221
  year: 2002
  end-page: 231
  ident: bib18
  article-title: Hippocampal neuronal apoptosis in type 1 diabetes
  publication-title: Brain Res.
  contributor:
    fullname: Sima
– volume: 5
  start-page: 123
  year: 1996
  end-page: 128
  ident: bib24
  article-title: Brain calcification in patients with cerebral lupus
  publication-title: Lupus
  contributor:
    fullname: Kong
– start-page: 417
  year: 1986
  end-page: 436
  ident: bib15
  article-title: Striatopallidodentate calcifications
  publication-title: Handbook of Clinical Neurology
  contributor:
    fullname: Lowenthal
– volume: 31
  start-page: 313
  year: 1982
  end-page: 318
  ident: bib39
  article-title: Gastric parietal cell and other autoantibodies in the BB rat
  publication-title: Diabetes
  contributor:
    fullname: McConnell
– volume: 76
  start-page: 595
  year: 1988
  end-page: 598
  ident: bib26
  article-title: Calcification of the basal ganglia in Down’s syndrome and Alzheimer’s disease
  publication-title: Acta Neuropathol.
  contributor:
    fullname: Mann
– volume: 3
  start-page: 62
  year: 1968
  end-page: 79
  ident: bib10
  article-title: A patho-anatomical study of the central and peripheral nervous system in diabetes of early onset and long duration
  publication-title: Path. Europ.
  contributor:
    fullname: Angervall
– volume: 18
  start-page: 299
  year: 2000
  end-page: 307
  ident: bib38
  article-title: Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation
  publication-title: Int. J. Dev. Neurosci.
  contributor:
    fullname: Maty
– volume: 31
  start-page: 16
  year: 1988
  end-page: 23
  ident: bib29
  article-title: Medial arterial calcification and its association with mortality and complications of diabetes
  publication-title: Diabetologia
  contributor:
    fullname: Bennett
– volume: 23
  start-page: 1468
  year: 2000
  end-page: 1493
  ident: bib4
  article-title: Circumscribed cognitive dysfunction in middle-aged adults with Type 2 diabetes
  publication-title: Diabetes Care
  contributor:
    fullname: Geckle
– volume: 114
  start-page: 306
  year: 1996
  end-page: 310
  ident: bib17
  article-title: Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia
  publication-title: Arch. Opthalmol.
  contributor:
    fullname: Engerman
– volume: 134
  start-page: 97
  year: 1980
  end-page: 99
  ident: bib20
  article-title: Calcification of the basal ganglia as visualised by computed tomography
  publication-title: Radiology
  contributor:
    fullname: Weinstein
– volume: 1
  start-page: 221
  year: 1984
  end-page: 244
  ident: bib13
  article-title: In vivo and electron microscopic study of the development of cerebral diabetic microangiopathy
  publication-title: Microcirculation, Endothelium and Lymphatics
  contributor:
    fullname: McCuskey
– volume: 38
  start-page: 285
  year: 1992
  end-page: 291
  ident: bib5
  article-title: Brain atrophy on computerized axial tomography scans: interaction of age, diabetes and general morbidity
  publication-title: Gerontology
  contributor:
    fullname: Frey
– volume: 36
  start-page: 597
  year: 1987
  end-page: 601
  ident: bib16
  article-title: Quantitative changes of cerebral neocortical structure in insulin-treated long-term streptozocin-induced diabetes in rats
  publication-title: Diabetes
  contributor:
    fullname: Osterby
– volume: 32
  start-page: 183
  year: 1973
  end-page: 196
  ident: bib34
  article-title: Intracranial vascular lesions in patients with diabetes mellitus
  publication-title: J. Neuropathol. Exp. Neurol.
  contributor:
    fullname: Aronson
– volume: 107
  start-page: 341
  year: 1983
  end-page: 348
  ident: bib21
  article-title: Calcific lesions: a concept
  publication-title: Arch. Pathol. Lab. Med.
  contributor:
    fullname: Anderson
– volume: 31
  start-page: 2701
  year: 2000
  end-page: 2706
  ident: bib36
  article-title: Estrogen decreases infarct size after temporary focal ischemia in a genetic model of Type 1 diabetes mellitus
  publication-title: Stroke
  contributor:
    fullname: Sieber
– volume: 6
  start-page: 192
  year: 1970
  end-page: 198
  ident: bib35
  article-title: Cerebral abnormalities in diabetes mellitus: an ultrastructural study of the brain in early onset diabetes mellitus in the Chinese hamster
  publication-title: Diabetologia
  contributor:
    fullname: Dulin
– volume: 41
  start-page: 557
  year: 1992
  end-page: 570
  ident: bib31
  article-title: The impact of diabetes on the CNS
  publication-title: Diabetes
  contributor:
    fullname: McCall
– volume: 44
  start-page: 1168
  year: 1981
  end-page: 1170
  ident: bib22
  article-title: The significance of the incidental finding of basal ganglia calcification on computed tomography
  publication-title: J. Neurol. Neurosurg. Psychiatry
  contributor:
    fullname: Bone
– volume: 51
  start-page: 79
  year: 1980
  end-page: 84
  ident: bib12
  article-title: Cerebral lesions in rats with streptozotocin-induced diabetes
  publication-title: Acta Neuropathol.
  contributor:
    fullname: Pomeroy
– volume: 3
  start-page: 181
  year: 1950
  end-page: 207
  ident: bib28
  article-title: The nervous system complications of diabetes mellitus, with special reference to cerebrovascular changes
  publication-title: J. Nerv. Ment. Dis.
  contributor:
    fullname: DeJong
– volume: 9
  start-page: 346
  year: 1988
  end-page: 356
  ident: bib30
  article-title: Diabetic complications of the central nervous system
  publication-title: Endocrine Rev.
  contributor:
    fullname: Mooradian
– volume: 74
  start-page: 70
  year: 2003
  end-page: 76
  ident: bib40
  article-title: Increased blood–brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging
  publication-title: J. Neurol. Neurosurg. Psychiatry
  contributor:
    fullname: Marshall
– start-page: 253
  year: 1989
  end-page: 280
  ident: bib19
  article-title: Relevance of the BB rat as a model for human insulin-dependent (Type1) diabetes mellitus
  publication-title: Recent Advances in Endocrinology and Metabolism
  contributor:
    fullname: Baird
– volume: 8
  start-page: 59
  year: 2001
  end-page: 68
  ident: bib27
  article-title: Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification
  publication-title: Neurobiol. Dis.
  contributor:
    fullname: Maty
– volume: 20
  start-page: 438
  year: 1997
  end-page: 445
  ident: bib1
  article-title: Is Type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies
  publication-title: Diabetes Care
  contributor:
    fullname: Frier
– volume: 13
  start-page: 717
  year: 1992
  end-page: 721
  ident: bib6
  article-title: Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population
  publication-title: Neurobiol. Aging
  contributor:
    fullname: Riekkinen
– start-page: 273
  year: 1963
  end-page: 290
  ident: bib33
  article-title: Diabetic encephalopathy. Diffuse and focal lesions of the brain in long-term diabetes
  publication-title: Acta Neurol. Scand.
  contributor:
    fullname: Lundbaek
– volume: 42
  start-page: 341
  year: 1993
  end-page: 344
  ident: bib8
  article-title: Severe hypoglycemia and intelligence in adult patients with insulin-treated diabetes
  publication-title: Diabetes
  contributor:
    fullname: Frier
– volume: 98
  start-page: 217
  year: 1999
  end-page: 225
  ident: bib37
  article-title: Basal ganglia calcification induced by excitotoxicity: an experimental model characterised by electron microscopy and X-ray microanalysis
  publication-title: Acta Neuropathol.
  contributor:
    fullname: Bernal
– volume: 20
  start-page: 1013
  year: 1997
  end-page: 1018
  ident: bib7
  article-title: Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of severe hypoglycemia
  publication-title: Diabetes Care
  contributor:
    fullname: Frier
– volume: 16
  start-page: 93
  year: 1999
  end-page: 112
  ident: bib2
  article-title: Type 2 diabetes mellitus, cognitive impairment and dementia
  publication-title: Diabetic Med.
  contributor:
    fullname: Liolitsa
– volume: 38
  start-page: 285
  year: 1992
  ident: 10.1016/j.jocn.2004.03.026_bib5
  article-title: Brain atrophy on computerized axial tomography scans: interaction of age, diabetes and general morbidity
  publication-title: Gerontology
  doi: 10.1159/000213342
  contributor:
    fullname: Pirttila
– volume: 44
  start-page: 1168
  year: 1981
  ident: 10.1016/j.jocn.2004.03.026_bib22
  article-title: The significance of the incidental finding of basal ganglia calcification on computed tomography
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp.44.12.1168
  contributor:
    fullname: Harrington
– volume: 74
  start-page: 70
  year: 2003
  ident: 10.1016/j.jocn.2004.03.026_bib40
  article-title: Increased blood–brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp.74.1.70
  contributor:
    fullname: Starr
– start-page: 417
  year: 1986
  ident: 10.1016/j.jocn.2004.03.026_bib15
  article-title: Striatopallidodentate calcifications
  contributor:
    fullname: Lowenthal
– volume: 3
  start-page: 181
  year: 1950
  ident: 10.1016/j.jocn.2004.03.026_bib28
  article-title: The nervous system complications of diabetes mellitus, with special reference to cerebrovascular changes
  publication-title: J. Nerv. Ment. Dis.
  doi: 10.1097/00005053-195011130-00001
  contributor:
    fullname: DeJong
– volume: 30
  start-page: 2183
  year: 1999
  ident: 10.1016/j.jocn.2004.03.026_bib23
  article-title: Intracerebral calcification in systemic sclerosis
  publication-title: Stroke
  doi: 10.1161/01.STR.30.10.2183
  contributor:
    fullname: Heron
– volume: 6
  start-page: 192
  year: 1970
  ident: 10.1016/j.jocn.2004.03.026_bib35
  article-title: Cerebral abnormalities in diabetes mellitus: an ultrastructural study of the brain in early onset diabetes mellitus in the Chinese hamster
  publication-title: Diabetologia
  doi: 10.1007/BF01212229
  contributor:
    fullname: Luse
– volume: 36
  start-page: 597
  year: 1987
  ident: 10.1016/j.jocn.2004.03.026_bib16
  article-title: Quantitative changes of cerebral neocortical structure in insulin-treated long-term streptozocin-induced diabetes in rats
  publication-title: Diabetes
  doi: 10.2337/diabetes.36.5.597
  contributor:
    fullname: Jakobsen
– volume: 98
  start-page: 217
  year: 1999
  ident: 10.1016/j.jocn.2004.03.026_bib37
  article-title: Basal ganglia calcification induced by excitotoxicity: an experimental model characterised by electron microscopy and X-ray microanalysis
  publication-title: Acta Neuropathol.
  doi: 10.1007/s004010051072
  contributor:
    fullname: Mahy
– volume: 23
  start-page: 1468
  year: 2000
  ident: 10.1016/j.jocn.2004.03.026_bib4
  article-title: Circumscribed cognitive dysfunction in middle-aged adults with Type 2 diabetes
  publication-title: Diabetes Care
  doi: 10.2337/diacare.23.10.1486
  contributor:
    fullname: Ryan
– volume: 76
  start-page: 595
  year: 1988
  ident: 10.1016/j.jocn.2004.03.026_bib26
  article-title: Calcification of the basal ganglia in Down’s syndrome and Alzheimer’s disease
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00689598
  contributor:
    fullname: Mann
– volume: 37
  start-page: 643
  year: 1994
  ident: 10.1016/j.jocn.2004.03.026_bib32
  article-title: Cerebral function in diabetes mellitus
  publication-title: Diabetalogia
  doi: 10.1007/BF00417687
  contributor:
    fullname: Biessels
– volume: 179
  start-page: 48
  year: 1991
  ident: 10.1016/j.jocn.2004.03.026_bib41
  article-title: Neuropsychiatric symptoms associated with idiopathic calcification of the basal ganglia
  publication-title: J. Nerv. Ment. Dis.
  doi: 10.1097/00005053-199101000-00010
  contributor:
    fullname: Rosenberg
– volume: 9
  start-page: 346
  year: 1988
  ident: 10.1016/j.jocn.2004.03.026_bib30
  article-title: Diabetic complications of the central nervous system
  publication-title: Endocrine Rev.
  doi: 10.1210/edrv-9-3-346
  contributor:
    fullname: Mooradian
– volume: 946
  start-page: 221
  year: 2002
  ident: 10.1016/j.jocn.2004.03.026_bib18
  article-title: Hippocampal neuronal apoptosis in type 1 diabetes
  publication-title: Brain Res.
  doi: 10.1016/S0006-8993(02)02887-1
  contributor:
    fullname: Li
– volume: 56
  start-page: 622
  year: 1993
  ident: 10.1016/j.jocn.2004.03.026_bib25
  article-title: A prospective study of patients with pallidal calcifications
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp.56.6.622
  contributor:
    fullname: Fenelon
– start-page: 273
  issue: Suppl 4
  year: 1963
  ident: 10.1016/j.jocn.2004.03.026_bib33
  article-title: Diabetic encephalopathy. Diffuse and focal lesions of the brain in long-term diabetes
  publication-title: Acta Neurol. Scand.
  contributor:
    fullname: Reske-Nielsen
– volume: 1
  start-page: 221
  year: 1984
  ident: 10.1016/j.jocn.2004.03.026_bib13
  article-title: In vivo and electron microscopic study of the development of cerebral diabetic microangiopathy
  publication-title: Microcirculation, Endothelium and Lymphatics
  contributor:
    fullname: McCuskey
– volume: 20
  start-page: 1013
  year: 1997
  ident: 10.1016/j.jocn.2004.03.026_bib7
  article-title: Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of severe hypoglycemia
  publication-title: Diabetes Care
  doi: 10.2337/diacare.20.6.1013
  contributor:
    fullname: Perros
– volume: 13
  start-page: 717
  year: 1992
  ident: 10.1016/j.jocn.2004.03.026_bib6
  article-title: Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population
  publication-title: Neurobiol. Aging
  doi: 10.1016/0197-4580(92)90095-F
  contributor:
    fullname: Soininen
– volume: 106
  start-page: 214
  year: 1982
  ident: 10.1016/j.jocn.2004.03.026_bib11
  article-title: Thickened cerebral cortical capillary basement membrane in diabetics
  publication-title: Arch. Pathol. Lab. Med.
  contributor:
    fullname: Johnson
– volume: 31
  start-page: 313
  year: 1982
  ident: 10.1016/j.jocn.2004.03.026_bib39
  article-title: Gastric parietal cell and other autoantibodies in the BB rat
  publication-title: Diabetes
  doi: 10.2337/diabetes.31.4.313
  contributor:
    fullname: Elder
– volume: 1
  start-page: 233
  year: 1965
  ident: 10.1016/j.jocn.2004.03.026_bib9
  article-title: Pathological changes in the central and peripheral nervous system of young long-term diabetics. I. Diabetic encephalopathy
  publication-title: Diabetologia
  doi: 10.1007/BF01257917
  contributor:
    fullname: Reske-Nielsen
– volume: 42
  start-page: 341
  year: 1993
  ident: 10.1016/j.jocn.2004.03.026_bib8
  article-title: Severe hypoglycemia and intelligence in adult patients with insulin-treated diabetes
  publication-title: Diabetes
  doi: 10.2337/diabetes.42.2.341
  contributor:
    fullname: Deary
– volume: 107
  start-page: 341
  year: 1983
  ident: 10.1016/j.jocn.2004.03.026_bib21
  article-title: Calcific lesions: a concept
  publication-title: Arch. Pathol. Lab. Med.
  contributor:
    fullname: Anderson
– volume: 134
  start-page: 97
  year: 1980
  ident: 10.1016/j.jocn.2004.03.026_bib20
  article-title: Calcification of the basal ganglia as visualised by computed tomography
  publication-title: Radiology
  doi: 10.1148/radiology.134.1.7350641
  contributor:
    fullname: Cohen
– volume: 31
  start-page: 16
  year: 1988
  ident: 10.1016/j.jocn.2004.03.026_bib29
  article-title: Medial arterial calcification and its association with mortality and complications of diabetes
  publication-title: Diabetologia
  doi: 10.1007/BF00279127
  contributor:
    fullname: Everhart
– volume: 8
  start-page: 59
  year: 2001
  ident: 10.1016/j.jocn.2004.03.026_bib27
  article-title: Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification
  publication-title: Neurobiol. Dis.
  doi: 10.1006/nbdi.2000.0332
  contributor:
    fullname: Rodriguez
– volume: 31
  start-page: 2701
  year: 2000
  ident: 10.1016/j.jocn.2004.03.026_bib36
  article-title: Estrogen decreases infarct size after temporary focal ischemia in a genetic model of Type 1 diabetes mellitus
  publication-title: Stroke
  doi: 10.1161/01.STR.31.11.2701
  contributor:
    fullname: Toung
– volume: 3
  start-page: 62
  year: 1968
  ident: 10.1016/j.jocn.2004.03.026_bib10
  article-title: A patho-anatomical study of the central and peripheral nervous system in diabetes of early onset and long duration
  publication-title: Path. Europ.
  contributor:
    fullname: Olsson
– start-page: 253
  year: 1989
  ident: 10.1016/j.jocn.2004.03.026_bib19
  article-title: Relevance of the BB rat as a model for human insulin-dependent (Type1) diabetes mellitus
  contributor:
    fullname: Baird
– volume: 5
  start-page: 123
  year: 1996
  ident: 10.1016/j.jocn.2004.03.026_bib24
  article-title: Brain calcification in patients with cerebral lupus
  publication-title: Lupus
  doi: 10.1177/096120339600500207
  contributor:
    fullname: Raymond
– volume: 114
  start-page: 306
  year: 1996
  ident: 10.1016/j.jocn.2004.03.026_bib17
  article-title: Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia
  publication-title: Arch. Opthalmol.
  doi: 10.1001/archopht.1996.01100130302013
  contributor:
    fullname: Kern
– volume: 16
  start-page: 93
  year: 1999
  ident: 10.1016/j.jocn.2004.03.026_bib2
  article-title: Type 2 diabetes mellitus, cognitive impairment and dementia
  publication-title: Diabetic Med.
  doi: 10.1046/j.1464-5491.1999.00027.x
  contributor:
    fullname: Stewart
– volume: 32
  start-page: 183
  year: 1973
  ident: 10.1016/j.jocn.2004.03.026_bib34
  article-title: Intracranial vascular lesions in patients with diabetes mellitus
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/00005072-197304000-00001
  contributor:
    fullname: Aronson
– volume: 51
  start-page: 79
  year: 1980
  ident: 10.1016/j.jocn.2004.03.026_bib12
  article-title: Cerebral lesions in rats with streptozotocin-induced diabetes
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00688853
  contributor:
    fullname: Mukai
– volume: 20
  start-page: 438
  year: 1997
  ident: 10.1016/j.jocn.2004.03.026_bib1
  article-title: Is Type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies
  publication-title: Diabetes Care
  doi: 10.2337/diacare.20.3.438
  contributor:
    fullname: Strachan
– volume: 41
  start-page: 557
  year: 1992
  ident: 10.1016/j.jocn.2004.03.026_bib31
  article-title: The impact of diabetes on the CNS
  publication-title: Diabetes
  doi: 10.2337/diabetes.41.5.557
  contributor:
    fullname: McCall
– volume: 11
  start-page: 86
  year: 1998
  ident: 10.1016/j.jocn.2004.03.026_bib3
  article-title: Neurobehavioral complications of Type 1 diabetes. Examination of possible risk factors
  publication-title: Diabetes Care
  doi: 10.2337/diacare.11.1.86
  contributor:
    fullname: Ryan
– volume: 18
  start-page: 299
  year: 2000
  ident: 10.1016/j.jocn.2004.03.026_bib38
  article-title: Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation
  publication-title: Int. J. Dev. Neurosci.
  doi: 10.1016/S0736-5748(99)00098-2
  contributor:
    fullname: Rodriguez
– volume: 65
  start-page: 202
  year: 1985
  ident: 10.1016/j.jocn.2004.03.026_bib14
  article-title: Basement membrane of hypothalamus and cortex capillaries from normotensive and spontaneously hypertensive rats with streptozotocin-induced diabetes
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00686999
  contributor:
    fullname: Junker
SSID ssj0009430
Score 1.7735778
Snippet Human diabetes is associated with cognitive impairment and structural abnormalities in the brain such as cerebral atrophy. The aetiology of these abnormalities...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 49
SubjectTerms Actins - genetics
Actins - metabolism
Animals
Basal Ganglia - pathology
basal ganglia calcification
BB/E rats
Calcinosis - pathology
Cognition Disorders - etiology
diabetes mellitus
Diabetes Mellitus - genetics
Diabetes Mellitus - pathology
Diabetes Mellitus - psychology
Glial Fibrillary Acidic Protein - metabolism
Gliosis - pathology
Male
microangiopathy
Rats
Title Basal ganglia calcification in BB/E rats with diabetes
URI https://dx.doi.org/10.1016/j.jocn.2004.03.026
https://www.ncbi.nlm.nih.gov/pubmed/15639413
https://search.proquest.com/docview/67347233
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9swELcGSBMvCDbGytf8wFuVrLWdOH1saIChMSHRCd4iJ3YmKpEiSv9_zl8JUHUaSHuJKqtx7LufLufL3e8QOoqSsiJVEQdcSBYwQatAKCICKpKC6-y1wvQ6PLviv26SUcayNq2oHfuvmoYx0LWunH2DtptJYQB-g87hClqH6z_pPRUzkPofoctzRRc0YJLuhM9pTFOYOuuC3l1dmw--LvFSm8rJZ8SXDRZ-irs7-33jNByGYWu8Xf_qSxgdN8OpuLV59OfhqBlsIjvX4YsARNTGw3xNTJuAZAKLYHqjxDbLCZU3qyQgsaUFbuwuWcCXNaKWw9S9ju09C4bexhwm4WRaGhZbZqhqyStWbfOevtIr0gvS9gqOb3wFrREwS2AV14Y_spvzlqSZmd40zQ5ckZXNB3z9pGWOzLKDinFYxptow-kQDy1EttAHVX9CHy9cLsVnFBukYIcU_AIp-LbGafo9wxonWOMEe5xso98n2fj4LHBdNIKSRuwxKEilWRfBMY_hNCrkYMCqvia2q2gh-2UhI9oThMJ_FTgzLJKcDmLVVwT2SGWP0S9otZ7W6ivCsRSxov1KESnZQPKCk7IHB3jFdY_VRHVQ14skv7dkKbnPIpzkWoC66ynLezSHyTso8lLLHXytG5eDkv963zcv4hxsof7AJWo1nc90jiLjsJUO2rGSb1cRgScO_truO5-5h9YNZ6-Jve2j1ceHuTpAKzM5P3QgegKy6YQg
link.rule.ids 315,782,786,4029,27933,27934,27935
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Basal+ganglia+calcification+in+BB%2FE+rats+with+diabetes&rft.jtitle=Journal+of+clinical+neuroscience&rft.au=Lammie%2C+G.A..&rft.au=Kelly%2C+P.A.T.&rft.au=Baird%2C+J.D.&rft.au=Smith%2C+W.&rft.date=2005&rft.pub=Elsevier+Ltd&rft.issn=0967-5868&rft.eissn=1532-2653&rft.volume=12&rft.issue=1&rft.spage=49&rft.epage=53&rft_id=info:doi/10.1016%2Fj.jocn.2004.03.026&rft.externalDocID=S0967586804002607
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0967-5868&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0967-5868&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0967-5868&client=summon