A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems

2-Chloro-9-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)adenine (Cl-F-ara-A, clofarabine), a purine nucleoside analog with structural similarity to 2-chloro-2'-deoxyadenosine (Cl-dAdo, cladribine) and 9-beta-d-arabinofuranosyl-2-fluoroadenine (F-ara-A, fludarabine), has activity in adu...

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Bibliographic Details
Published in:	Molecular pharmacology Vol. 69; no. 1; p. 346
Main Authors:	King, Karen M, Damaraju, Vijaya L, Vickers, Mark F, Yao, Sylvia Y, Lang, Thach, Tackaberry, Tracey E, Mowles, Delores A, Ng, Amy M L, Young, James D, Cass, Carol E
Format:	Journal Article
Language:	English
Published:	United States 01-01-2006
Subjects:	Adenine Nucleotides Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Arabinonucleosides - metabolism Arabinonucleosides - pharmacology Biological Transport Cell Line Cladribine - metabolism Cladribine - pharmacology Humans Membrane Transport Proteins - metabolism Recombinant Proteins - metabolism Vidarabine - analogs & derivatives Vidarabine - metabolism Vidarabine - pharmacology Xenopus laevis
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