Investigation of the antileishmanial activity and mechanisms of action of acetyl-thiohydantoins

The currently available treatment options for leishmaniasis are associated with high costs, severe side effects, and high toxicity. In previous studies, thiohydantoins demonstrated some pharmacological activities and were shown to be potential hit compounds with antileishmanial properties. The prese...

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Bibliographic Details
Published in:	Chemico-biological interactions Vol. 351; p. 109690
Main Authors:	Bortoleti, Bruna Taciane da Silva, Gonçalves, Manoela Daiele, Tomiotto-Pellissier, Fernanda, Camargo, Priscila Goes, Assolini, João Paulo, Concato, Virginia Marcia, Detoni, Mariana Barbosa, Bidóia, Danielle Larazin, Bispo, Marcelle de Lima Ferreira, Lima, Camilo Henrique da Silva, de Macedo, Fernando Cesar, Conchon-Costa, Ivete, Miranda-Sapla, Milena Menegazzo, Wowk, Pryscilla Fanini, Pavanelli, Wander Rogério
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 05-01-2022
Subjects:	ADAM17 Protein - metabolism Animals Apoptosis-like Arginase - metabolism G2 Phase Cell Cycle Checkpoints - drug effects Heterocyclic Humans L. amazonensis Leishmania - drug effects Leishmania - enzymology Mice Mitochondria - drug effects Molecular docking Molecular Docking Simulation Protozoan Proteins - metabolism Sheep Thiohydantoins Thiohydantoins - chemical synthesis Thiohydantoins - metabolism Thiohydantoins - pharmacology Thiohydantoins - toxicity Trypanocidal Agents - chemical synthesis Trypanocidal Agents - metabolism Trypanocidal Agents - pharmacology Trypanocidal Agents - toxicity Tumor Necrosis Factor-alpha - metabolism Apoptosis-like Heterocyclic Molecular docking Thiohydantoins L. amazonensis
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