The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

• Published in: Surgical endoscopy Vol. 17; no. 5; pp. 754 - 757
• Main Authors: KIRMAN, I, CEKIC, V, POLTARATSKAIA, N, ASI, Z, CONTE, S, FEINGOLD, D, FORDE, K. A, HUANG, E. H, WHELAN, R. L
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01-05-2003; Springer Nature B.V
• Subjects: Adolescent; Biological and medical sciences; CD3 Complex - biosynthesis; Colon - blood supply; Colorectal Neoplasms - blood supply; Colorectal Neoplasms - surgery; Female; Flow Cytometry - methods; Humans; Laparoscopy - methods; Lymphocyte Count - methods; Male; Medical sciences; Microcirculation; Miscellaneous; Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis; Rectum - blood supply; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; T-Lymphocytes - metabolism; Human; CD31; Endoscopic surgery; Immunology; Immune function; T-Lymphocyte; Laparoscopy; Biological effect; Laparotomy; T cells; Comparative study; Quantitative analysis
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-002-8942-3

Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+CD31+ cells.
Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies.
In the OS group, the percentage of CD3+CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+CD31+ cells and the length of incision in OS patients.
The percentage of CD3+CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.