Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate-nitromethane system

We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 49; no. 58; p. 6525
Main Authors:	Kim, Shokaku, Shoji, Takao, Kitano, Yoshikazu, Chiba, Kazuhiro
Format:	Journal Article
Language:	English
Published:	England 01-01-2013
Subjects:	Aza Compounds - chemistry Electrochemical Techniques Lithium Compounds - chemistry Methane - analogs & derivatives Methane - chemistry Nitroparaffins - chemistry Nucleosides - chemistry Perchlorates - chemistry Pyrrolidines - chemistry
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Description
Summary:	We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position.
ISSN:	1364-548X
DOI:	10.1039/c3cc43273d