Treatment of Lamivudine-Resistant Hepatitis B Infection in Post–Renal Transplant Patients With Adefovir Dipivoxil: Premiminary Results
We report the treatment outcome in six post–renal transplant patients with lamivudine-resistant hepatitis B virus (LR-HBV) infection using adefovir dipivoxil and followed for 6 to 18 months. Posttransplant immunosuppressive therapy was not altered. Adefovir dipivoxil effectively suppressed hepatitis...
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| Published in: | Transplantation proceedings Vol. 38; no. 9; pp. 3118 - 3120 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
01-11-2006
Elsevier Science |
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| Abstract | We report the treatment outcome in six post–renal transplant patients with lamivudine-resistant hepatitis B virus (LR-HBV) infection using adefovir dipivoxil and followed for 6 to 18 months. Posttransplant immunosuppressive therapy was not altered. Adefovir dipivoxil effectively suppressed hepatitis B virus DNA and improved alanine transferase, although DNA suppression seemed dependent on continued therapy. Nephrotoxicity led to withdrawal of the drug in three patients. This may limit therapeutic usefulness in a significant proportion of post–renal transplant patients with LR-HBV infection. |
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| AbstractList | We report the treatment outcome in six post–renal transplant patients with lamivudine-resistant hepatitis B virus (LR-HBV) infection using adefovir dipivoxil and followed for 6 to 18 months. Posttransplant immunosuppressive therapy was not altered. Adefovir dipivoxil effectively suppressed hepatitis B virus DNA and improved alanine transferase, although DNA suppression seemed dependent on continued therapy. Nephrotoxicity led to withdrawal of the drug in three patients. This may limit therapeutic usefulness in a significant proportion of post–renal transplant patients with LR-HBV infection. |
| Author | Manamperi, A. Dassanayake, A.S. de Silva, A.P. de Silva, H.J. |
| Author_xml | – sequence: 1 givenname: H.J. surname: de Silva fullname: de Silva, H.J. email: hjdes@sltnet.lk – sequence: 2 givenname: A.S. surname: Dassanayake fullname: Dassanayake, A.S. – sequence: 3 givenname: A. surname: Manamperi fullname: Manamperi, A. – sequence: 4 givenname: A.P. surname: de Silva fullname: de Silva, A.P. |
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| Cites_doi | 10.1097/00007890-200208270-00001 10.1111/j.1478-3231.2005.01171.x 10.1097/01.TP.0000116448.97841.6D 10.1053/j.gastro.2003.10.050 10.1053/j.gastro.2003.10.051 10.1016/j.transproceed.2005.02.010 10.1517/14656566.5.11.2361 |
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| Keywords | Antiretroviral agent RNA-directed DNA polymerase Hepatic disease Transplantation Homotransplantation Kidney Result Viral hepatitis B Surgery Reverse transcriptase inhibitor Nucleoside analog Antiviral Graft Pyrimidine nucleoside Human Postoperative Purine nucleotide Acyclic nucleotide Enzyme Transferases Enzyme inhibitor Lamivudine Patient Organic phosphonate Infection Medicine Resistance Nucleotidyltransferases Adefovir Treatment Urinary system Dideoxynucleoside Viral disease Digestive diseases |
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| References | Fabrizi, Dulai, Dixit (bib3) 2004; 77 Schiff, Lai, Hadziyannis (bib5) 2003; 38 Perrillo, Hann, Mutimer (bib7) 2004; 126 Yuen, Lai (bib6) 2004; 5 Gane, Pilmore (bib2) 2002; 74 Fabrizi, Lunghi, Poordad (bib1) 2002; 15 De Silva, Herath, Sheriff (bib4) 2005; 25 Peters, Hann, Martin (bib8) 2004; 126 Garcia, Mazuecos, Gonzalez (bib9) 2005; 37 Garcia (10.1016/j.transproceed.2006.08.186_bib9) 2005; 37 Yuen (10.1016/j.transproceed.2006.08.186_bib6) 2004; 5 Perrillo (10.1016/j.transproceed.2006.08.186_bib7) 2004; 126 Peters (10.1016/j.transproceed.2006.08.186_bib8) 2004; 126 Fabrizi (10.1016/j.transproceed.2006.08.186_bib3) 2004; 77 Fabrizi (10.1016/j.transproceed.2006.08.186_bib1) 2002; 15 De Silva (10.1016/j.transproceed.2006.08.186_bib4) 2005; 25 Gane (10.1016/j.transproceed.2006.08.186_bib2) 2002; 74 Schiff (10.1016/j.transproceed.2006.08.186_bib5) 2003; 38 |
| References_xml | – volume: 74 start-page: 427 year: 2002 ident: bib2 article-title: Management of chronic viral hepatitis before and after renal transplantation publication-title: Transplantation contributor: fullname: Pilmore – volume: 126 start-page: 343 year: 2004 ident: bib7 article-title: Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus publication-title: Gastroenterology contributor: fullname: Mutimer – volume: 126 start-page: 91 year: 2004 ident: bib8 article-title: Adefovir dipivixil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B publication-title: Gastroenterology contributor: fullname: Martin – volume: 25 start-page: 1074 year: 2005 ident: bib4 article-title: Lamivudine therapy for hepatitis B infection in post-renal transplant patients: results after 36 months follow-up publication-title: Liver Int contributor: fullname: Sheriff – volume: 38 start-page: 1419 year: 2003 ident: bib5 article-title: Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation ptients publication-title: Hepatology contributor: fullname: Hadziyannis – volume: 5 start-page: 2361 year: 2004 ident: bib6 article-title: Adefovir dipivoxil in chronic hepatitis B infection publication-title: Expert Opin Pharmacother contributor: fullname: Lai – volume: 15 start-page: 113 year: 2002 ident: bib1 article-title: Management of Hepatitis B after renal transplantation: an update publication-title: J Nephrol contributor: fullname: Poordad – volume: 37 start-page: 1462 year: 2005 ident: bib9 article-title: Treatment with adefovir dipivoxil in a renal transplant patient with renal insufficiency and lamivudine-resistant hepatitis B infection publication-title: Tansplant Proc contributor: fullname: Gonzalez – volume: 77 start-page: 859 year: 2004 ident: bib3 article-title: Lamivudine for the treatment of hepatitis B-related liver disease after renal transplantation: meta-analysis of clinical trials publication-title: Trnaplantation contributor: fullname: Dixit – volume: 74 start-page: 427 year: 2002 ident: 10.1016/j.transproceed.2006.08.186_bib2 article-title: Management of chronic viral hepatitis before and after renal transplantation publication-title: Transplantation doi: 10.1097/00007890-200208270-00001 contributor: fullname: Gane – volume: 25 start-page: 1074 year: 2005 ident: 10.1016/j.transproceed.2006.08.186_bib4 article-title: Lamivudine therapy for hepatitis B infection in post-renal transplant patients: results after 36 months follow-up publication-title: Liver Int doi: 10.1111/j.1478-3231.2005.01171.x contributor: fullname: De Silva – volume: 77 start-page: 859 year: 2004 ident: 10.1016/j.transproceed.2006.08.186_bib3 article-title: Lamivudine for the treatment of hepatitis B-related liver disease after renal transplantation: meta-analysis of clinical trials publication-title: Trnaplantation doi: 10.1097/01.TP.0000116448.97841.6D contributor: fullname: Fabrizi – volume: 126 start-page: 343 year: 2004 ident: 10.1016/j.transproceed.2006.08.186_bib7 article-title: Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus publication-title: Gastroenterology doi: 10.1053/j.gastro.2003.10.050 contributor: fullname: Perrillo – volume: 15 start-page: 113 year: 2002 ident: 10.1016/j.transproceed.2006.08.186_bib1 article-title: Management of Hepatitis B after renal transplantation: an update publication-title: J Nephrol contributor: fullname: Fabrizi – volume: 126 start-page: 91 year: 2004 ident: 10.1016/j.transproceed.2006.08.186_bib8 article-title: Adefovir dipivixil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B publication-title: Gastroenterology doi: 10.1053/j.gastro.2003.10.051 contributor: fullname: Peters – volume: 38 start-page: 1419 year: 2003 ident: 10.1016/j.transproceed.2006.08.186_bib5 article-title: Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation ptients publication-title: Hepatology contributor: fullname: Schiff – volume: 37 start-page: 1462 year: 2005 ident: 10.1016/j.transproceed.2006.08.186_bib9 article-title: Treatment with adefovir dipivoxil in a renal transplant patient with renal insufficiency and lamivudine-resistant hepatitis B infection publication-title: Tansplant Proc doi: 10.1016/j.transproceed.2005.02.010 contributor: fullname: Garcia – volume: 5 start-page: 2361 year: 2004 ident: 10.1016/j.transproceed.2006.08.186_bib6 article-title: Adefovir dipivoxil in chronic hepatitis B infection publication-title: Expert Opin Pharmacother doi: 10.1517/14656566.5.11.2361 contributor: fullname: Yuen |
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| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Medical sciences Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| Title | Treatment of Lamivudine-Resistant Hepatitis B Infection in Post–Renal Transplant Patients With Adefovir Dipivoxil: Premiminary Results |
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