A Short Intramolecular Diels−Alder Route to Himbacine Derivatives

The intramolecular cycloaddition of 5 yields the unsaturated lactones 17a, 17b, and 17c as three major isomeric adducts. These were further reduced to the corresponding derivatives 21a, 21b, and 21c, which are intermediates for the synthesis of (+)‐himbacine and stereoisomers thereof. Precursor 5 wa...

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Bibliographic Details

Published in:	European journal of organic chemistry Vol. 2001; no. 15; pp. 2851 - 2860
Main Authors:	Hofman, Sven, Gao, Ling-Jie, Van Dingenen, Hilde, Hosten, Noël G. C., Van Haver, Dirk, De Clercq, Pierre J., Milanesio, Marco, Viterbo, Davide
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag GmbH 01-08-2001 WILEY‐VCH Verlag GmbH
Subjects:	Cycloadditions Neurotransmitters Receptors Total synthesis
Online Access:	Get full text
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