Transcriptome Analysis Reveals Molecular Mechanisms Underlying Methyl Jasmonate-mediated Biosynthesis of Protopanaxadiol-type Saponins in Panax notoginseng Leaves
Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notog...
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| Published in: | Journal of plant biology = Singmul Hakhoe chi Vol. 65; no. 1; pp. 29 - 41 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer Singapore
01-02-2022
Springer Nature B.V 한국식물학회 |
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| Abstract | Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins,
Panax notoginseng
leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in
P. notoginseng
leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in
P. notoginseng
leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in
P. notoginseng
leaves may be related to the high expression of
FPS, SS
,
SE
,
DS
and
UGTs
, and the low expression of
CYP716A53v2
and
β-AS
. The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in
P. notoginseng
leaves. |
|---|---|
| AbstractList | Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notoginseng leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in P. notoginseng leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in P. notoginseng leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in P. notoginseng leaves may be related to the high expression of FPS, SS, SE, DS and UGTs, and the low expression of CYP716A53v2 and β-AS. The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in P. notoginseng leaves. KCI Citation Count: 3 Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notoginseng leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in P. notoginseng leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in P. notoginseng leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in P. notoginseng leaves may be related to the high expression of FPS, SS, SE, DS and UGTs, and the low expression of CYP716A53v2 and β-AS. The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in P. notoginseng leaves. Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notoginseng leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in P. notoginseng leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in P. notoginseng leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in P. notoginseng leaves may be related to the high expression of FPS, SS , SE , DS and UGTs , and the low expression of CYP716A53v2 and β-AS . The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in P. notoginseng leaves. |
| Author | Tang, Junrong Jia, Bing Yang, Shengchao Yang, Jianli Shi, Huineng Zhang, Guanghui Fan, Wei Lin, Yuan Xu, Rui Li, Ying Tang, Qingyan Chen, Geng Li, Xuejiao |
| Author_xml | – sequence: 1 givenname: Ying surname: Li fullname: Li, Ying organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, College of Agriculture and Biotechnology, Yunnan Agricultural University – sequence: 2 givenname: Yuan surname: Lin fullname: Lin, Yuan organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, College of Agriculture and Biotechnology, Yunnan Agricultural University – sequence: 3 givenname: Bing surname: Jia fullname: Jia, Bing organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 4 givenname: Geng surname: Chen fullname: Chen, Geng organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, College of Agriculture and Biotechnology, Yunnan Agricultural University – sequence: 5 givenname: Huineng surname: Shi fullname: Shi, Huineng organization: College of Resources and Environment, Yunnan Agricultural University – sequence: 6 givenname: Rui surname: Xu fullname: Xu, Rui organization: College of Resources and Environment, Yunnan Agricultural University – sequence: 7 givenname: Xuejiao surname: Li fullname: Li, Xuejiao organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 8 givenname: Junrong surname: Tang fullname: Tang, Junrong organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 9 givenname: Qingyan surname: Tang fullname: Tang, Qingyan organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 10 givenname: Guanghui surname: Zhang fullname: Zhang, Guanghui organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 11 givenname: Jianli surname: Yang fullname: Yang, Jianli organization: State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University – sequence: 12 givenname: Wei surname: Fan fullname: Fan, Wei email: fanwei1128@aliyun.com organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University – sequence: 13 givenname: Shengchao orcidid: 0000-0002-4362-6578 surname: Yang fullname: Yang, Shengchao email: shengchaoyang@163.com organization: State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University |
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| CitedBy_id | crossref_primary_10_1016_j_indcrop_2022_115511 crossref_primary_10_1038_s41467_024_44854_7 crossref_primary_10_1177_1934578X231191886 crossref_primary_10_1093_hr_uhae058 crossref_primary_10_1007_s00425_023_04143_x crossref_primary_10_3390_genes13050823 |
| Cites_doi | 10.1111/bph.12660 10.3390/ijms20081843 10.1016/j.apsb.2017.12.010 10.1105/tpc.106.048017 10.1007/s13580-017-0041-4 10.1071/FP18106 10.1007/s11240-009-9535-9 10.1016/j.ejphar.2010.03.035 10.1016/j.ymben.2020.05.007 10.1007/s00253-015-6651-9 10.1556/018.69.2018.4.6 10.1007/s00253-004-1759-3 10.3389/fpls.2015.00952 10.1002/(SICI)1097-0290(19990105)62:1<97::AID-BIT11>3.0.CO;2-C 10.1073/pnas.90.24.11628 10.1093/pcp/pcs106 10.1007/s11240-018-01538-7 10.1016/j.biotechadv.2015.03.001 10.1007/s00299-013-1538-7 10.1155/2014/204840 10.1007/s11738-011-0844-3 10.1007/s13580-018-0103-2 10.1248/bpb.20.292 10.1016/S1369-703X(02)00029-3 10.3390/molecules23030589 10.1016/j.foodchem.2018.02.054 10.1016/j.indcrop.2020.112882 10.1038/nbt.1883 10.1007/s10725-014-0004-z 10.7324/JAPS.2016.60828 10.5142/jgr.2012.36.1.1 10.1016/j.procbio.2007.10.010 10.3390/ijms21041446 10.1111/nph.14638 10.1111/j.1365-313X.2011.04575.x 10.1046/j.1432-1327.1998.2560238.x 10.1007/s11434-015-0813-0 10.1016/S1360-1385(02)02250-1 10.1007/s00253-004-1831-z 10.3390/ijms20061310 10.1016/j.jpba.2006.01.058 10.1002/bit.20321 10.1038/s41421-018-0075-5 10.1007/s11103-018-0730-0 10.1093/pcp/pch126 10.1093/pcp/pcu147 10.1038/nmeth.1226 10.1016/j.jep.2016.05.005 10.1002/bab.1580 10.1111/nph.14910 10.1111/pbi.12214 |
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| Keywords | Biosynthesis Protopanaxadiol-type saponins Gene expression Methyl jasmonate Jasmonic acid signaling pathway |
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| References | Kim, Bang, Kim (CR17) 2009; 98 Ketchum, Gibson, Croteau, Shuler (CR13) 1999; 62 Wang, Gao, Zhang, Zuo, Zhang, Huang (CR34) 2012; 34 Corey, Matsuda, Bartel (CR5) 1993; 90 Grabherr, Haas, Yassour, Levin, Thompson, Amit (CR8) 2011; 29 Lee, Jeong, Seo, Shin, Kim, In (CR22) 2004; 45 Wang, Wang, Shi, Li, Fan, Huang, Li, Chen, Huang, Dai (CR39) 2020; 61 Jung, Kim, Park, Jeong, Park, Lim (CR12) 2014; 55 Biswas, Mathur, Gupta, Singh, Mathur (CR3) 2019; 136 Yu, Gao, Hahn, Paek (CR46) 2002; 11 Kushiro, Ohno, Shibuya, Ebizuka (CR20) 1997; 20 Wan, Yang, Li, Wang, Cui (CR31) 2006; 41 Zhao, Guo, Sun, Li, Liu, Wang (CR50) 2020; 157 Yang, Xiong, Wang, Wang (CR44) 2014; 2014 Mortazavi, Williams (CR24) 2008; 5 Tung, Hai (CR29) 2016; 6 Hu, Zhong (CR10) 2008; 43 Um, Lee, Kim, Jeong, Kim, Choi (CR30) 2017; 58 Cui, Mao, Chen, Guo (CR6) 2019; 20 Kim (CR16) 2012; 36 Wang, Wei, Ye, Li, Zhao, Yang (CR38) 2019; 5 Yang, Hu, Zhang, Gu, Gong, Zhu (CR45) 2018; 23 Weber (CR41) 2002; 7 Shi, Liu, Wei, Chan (CR27) 2018; 97 Han, Hwang, Choi, Kim, Choi (CR9) 2012; 53 Patra, Pattanaik, Schluttenhofer, Yuan (CR25) 2018; 217 Dombrecht, Xue, Sprague, Kirkegaard, Ross, Reid (CR7) 2007; 19 Zhao, Wang, Liu, Liang, Sun, Wu (CR49) 2014; 33 Major, Yoshida, Campos, Kapali, Xin, Sugimoto (CR23) 2017; 215 Wang, Zhang, Zhong (CR32) 2005; 67 Yu, Zhang, Zhang, Zhang, Lang, Zhang (CR47) 2019; 46 Zhou, Yang, Zhu, He, Zhang, Yu (CR51) 2015; 99 Bentebibel, Moyano, Palazon, Cusido, Bonfill, Eibl (CR2) 2005; 89 Wang, Yu, Qu, Xu, Han, Sui (CR33) 2010; 636 Zhang, Hedhili, Montiel, Zhang, Chatel, Pré (CR48) 2011; 67 Kim, Zhang, Yang (CR18) 2015; 33 Wang, Wang, Qi, Lu (CR37) 2018; 65 Chen, Li, Tan, Chen, Xiao, Ma (CR4) 2015; 6 Kushiro, Shibuya, Ebizuka (CR21) 1998; 256 Thanh, Murthy, Yu, Hahn, Paek (CR28) 2005; 67 Xiang, Zhu, Zhao, Zhang, Liu, Chen (CR43) 2015; 75 Afrin, Huang, Luo (CR1) 2015; 60 Khezerluo, Hosseini, Amiri (CR14) 2018; 69 Wei, Dong, Yang, Zhang, Xu, Yang (CR42) 2018; 8 Wang, Dong, Liu, Lau, Gao, Zhou (CR35) 2014; 171 Wang, Guo, Zhou (CR36) 2016; 188 Kochan, Balcerczak, Szymczyk, Sienkiewicz, Zielińska-Bliźniewska, Szymańska (CR19) 2019; 20 Sabater-Jara, Onrubia, Moyano, Bonfill, Palazón, Pedreño (CR26) 2014; 12 Kikowska, Kowalczyk, Stochmal, Thiem (CR15) 2019; 60 Jiao, Gu (CR11) 2018; 292 Wang, Song, Gong, Xu, Li (CR40) 2020; 21 MH Lee (9331_CR22) 2004; 45 B Dombrecht (9331_CR7) 2007; 19 E Kochan (9331_CR19) 2019; 20 MG Grabherr (9331_CR8) 2011; 29 D Kim (9331_CR16) 2012; 36 RE Ketchum (9331_CR13) 1999; 62 H Zhang (9331_CR48) 2011; 67 S Afrin (9331_CR1) 2015; 60 J Wang (9331_CR40) 2020; 21 SC Jung (9331_CR12) 2014; 55 B Tung (9331_CR29) 2016; 6 J Yang (9331_CR45) 2018; 23 X Yu (9331_CR47) 2019; 46 B Patra (9331_CR25) 2018; 217 H Shi (9331_CR27) 2018; 97 G Wei (9331_CR42) 2018; 8 EJ Corey (9331_CR5) 1993; 90 L Xiang (9331_CR43) 2015; 75 T Wang (9331_CR33) 2010; 636 T Wang (9331_CR36) 2016; 188 S Bentebibel (9331_CR2) 2005; 89 Y Um (9331_CR30) 2017; 58 OT Kim (9331_CR17) 2009; 98 A Mortazavi (9331_CR24) 2008; 5 Y Wang (9331_CR35) 2014; 171 A Sabater-Jara (9331_CR26) 2014; 12 C Jiao (9331_CR11) 2018; 292 P Wang (9331_CR38) 2019; 5 P Zhou (9331_CR51) 2015; 99 R Chen (9331_CR4) 2015; 6 KW Yu (9331_CR46) 2002; 11 NT Thanh (9331_CR28) 2005; 67 T Kushiro (9331_CR20) 1997; 20 T Biswas (9331_CR3) 2019; 136 T Kushiro (9331_CR21) 1998; 256 S Zhao (9331_CR49) 2014; 33 Y Zhao (9331_CR50) 2020; 157 F Hu (9331_CR10) 2008; 43 M Khezerluo (9331_CR14) 2018; 69 W Wang (9331_CR32) 2005; 67 Y Cui (9331_CR6) 2019; 20 M Kikowska (9331_CR15) 2019; 60 J Wang (9331_CR34) 2012; 34 H Weber (9331_CR41) 2002; 7 X Yang (9331_CR44) 2014; 2014 JB Wan (9331_CR31) 2006; 41 D Wang (9331_CR39) 2020; 61 J Han (9331_CR9) 2012; 53 Y Kim (9331_CR18) 2015; 33 IT Major (9331_CR23) 2017; 215 N Wang (9331_CR37) 2018; 65 |
| References_xml | – volume: 171 start-page: 3171 issue: 13 year: 2014 end-page: 3181 ident: CR35 article-title: Ginsenoside Rb3 attenuates oxidative stress and preserve endothelial function in renal arteries from hypertensive rats publication-title: Br J Pharmacol doi: 10.1111/bph.12660 contributor: fullname: Zhou – volume: 20 start-page: 1843 issue: 8 year: 2019 ident: CR6 article-title: Regulation mechanism of MYC family transcription factors in jasmonic acid signalling pathway on taxol biosynthesis publication-title: Int J Mol Sci doi: 10.3390/ijms20081843 contributor: fullname: Guo – volume: 8 start-page: 458 issue: 3 year: 2018 end-page: 465 ident: CR42 article-title: Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2017.12.010 contributor: fullname: Yang – volume: 19 start-page: 2225 issue: 7 year: 2007 end-page: 2245 ident: CR7 article-title: MYC2 differentially modulates diverse jasmonate-dependent functions in publication-title: Plant Cell doi: 10.1105/tpc.106.048017 contributor: fullname: Reid – volume: 58 start-page: 376 issue: 4 year: 2017 end-page: 383 ident: CR30 article-title: Expression analysis of ginsenoside biosynthesis-related genes in methyl jasmonate-treated adventitious roots of via DNA microarray analysis publication-title: Hortic Environ Biotechnol doi: 10.1007/s13580-017-0041-4 contributor: fullname: Choi – volume: 46 start-page: 197 issue: 3 year: 2019 end-page: 212 ident: CR47 article-title: The roles of methyl jasmonate to stress in plants publication-title: Funct Plant Biol doi: 10.1071/FP18106 contributor: fullname: Zhang – volume: 98 start-page: 25 issue: 1 year: 2009 end-page: 33 ident: CR17 article-title: Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate publication-title: Plant Cell Tissue Organ Cultn doi: 10.1007/s11240-009-9535-9 contributor: fullname: Kim – volume: 636 start-page: 121 issue: 1–3 year: 2010 end-page: 125 ident: CR33 article-title: Effects of ginsenoside Rb3 on myocardial and heart function impairment induced by isoproterenol in rats publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2010.03.035 contributor: fullname: Sui – volume: 61 start-page: 131 year: 2020 end-page: 140 ident: CR39 article-title: Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of using a synthetic biology platform publication-title: Metab Eng doi: 10.1016/j.ymben.2020.05.007 contributor: fullname: Dai – volume: 99 start-page: 7035 issue: 17 year: 2015 end-page: 7045 ident: CR51 article-title: Effects of β-cyclodextrin and methyl jasmonate on the production of vindoline, catharanthine, and ajmalicine in cambial meristematic cell cultures publication-title: Appl Microbiol Biot doi: 10.1007/s00253-015-6651-9 contributor: fullname: Yu – volume: 69 start-page: 437 issue: 4 year: 2018 end-page: 448 ident: CR14 article-title: Sodium nitroprusside stimulated production of tropane alkaloids and antioxidant enzymes activity in hairy root culture of L publication-title: Acta Biol Hung doi: 10.1556/018.69.2018.4.6 contributor: fullname: Amiri – volume: 67 start-page: 197 issue: 2 year: 2005 end-page: 201 ident: CR28 article-title: Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of in 5-l balloon type bubble bioreactors publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-004-1759-3 contributor: fullname: Paek – volume: 6 start-page: 952 year: 2015 ident: CR4 article-title: Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited hairy root cultures publication-title: Front Plant Sci doi: 10.3389/fpls.2015.00952 contributor: fullname: Ma – volume: 62 start-page: 97 issue: 1 year: 1999 end-page: 105 ident: CR13 article-title: The kinetics of taxoid accumulation in cell suspension cultures of following elicitation with methyl jasmonate publication-title: Biotechnol Bioeng doi: 10.1002/(SICI)1097-0290(19990105)62:1<97::AID-BIT11>3.0.CO;2-C contributor: fullname: Shuler – volume: 90 start-page: 11628 issue: 24 year: 1993 end-page: 11632 ident: CR5 article-title: Isolation of an gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen publication-title: PNAS doi: 10.1073/pnas.90.24.11628 contributor: fullname: Bartel – volume: 53 start-page: 1535 issue: 9 year: 2012 end-page: 1545 ident: CR9 article-title: Cytochrome P450 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcs106 contributor: fullname: Choi – volume: 136 start-page: 575 issue: 3 year: 2019 end-page: 588 ident: CR3 article-title: Salicylic acid and ultrasonic stress modulated gene expression and ginsenoside production in differentially affected (L.) and (Ban.) cell suspensions publication-title: Plant Cell Tissue Organ Cult doi: 10.1007/s11240-018-01538-7 contributor: fullname: Mathur – volume: 33 start-page: 717 issue: 6 year: 2015 end-page: 735 ident: CR18 article-title: Biosynthesis and biotechnological production of ginsenosides publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2015.03.001 contributor: fullname: Yang – volume: 33 start-page: 393 issue: 3 year: 2014 end-page: 400 ident: CR49 article-title: Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis publication-title: Plant Cell Rep doi: 10.1007/s00299-013-1538-7 contributor: fullname: Wu – volume: 2014 start-page: 1 year: 2014 end-page: 13 ident: CR44 article-title: Protective effects of saponins on cardiovascular diseases: a comprehensive overview of experimental studies publication-title: Evid Based Complement Altern doi: 10.1155/2014/204840 contributor: fullname: Wang – volume: 34 start-page: 397 issue: 2 year: 2012 end-page: 403 ident: CR34 article-title: Advances in study of ginsenoside biosynthesis pathway in C. A. Meyer publication-title: Acta Physiol Plant doi: 10.1007/s11738-011-0844-3 contributor: fullname: Huang – volume: 60 start-page: 147 issue: 1 year: 2019 end-page: 154 ident: CR15 article-title: Enhanced accumulation of triterpenoid saponins in in vitro plantlets and dedifferentiated cultures of L.: a medicinal plant publication-title: Hortic Environ Biotechnol doi: 10.1007/s13580-018-0103-2 contributor: fullname: Thiem – volume: 20 start-page: 292 issue: 3 year: 1997 end-page: 294 ident: CR20 article-title: In vitro conversion of 2,3-oxidosqualene into dammarenediol by microsomes publication-title: Biol Pharm Bull doi: 10.1248/bpb.20.292 contributor: fullname: Ebizuka – volume: 11 start-page: 211 issue: 2–3 year: 2002 end-page: 215 ident: CR46 article-title: Jasmonic acid improves ginsenoside accumulation in adventitious root culture of Panax ginseng C.A. Meyer publication-title: Biochem Eng J doi: 10.1016/S1369-703X(02)00029-3 contributor: fullname: Paek – volume: 23 start-page: 589 issue: 3 year: 2018 ident: CR45 article-title: Progress on the studies of the key enzymes of ginsenoside biosynthesis publication-title: Molecules doi: 10.3390/molecules23030589 contributor: fullname: Zhu – volume: 292 start-page: 372 year: 2018 end-page: 376 ident: CR11 article-title: iTRAQ-based proteomic analysis reveals changes in response to sodium nitroprusside treatment in soybean sprouts publication-title: Food Chem doi: 10.1016/j.foodchem.2018.02.054 contributor: fullname: Gu – volume: 157 start-page: 112882 year: 2020 ident: CR50 article-title: A culture system for the stable and high-efficiency proliferation of adventitious roots of and ginsenoside accumulation publication-title: Ind Crop Prod doi: 10.1016/j.indcrop.2020.112882 contributor: fullname: Wang – volume: 29 start-page: 644 issue: 7 year: 2011 end-page: 652 ident: CR8 article-title: Full-length transcriptome assembly from RNA-Seq data without a reference genome publication-title: Nat Biotechnol doi: 10.1038/nbt.1883 contributor: fullname: Amit – volume: 75 start-page: 435 issue: 2 year: 2015 end-page: 441 ident: CR43 article-title: Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in by exogenous MeJA treatment publication-title: Plant Growth Regul doi: 10.1007/s10725-014-0004-z contributor: fullname: Chen – volume: 6 start-page: 174 issue: 8 year: 2016 end-page: 178 ident: CR29 article-title: Phytochemical and pharmacology effect of publication-title: J Pharm Sci US doi: 10.7324/JAPS.2016.60828 contributor: fullname: Hai – volume: 36 start-page: 1 issue: 1 year: 2012 end-page: 15 ident: CR16 article-title: Chemical diversity of , , and publication-title: J Ginseng Res doi: 10.5142/jgr.2012.36.1.1 contributor: fullname: Kim – volume: 43 start-page: 113 issue: 1 year: 2008 end-page: 118 ident: CR10 article-title: Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of treated with chemically synthesized 2-hydroxyethyl jasmonate publication-title: Process Biochem doi: 10.1016/j.procbio.2007.10.010 contributor: fullname: Zhong – volume: 21 start-page: 1446 issue: 4 year: 2020 ident: CR40 article-title: Functions of jasmonic acid in plant regulation and response to abiotic stress publication-title: Int J Mol Sci doi: 10.3390/ijms21041446 contributor: fullname: Li – volume: 215 start-page: 1533 issue: 4 year: 2017 end-page: 1547 ident: CR23 article-title: Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module publication-title: New Phytol doi: 10.1111/nph.14638 contributor: fullname: Sugimoto – volume: 67 start-page: 61 issue: 1 year: 2011 end-page: 71 ident: CR48 article-title: The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in publication-title: Plant J doi: 10.1111/j.1365-313X.2011.04575.x contributor: fullname: Pré – volume: 256 start-page: 238 issue: 1 year: 1998 end-page: 244 ident: CR21 article-title: Beta-amyrin synthase-cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.1998.2560238.x contributor: fullname: Ebizuka – volume: 60 start-page: 1062 issue: 12 year: 2015 end-page: 1072 ident: CR1 article-title: JA-mediated transcriptional regulation of secondary metabolism in medicinal plants publication-title: Sci Bull doi: 10.1007/s11434-015-0813-0 contributor: fullname: Luo – volume: 7 start-page: 217 issue: 5 year: 2002 end-page: 224 ident: CR41 article-title: Fatty acid-derived signals in plants publication-title: Trends Plant Sci doi: 10.1016/S1360-1385(02)02250-1 contributor: fullname: Weber – volume: 67 start-page: 752 issue: 6 year: 2005 end-page: 758 ident: CR32 article-title: Enhancement of ginsenoside biosynthesis in high-density cultivation of cells by various strategies of methyl jasmonate elicitation publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-004-1831-z contributor: fullname: Zhong – volume: 20 start-page: 1310 issue: 6 year: 2019 ident: CR19 article-title: Abscisic acid regulates the 3-hydroxy-3-methylglutaryl CoA reductase gene promoter and ginsenoside production in hairy root cultures publication-title: Int J Mol Sci doi: 10.3390/ijms20061310 contributor: fullname: Szymańska – volume: 41 start-page: 1596 issue: 5 year: 2006 end-page: 1601 ident: CR31 article-title: Chemical characteristics for different parts of using pressurized liquid extraction and HPLC-ELSD publication-title: J Pharm Biomed doi: 10.1016/j.jpba.2006.01.058 contributor: fullname: Cui – volume: 89 start-page: 647 issue: 6 year: 2005 end-page: 655 ident: CR2 article-title: Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of publication-title: Biotechnol Bioeng doi: 10.1002/bit.20321 contributor: fullname: Eibl – volume: 5 start-page: 5 issue: 1 year: 2019 ident: CR38 article-title: Synthesizing ginsenoside Rh2 in cell factory at high-efficiency publication-title: Cell Discov doi: 10.1038/s41421-018-0075-5 contributor: fullname: Yang – volume: 97 start-page: 165 issue: 1–2 year: 2018 end-page: 176 ident: CR27 article-title: The zinc-finger transcription factor ZAT6 is essential for hydrogen peroxide induction of anthocyanin synthesis in publication-title: Plant Mol Biol doi: 10.1007/s11103-018-0730-0 contributor: fullname: Chan – volume: 45 start-page: 976 issue: 8 year: 2004 end-page: 984 ident: CR22 article-title: Enhanced triterpene and phytosterol biosynthesis in overexpressing squalene synthase gene publication-title: Plant Cell Physiol doi: 10.1093/pcp/pch126 contributor: fullname: In – volume: 55 start-page: 2177 issue: 12 year: 2014 end-page: 2188 ident: CR12 article-title: Two ginseng UDP glycosyltransferases synthesize ginsenoside Rg3 and Rd publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcu147 contributor: fullname: Lim – volume: 5 start-page: 621 issue: 7 year: 2008 end-page: 628 ident: CR24 article-title: Mapping and quantifying mammalian transcriptomes by RNA-Seq publication-title: Nat Methods doi: 10.1038/nmeth.1226 contributor: fullname: Williams – volume: 188 start-page: 234 year: 2016 end-page: 258 ident: CR36 article-title: Traditional uses, botany, phytochemistry, pharmacology and toxicology of (Burk.) F.H. Chen: a review publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2016.05.005 contributor: fullname: Zhou – volume: 65 start-page: 119 issue: 2 year: 2018 end-page: 127 ident: CR37 article-title: Construct a gene-to-metabolite network to screen the key genes of triterpene saponin biosynthetic pathway in publication-title: Biotechnol Appl Biochem doi: 10.1002/bab.1580 contributor: fullname: Lu – volume: 217 start-page: 1566 issue: 4 year: 2018 end-page: 1581 ident: CR25 article-title: A network of jasmonate-responsive bHLH factors modulate monoterpenoid indole alkaloid biosynthesis in publication-title: New Phytol doi: 10.1111/nph.14910 contributor: fullname: Yuan – volume: 12 start-page: 1075 issue: 8 year: 2014 end-page: 1084 ident: CR26 article-title: Synergistic effect of cyclodextrins and methyl jasmonate on taxane production in cell cultures publication-title: Plant Biotechnol J doi: 10.1111/pbi.12214 contributor: fullname: Pedreño – volume: 43 start-page: 113 issue: 1 year: 2008 ident: 9331_CR10 publication-title: Process Biochem doi: 10.1016/j.procbio.2007.10.010 contributor: fullname: F Hu – volume: 41 start-page: 1596 issue: 5 year: 2006 ident: 9331_CR31 publication-title: J Pharm Biomed doi: 10.1016/j.jpba.2006.01.058 contributor: fullname: JB Wan – volume: 215 start-page: 1533 issue: 4 year: 2017 ident: 9331_CR23 publication-title: New Phytol doi: 10.1111/nph.14638 contributor: fullname: IT Major – volume: 6 start-page: 174 issue: 8 year: 2016 ident: 9331_CR29 publication-title: J Pharm Sci US doi: 10.7324/JAPS.2016.60828 contributor: fullname: B Tung – volume: 12 start-page: 1075 issue: 8 year: 2014 ident: 9331_CR26 publication-title: Plant Biotechnol J doi: 10.1111/pbi.12214 contributor: fullname: A Sabater-Jara – volume: 217 start-page: 1566 issue: 4 year: 2018 ident: 9331_CR25 publication-title: New Phytol doi: 10.1111/nph.14910 contributor: fullname: B Patra – volume: 46 start-page: 197 issue: 3 year: 2019 ident: 9331_CR47 publication-title: Funct Plant Biol doi: 10.1071/FP18106 contributor: fullname: X Yu – volume: 636 start-page: 121 issue: 1–3 year: 2010 ident: 9331_CR33 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2010.03.035 contributor: fullname: T Wang – volume: 256 start-page: 238 issue: 1 year: 1998 ident: 9331_CR21 publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.1998.2560238.x contributor: fullname: T Kushiro – volume: 23 start-page: 589 issue: 3 year: 2018 ident: 9331_CR45 publication-title: Molecules doi: 10.3390/molecules23030589 contributor: fullname: J Yang – volume: 67 start-page: 61 issue: 1 year: 2011 ident: 9331_CR48 publication-title: Plant J doi: 10.1111/j.1365-313X.2011.04575.x contributor: fullname: H Zhang – volume: 171 start-page: 3171 issue: 13 year: 2014 ident: 9331_CR35 publication-title: Br J Pharmacol doi: 10.1111/bph.12660 contributor: fullname: Y Wang – volume: 99 start-page: 7035 issue: 17 year: 2015 ident: 9331_CR51 publication-title: Appl Microbiol Biot doi: 10.1007/s00253-015-6651-9 contributor: fullname: P Zhou – volume: 97 start-page: 165 issue: 1–2 year: 2018 ident: 9331_CR27 publication-title: Plant Mol Biol doi: 10.1007/s11103-018-0730-0 contributor: fullname: H Shi – volume: 19 start-page: 2225 issue: 7 year: 2007 ident: 9331_CR7 publication-title: Plant Cell doi: 10.1105/tpc.106.048017 contributor: fullname: B Dombrecht – volume: 136 start-page: 575 issue: 3 year: 2019 ident: 9331_CR3 publication-title: Plant Cell Tissue Organ Cult doi: 10.1007/s11240-018-01538-7 contributor: fullname: T Biswas – volume: 20 start-page: 1310 issue: 6 year: 2019 ident: 9331_CR19 publication-title: Int J Mol Sci doi: 10.3390/ijms20061310 contributor: fullname: E Kochan – volume: 8 start-page: 458 issue: 3 year: 2018 ident: 9331_CR42 publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2017.12.010 contributor: fullname: G Wei – volume: 45 start-page: 976 issue: 8 year: 2004 ident: 9331_CR22 publication-title: Plant Cell Physiol doi: 10.1093/pcp/pch126 contributor: fullname: MH Lee – volume: 34 start-page: 397 issue: 2 year: 2012 ident: 9331_CR34 publication-title: Acta Physiol Plant doi: 10.1007/s11738-011-0844-3 contributor: fullname: J Wang – volume: 53 start-page: 1535 issue: 9 year: 2012 ident: 9331_CR9 publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcs106 contributor: fullname: J Han – volume: 60 start-page: 147 issue: 1 year: 2019 ident: 9331_CR15 publication-title: Hortic Environ Biotechnol doi: 10.1007/s13580-018-0103-2 contributor: fullname: M Kikowska – volume: 67 start-page: 197 issue: 2 year: 2005 ident: 9331_CR28 publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-004-1759-3 contributor: fullname: NT Thanh – volume: 6 start-page: 952 year: 2015 ident: 9331_CR4 publication-title: Front Plant Sci doi: 10.3389/fpls.2015.00952 contributor: fullname: R Chen – volume: 2014 start-page: 1 year: 2014 ident: 9331_CR44 publication-title: Evid Based Complement Altern doi: 10.1155/2014/204840 contributor: fullname: X Yang – volume: 292 start-page: 372 year: 2018 ident: 9331_CR11 publication-title: Food Chem doi: 10.1016/j.foodchem.2018.02.054 contributor: fullname: C Jiao – volume: 58 start-page: 376 issue: 4 year: 2017 ident: 9331_CR30 publication-title: Hortic Environ Biotechnol doi: 10.1007/s13580-017-0041-4 contributor: fullname: Y Um – volume: 157 start-page: 112882 year: 2020 ident: 9331_CR50 publication-title: Ind Crop Prod doi: 10.1016/j.indcrop.2020.112882 contributor: fullname: Y Zhao – volume: 33 start-page: 393 issue: 3 year: 2014 ident: 9331_CR49 publication-title: Plant Cell Rep doi: 10.1007/s00299-013-1538-7 contributor: fullname: S Zhao – volume: 20 start-page: 1843 issue: 8 year: 2019 ident: 9331_CR6 publication-title: Int J Mol Sci doi: 10.3390/ijms20081843 contributor: fullname: Y Cui – volume: 62 start-page: 97 issue: 1 year: 1999 ident: 9331_CR13 publication-title: Biotechnol Bioeng doi: 10.1002/(SICI)1097-0290(19990105)62:1<97::AID-BIT11>3.0.CO;2-C contributor: fullname: RE Ketchum – volume: 89 start-page: 647 issue: 6 year: 2005 ident: 9331_CR2 publication-title: Biotechnol Bioeng doi: 10.1002/bit.20321 contributor: fullname: S Bentebibel – volume: 33 start-page: 717 issue: 6 year: 2015 ident: 9331_CR18 publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2015.03.001 contributor: fullname: Y Kim – volume: 188 start-page: 234 year: 2016 ident: 9331_CR36 publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2016.05.005 contributor: fullname: T Wang – volume: 11 start-page: 211 issue: 2–3 year: 2002 ident: 9331_CR46 publication-title: Biochem Eng J doi: 10.1016/S1369-703X(02)00029-3 contributor: fullname: KW Yu – volume: 98 start-page: 25 issue: 1 year: 2009 ident: 9331_CR17 publication-title: Plant Cell Tissue Organ Cultn doi: 10.1007/s11240-009-9535-9 contributor: fullname: OT Kim – volume: 75 start-page: 435 issue: 2 year: 2015 ident: 9331_CR43 publication-title: Plant Growth Regul doi: 10.1007/s10725-014-0004-z contributor: fullname: L Xiang – volume: 55 start-page: 2177 issue: 12 year: 2014 ident: 9331_CR12 publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcu147 contributor: fullname: SC Jung – volume: 5 start-page: 621 issue: 7 year: 2008 ident: 9331_CR24 publication-title: Nat Methods doi: 10.1038/nmeth.1226 contributor: fullname: A Mortazavi – volume: 90 start-page: 11628 issue: 24 year: 1993 ident: 9331_CR5 publication-title: PNAS doi: 10.1073/pnas.90.24.11628 contributor: fullname: EJ Corey – volume: 67 start-page: 752 issue: 6 year: 2005 ident: 9331_CR32 publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-004-1831-z contributor: fullname: W Wang – volume: 36 start-page: 1 issue: 1 year: 2012 ident: 9331_CR16 publication-title: J Ginseng Res doi: 10.5142/jgr.2012.36.1.1 contributor: fullname: D Kim – volume: 60 start-page: 1062 issue: 12 year: 2015 ident: 9331_CR1 publication-title: Sci Bull doi: 10.1007/s11434-015-0813-0 contributor: fullname: S Afrin – volume: 65 start-page: 119 issue: 2 year: 2018 ident: 9331_CR37 publication-title: Biotechnol Appl Biochem doi: 10.1002/bab.1580 contributor: fullname: N Wang – volume: 5 start-page: 5 issue: 1 year: 2019 ident: 9331_CR38 publication-title: Cell Discov doi: 10.1038/s41421-018-0075-5 contributor: fullname: P Wang – volume: 21 start-page: 1446 issue: 4 year: 2020 ident: 9331_CR40 publication-title: Int J Mol Sci doi: 10.3390/ijms21041446 contributor: fullname: J Wang – volume: 61 start-page: 131 year: 2020 ident: 9331_CR39 publication-title: Metab Eng doi: 10.1016/j.ymben.2020.05.007 contributor: fullname: D Wang – volume: 20 start-page: 292 issue: 3 year: 1997 ident: 9331_CR20 publication-title: Biol Pharm Bull doi: 10.1248/bpb.20.292 contributor: fullname: T Kushiro – volume: 69 start-page: 437 issue: 4 year: 2018 ident: 9331_CR14 publication-title: Acta Biol Hung doi: 10.1556/018.69.2018.4.6 contributor: fullname: M Khezerluo – volume: 7 start-page: 217 issue: 5 year: 2002 ident: 9331_CR41 publication-title: Trends Plant Sci doi: 10.1016/S1360-1385(02)02250-1 contributor: fullname: H Weber – volume: 29 start-page: 644 issue: 7 year: 2011 ident: 9331_CR8 publication-title: Nat Biotechnol doi: 10.1038/nbt.1883 contributor: fullname: MG Grabherr |
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| Snippet | Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However,... |
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| SubjectTerms | Biomedical and Life Sciences Biosynthesis Fatty acids Flavonoids Genes Herbal medicine High performance liquid chromatography Jasmonic acid Leaves Life Sciences Liquid chromatography Medicinal plants Metabolites Methyl jasmonate Molecular modelling Panax notoginseng Plant Breeding/Biotechnology Plant Ecology Plant Genetics and Genomics Plant Sciences Plant Systematics/Taxonomy/Biogeography Proteins Research Article Saponins Secondary metabolites Signal transduction Transcriptomes 생물학 |
| Title | Transcriptome Analysis Reveals Molecular Mechanisms Underlying Methyl Jasmonate-mediated Biosynthesis of Protopanaxadiol-type Saponins in Panax notoginseng Leaves |
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