Alleviating effects of Opuntia ficus indica extracts on psychomotor alterations induced by ethanol in rats

• Published in: Food science and biotechnology Vol. 23; no. 6; pp. 2063 - 2068
• Main Authors: dela Peña, Irene Joy I., Yoon, Seo Young, Kim, Hee Jin, Shim, Hong, Kim, Ji Hyoung, Cheong, Narae, Paek, Se Hee, Seo, Yong Ki, Park, Seok Jun, Moon, Byoung Seok, Cheong, Jae Hoon
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society of Food Science and Technology 01-12-2014; 한국식품과학회
• Subjects: Chemistry; Chemistry and Materials Science; Ficus; Food Science; Nutrition; Opuntia; Research Article; 식품과학; psychomotor alteration; ethanol; electroencephalogram
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-014-0280-4

Effects of
Opuntia ficus indica
(OFI) extracts on ethanol-induced psychomotor alterations were studied using Sprague-Dawley rats orally administered 4 g/kg of ethanol (EtOH group) or distilled water (control group). An OFI-group received OFI extracts (50, 100, and 200 mg/kg) 30 min prior to EtOH administration. Behavioral and hematological tests were evaluated 1, 2, 4, and 8 h after EtOH administration. Electroencephalogram (EEG) assessment was also performed. EtOH significantly (
p
<0.001) induced psychomotor alterations (reduced locomotion, balance, coordination, muscle strength, and tolerance to cold), compared with control group rats. Pre-treatment with OFI extracts alleviated alterations and also inhibited elevation of blood ethanol levels. EEG (percent of total power for delta, theta, alpha, and beta) results for OFI group rats were similar to control rats, indicating a countering of EtOHinduced EEG changes. Extracts of OFI can be effective for alleviation of psychomotor alterations induced by EtOH administration.