Long noncoding RNA ANCR promotes migration, invasion, EMT progress and stemness of nasopharyngeal carcinoma cells via the miR-4731-5p/NMT1 axis
In our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal carcinoma (NPC) cells. However, the molecular mechanism and function of ANCR are not fully studied. The current study aimed to further investigate the ro...
Saved in:
| Published in: | Pathology, research and practice Vol. 224; p. 153540 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Germany
Elsevier GmbH
01-08-2021
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | In our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal carcinoma (NPC) cells. However, the molecular mechanism and function of ANCR are not fully studied. The current study aimed to further investigate the role and underlying molecular mechanism of ANCR in NPC.
RT-qPCR and western blot analyses were used to detect the levels of RNAs and proteins in NPC cells. Wound healing and Transwell assays were used to examine the migration and invasion of NPC cells. The relationship among ANCR, miR-4731-5p and N-myristoyltransferase 1 (NMT1) was investigated by RIP and luciferase reporter assays. The NPC cell stemness was accessed by the sphere formation assay.
ANCR was significantly highly expressed in NPC cell lines. Silenced ANCR suppressed cell migration, invasion epithelial-mesenchymal transition (EMT) process and cell stemness in NPC. Furthermore, ANCR sponged miR-4731-5p to upregulate the NMT1 expression. Rescue assays indicated that NMT1 neutralized the antioncogenic effect induced by silenced ANCR on NPC cells.
Long noncoding RNA ANCR suppresses malignant behaviors of nasopharyngeal carcinoma cells by regulating miR-4731-5p/NMT1 axis. |
|---|---|
| AbstractList | In our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal carcinoma (NPC) cells. However, the molecular mechanism and function of ANCR are not fully studied. The current study aimed to further investigate the role and underlying molecular mechanism of ANCR in NPC.
RT-qPCR and western blot analyses were used to detect the levels of RNAs and proteins in NPC cells. Wound healing and Transwell assays were used to examine the migration and invasion of NPC cells. The relationship among ANCR, miR-4731-5p and N-myristoyltransferase 1 (NMT1) was investigated by RIP and luciferase reporter assays. The NPC cell stemness was accessed by the sphere formation assay.
ANCR was significantly highly expressed in NPC cell lines. Silenced ANCR suppressed cell migration, invasion epithelial-mesenchymal transition (EMT) process and cell stemness in NPC. Furthermore, ANCR sponged miR-4731-5p to upregulate the NMT1 expression. Rescue assays indicated that NMT1 neutralized the antioncogenic effect induced by silenced ANCR on NPC cells.
Long noncoding RNA ANCR suppresses malignant behaviors of nasopharyngeal carcinoma cells by regulating miR-4731-5p/NMT1 axis. BACKGROUNDIn our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal carcinoma (NPC) cells. However, the molecular mechanism and function of ANCR are not fully studied. The current study aimed to further investigate the role and underlying molecular mechanism of ANCR in NPC. METHODSRT-qPCR and western blot analyses were used to detect the levels of RNAs and proteins in NPC cells. Wound healing and Transwell assays were used to examine the migration and invasion of NPC cells. The relationship among ANCR, miR-4731-5p and N-myristoyltransferase 1 (NMT1) was investigated by RIP and luciferase reporter assays. The NPC cell stemness was accessed by the sphere formation assay. RESULTSANCR was significantly highly expressed in NPC cell lines. Silenced ANCR suppressed cell migration, invasion epithelial-mesenchymal transition (EMT) process and cell stemness in NPC. Furthermore, ANCR sponged miR-4731-5p to upregulate the NMT1 expression. Rescue assays indicated that NMT1 neutralized the antioncogenic effect induced by silenced ANCR on NPC cells. CONCLUSIONSLong noncoding RNA ANCR suppresses malignant behaviors of nasopharyngeal carcinoma cells by regulating miR-4731-5p/NMT1 axis. |
| ArticleNumber | 153540 |
| Author | Liu, Jianyong Yuan, Yifang Ma, Xingkai Zhou, Jieyu Li, Menglin Yu, Yan Lu, Jianbin |
| Author_xml | – sequence: 1 givenname: Xingkai surname: Ma fullname: Ma, Xingkai organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 2 givenname: Yifang surname: Yuan fullname: Yuan, Yifang organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 3 givenname: Jianbin surname: Lu fullname: Lu, Jianbin organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 4 givenname: Menglin surname: Li fullname: Li, Menglin organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 5 givenname: Yan surname: Yu fullname: Yu, Yan organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 6 givenname: Jianyong surname: Liu fullname: Liu, Jianyong email: zjgljyys@163.com organization: Department of Otorhinolaryngology, Zhangjiagang First People’s Hospital, Affiliated Hospital of Soochow University, Suzhou 215600, Jiangsu, China – sequence: 7 givenname: Jieyu surname: Zhou fullname: Zhou, Jieyu email: entzhoujieyu@hotmail.com organization: Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34333213$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1uEzEUhS1URNPCA7BBXrJgUnuu7ZmKVRSVgpQGKQpry7FvUkcZe7AnUXkKXrkeUliyuj_67pGPzxW5CDEgIe85m3LG1c1-2qd-WrOaT7kEKdgrMuGKtxVTwC_IhIEQFQNoL8lVznvGWMMEf0MuQQBAzWFCfi9i2NGia6PzpVstZ3S2nK9on2IXB8y087tkBh_DJ-rDyeQ_3d3DeiR2CXOmJjiaB-zCOMQtDSbH_tGkX2GH5kCtSdaH2Blq8XDI9OQNHR6xCK8q0QCvZH-zfFhzap58fkteb80h47uXek1-fLlbz79Wi-_33-azRWVBwlBhc6scYuukgo2qBdsoibgRWyh7U9-CEVIptVGNMS2v0XGwTY1W1spZ10q4Jh_PusXFzyPmQXc-j-8zAeMx61rKRgpQDRSUn1GbYs4Jt7pPviv2NGd6zEHvy6bXYw76nEO5-fAif9x06P5d_P34Anw-A1hMnjwmna3HYNH5hHbQLvr_yD8DokyZ8Q |
| CitedBy_id | crossref_primary_10_1186_s12967_024_05246_z crossref_primary_10_1080_21655979_2022_2059960 crossref_primary_10_1139_cjpp_2021_0411 crossref_primary_10_3389_fcell_2021_753706 crossref_primary_10_1093_jrr_rrae042 crossref_primary_10_1515_med_2022_0515 |
| Cites_doi | 10.1007/s00018-016-2174-5 10.1016/j.cell.2011.07.014 10.1080/15476286.2019.1708547 10.1111/jcmm.14823 10.1038/s41419-018-1201-x 10.3233/CBM-161715 10.1098/rstb.2016.0270 10.1002/ijc.24293 10.1007/s10620-019-06019-1 10.1158/1055-9965.EPI-16-0149 10.1186/s13046-018-0918-9 10.1038/s41419-019-2060-9 10.1016/j.canlet.2016.01.040 10.1042/BSR20202127 10.1136/jmedgenet-2015-103334 10.1093/abbs/gmaa111 10.1152/physrev.00041.2015 10.1186/s12885-019-6335-4 10.1002/jcp.28547 10.1007/s11033-020-05932-3 10.1038/nature12986 10.2147/OTT.S182573 10.1158/0008-5472.CAN-19-0799 10.1002/cncr.30643 10.1016/S0140-6736(19)30956-0 10.3322/caac.21492 10.1002/jcp.29382 10.1158/0008-5472.CAN-17-0981 10.1016/j.omtn.2020.10.017 10.1038/s41388-020-01531-5 10.3389/fgene.2012.00219 |
| ContentType | Journal Article |
| Copyright | 2021 Elsevier GmbH Copyright © 2021 Elsevier GmbH. All rights reserved. |
| Copyright_xml | – notice: 2021 Elsevier GmbH – notice: Copyright © 2021 Elsevier GmbH. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.prp.2021.153540 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1618-0631 |
| EndPage | 153540 |
| ExternalDocumentID | 10_1016_j_prp_2021_153540 34333213 S0344033821002016 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 123 1B1 1~. 1~5 29O 3O- 3V. 4.4 457 4CK 4G. 53G 5RE 5VS 7-5 71M 7X7 88E 88I 8AF 8FE 8FH 8FI 8FJ 8G5 8P~ 8R4 8R5 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AAKPP AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABGSF ABLJU ABLVK ABMAC ABMZM ABUDA ABUWG ABXDB ABYKQ ACDAQ ACGFO ACGFS ACGOD ACPRK ACRLP ADBBV ADEZE ADKUU ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKRA AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AHMBA AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN AZQEC BBNVY BCR BCU BEC BENPR BHPHI BKOJK BLC BLXMC BNPGV BPHCQ BVXVI CAG CCPQU COF CS3 DOVZS DU5 DWQXO EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-Q GBLVA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ IHE J1W K-O KOM L7B LCYCR LK8 M1P M2O M2P M2Q M41 M7P MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PADUT PC. PEA PQQKQ PRG PROAC PSQYO Q2X Q38 R2- RIG ROL RPZ S0X SDF SDG SES SEW SJFOW SSH SSU SSZ T5I T5J T5K UDS UKHRP X7M YCJ ZA5 ZGI ZXP ~G- AAXKI AFJKZ AKRWK ALIPV CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c353t-e796dee8d563b6240b65eeb4f396da293a45666b67aa812ed13c72ec526dcd853 |
| ISSN | 0344-0338 |
| IngestDate | Fri Oct 25 02:16:52 EDT 2024 Thu Nov 21 22:26:30 EST 2024 Sat Sep 28 08:22:59 EDT 2024 Fri Feb 23 02:43:40 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Nasopharyngeal carcinoma NMT1 ANCR MiR-4731-5p |
| Language | English |
| License | Copyright © 2021 Elsevier GmbH. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c353t-e796dee8d563b6240b65eeb4f396da293a45666b67aa812ed13c72ec526dcd853 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 34333213 |
| PQID | 2557543673 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | proquest_miscellaneous_2557543673 crossref_primary_10_1016_j_prp_2021_153540 pubmed_primary_34333213 elsevier_sciencedirect_doi_10_1016_j_prp_2021_153540 |
| PublicationCentury | 2000 |
| PublicationDate | August 2021 2021-Aug 2021-08-00 20210801 |
| PublicationDateYYYYMMDD | 2021-08-01 |
| PublicationDate_xml | – month: 08 year: 2021 text: August 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | Germany |
| PublicationPlace_xml | – name: Germany |
| PublicationTitle | Pathology, research and practice |
| PublicationTitleAlternate | Pathol Res Pract |
| PublicationYear | 2021 |
| Publisher | Elsevier GmbH |
| Publisher_xml | – name: Elsevier GmbH |
| References | Liu, Chang, Liu, Cai, Zhang, Chen, Huang, Xie, Cao, Shao, Jia, Zheng, Liao, Chen, Lin, Liang, Ernberg, Vaughan, Adami, Huang, Zeng, Zeng, Ye (bib5) 2017; 123 Deng, Gao, Liu, He, Xu, Qiang, Wu, Liu (bib30) 2018; 9 Tang, Chen, Xue, He, Zheng, Zeng, Jia (bib2) 2016; 374 Kim, Alsaidan, Goodwin, Li, Sulejmani, Han, Bai, Albers, Beharry, Zheng, Norris, Szulc, Bielawska, Lebedyeva, Pegan, Cai (bib31) 2017; 77 Xie, Guo, Lou (bib22) 2020; 65 Zhou, Liu, Liang, Zhang, Bi, Yang, He, Jin, Li, Yang, Fu, Zhang (bib10) 2020; 22 Tang, Xiong, Zhang, Wang, Wang, Wu, Wei, Mo, Hou, Shi, Xiong, Zhang, Gong, Liao, Xiang, Zhang, Zhou, Li, Li, Guo, Zeng (bib25) 2021; 40 Beermann, Piccoli, Viereck, Thum (bib9) 2016; 96 Liu, Zhao, Zhang, Shi (bib20) 2019; 19 Qi, Zhang, Wu, Xiao, Wang, Ma (bib14) 2015; 52 Bray, Ferlay, Soerjomataram, Siegel, Torre, Jemal (bib3) 2018; 68 Ma, Zhou, Liu, Wu, Yu, Zhu, Liu (bib13) 2018; 11 Salmena, Poliseno, Tay, Kats, Pandolfi (bib24) 2011; 146 Lian, Xiong, Yang, Bo, Gong, Wang, Wei, Tang, Li, Liao, Wang, Zhou, Xiang, Wu, Li, Li, Chen, Li, Guo, Zeng, Xiong (bib18) 2018; 37 Yang, Yang, Zhang, Liu, Wang, Hong, Yu, Zhou, Zeng (bib21) 2017; 18 Mai, Xiao, Shi, Zhou, Yang, Zhang, Weng, Zhao, Wang, Liu, Sun, Qin, Wang (bib27) 2019; 10 Chen, Lv, Zhan, Wang, You, Luo, You (bib12) 2020; 235 Liu, Chang, Liu, Cai, Zhang, Chen, Xie, Cao, Shao, Jia, Zheng, Liao, Chen, Ernberg, Vaughan, Adami, Huang, Zeng, Zeng, Ye (bib7) 2016; 25 Ren, Yang, Peng, Xu (bib28) 2020; 40 Wen, Lian, Ding, Hu, Xiao, Xiong, Yang (bib19) 2020; 17 Chen, Chan, Le, Blanchard, Sun, Ma (bib1) 2019; 394 Guo, Johnson, Deng, Liao, Guan, Nelson, Tang, Zheng, de The, O’Brien, Winkler, Zeng (bib6) 2009; 124 Tsao, Tsang, Lo (bib4) 2017; 372 Schmitz, Grote, Herrmann (bib23) 2016; 73 Yi, Ouyang, Wang, Li, Yang (bib17) 2019; 234 Setti Boubaker, Gurtner, Trabelsi, Manni, Ayed, Saadi, Naimi, Ksontini, Ayadi, Blel, Rammeh, Chebil, Piaggio, Ouerhani (bib29) 2020; 47 Tay, Rinn, Pandolfi (bib15) 2014; 505 Tano, Akimitsu (bib8) 2012; 3 Zheng, Li, Zhou, Lin, Zhang, Lv, Huang, Liu, Chen, He, Kou, Zhang, Wen, Li, Ma, Liu, Sun (bib16) 2019; 79 Wang, Zhang, Xu, Shi, Yang, Sun, Li (bib26) 2020; 52 Peng, Liu, Zheng, Wu, Liu (bib11) 2020; 24 Bray (10.1016/j.prp.2021.153540_bib3) 2018; 68 Xie (10.1016/j.prp.2021.153540_bib22) 2020; 65 Zheng (10.1016/j.prp.2021.153540_bib16) 2019; 79 Wang (10.1016/j.prp.2021.153540_bib26) 2020; 52 Salmena (10.1016/j.prp.2021.153540_bib24) 2011; 146 Ren (10.1016/j.prp.2021.153540_bib28) 2020; 40 Kim (10.1016/j.prp.2021.153540_bib31) 2017; 77 Tano (10.1016/j.prp.2021.153540_bib8) 2012; 3 Tsao (10.1016/j.prp.2021.153540_bib4) 2017; 372 Tay (10.1016/j.prp.2021.153540_bib15) 2014; 505 Liu (10.1016/j.prp.2021.153540_bib7) 2016; 25 Qi (10.1016/j.prp.2021.153540_bib14) 2015; 52 Chen (10.1016/j.prp.2021.153540_bib12) 2020; 235 Chen (10.1016/j.prp.2021.153540_bib1) 2019; 394 Lian (10.1016/j.prp.2021.153540_bib18) 2018; 37 Peng (10.1016/j.prp.2021.153540_bib11) 2020; 24 Mai (10.1016/j.prp.2021.153540_bib27) 2019; 10 Zhou (10.1016/j.prp.2021.153540_bib10) 2020; 22 Deng (10.1016/j.prp.2021.153540_bib30) 2018; 9 Ma (10.1016/j.prp.2021.153540_bib13) 2018; 11 Tang (10.1016/j.prp.2021.153540_bib25) 2021; 40 Tang (10.1016/j.prp.2021.153540_bib2) 2016; 374 Yi (10.1016/j.prp.2021.153540_bib17) 2019; 234 Liu (10.1016/j.prp.2021.153540_bib20) 2019; 19 Schmitz (10.1016/j.prp.2021.153540_bib23) 2016; 73 Yang (10.1016/j.prp.2021.153540_bib21) 2017; 18 Liu (10.1016/j.prp.2021.153540_bib5) 2017; 123 Setti Boubaker (10.1016/j.prp.2021.153540_bib29) 2020; 47 Guo (10.1016/j.prp.2021.153540_bib6) 2009; 124 Beermann (10.1016/j.prp.2021.153540_bib9) 2016; 96 Wen (10.1016/j.prp.2021.153540_bib19) 2020; 17 |
| References_xml | – volume: 65 start-page: 2863 year: 2020 end-page: 2872 ident: bib22 article-title: LncRNA ANCR promotes invasion and migration of gastric cancer by regulating FoxO1 expression to inhibit macrophage M1 polarization publication-title: Dig. Dis. Sci. contributor: fullname: Lou – volume: 79 start-page: 4612 year: 2019 end-page: 4626 ident: bib16 article-title: Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3 publication-title: Cancer Res. contributor: fullname: Sun – volume: 25 start-page: 1201 year: 2016 end-page: 1207 ident: bib7 article-title: Oral hygiene and risk of nasopharyngeal carcinoma-a population-based case-control study in China publication-title: Cancer Epidemiol. Biomark. Prev. contributor: fullname: Ye – volume: 37 start-page: 253 year: 2018 ident: bib18 article-title: Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway publication-title: J. Exp. Clin. Cancer Res. contributor: fullname: Xiong – volume: 19 start-page: 1112 year: 2019 ident: bib20 article-title: Silencing of long-non-coding RNA ANCR suppresses the migration and invasion of osteosarcoma cells by activating the p38MAPK signalling pathway publication-title: BMC Cancer contributor: fullname: Shi – volume: 22 start-page: 1025 year: 2020 end-page: 1039 ident: bib10 article-title: lncRNA RP11-624L4.1 is associated with unfavorable prognosis and promotes proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 pathway in NPC publication-title: Mol. Ther. Nucleic Acids contributor: fullname: Zhang – volume: 234 start-page: 19088 year: 2019 end-page: 19102 ident: bib17 article-title: Long noncoding RNA PTPRG-AS1 acts as a microRNA-194-3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1 publication-title: J. Cell. Physiol. contributor: fullname: Yang – volume: 40 year: 2020 ident: bib28 article-title: Predictive value of β-catenin in bladder cancer: a systematic review and meta-analysis publication-title: Biosci. Rep. contributor: fullname: Xu – volume: 11 start-page: 8399 year: 2018 end-page: 8408 ident: bib13 article-title: LncRNA ANCR promotes proliferation and radiation resistance of nasopharyngeal carcinoma by inhibiting PTEN expression publication-title: Onco Targets Ther. contributor: fullname: Liu – volume: 9 start-page: 1143 year: 2018 ident: bib30 article-title: NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway publication-title: Cell Death Dis. contributor: fullname: Liu – volume: 123 start-page: 2716 year: 2017 end-page: 2725 ident: bib5 article-title: Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area publication-title: Cancer contributor: fullname: Ye – volume: 124 start-page: 2942 year: 2009 end-page: 2947 ident: bib6 article-title: Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China publication-title: Int. J. Cancer contributor: fullname: Zeng – volume: 40 start-page: 307 year: 2021 end-page: 321 ident: bib25 article-title: circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma publication-title: Oncogene contributor: fullname: Zeng – volume: 3 start-page: 219 year: 2012 ident: bib8 article-title: Long non-coding RNAs in cancer progression publication-title: Front. Genet. contributor: fullname: Akimitsu – volume: 10 start-page: 819 year: 2019 ident: bib27 article-title: MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma publication-title: Cell Death Dis. contributor: fullname: Wang – volume: 505 start-page: 344 year: 2014 end-page: 352 ident: bib15 article-title: The multilayered complexity of ceRNA crosstalk and competition publication-title: Nature contributor: fullname: Pandolfi – volume: 17 start-page: 381 year: 2020 end-page: 394 ident: bib19 article-title: LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression publication-title: RNA Biol. contributor: fullname: Yang – volume: 146 start-page: 353 year: 2011 end-page: 358 ident: bib24 article-title: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? publication-title: Cell contributor: fullname: Pandolfi – volume: 47 start-page: 8819 year: 2020 end-page: 8830 ident: bib29 article-title: Uncovering the expression patterns and the clinical significance of miR-182, miR-205, miR-27a and miR-369 in patients with urinary bladder cancer publication-title: Mol. Biol. Rep. contributor: fullname: Ouerhani – volume: 73 start-page: 2491 year: 2016 end-page: 2509 ident: bib23 article-title: Mechanisms of long noncoding RNA function in development and disease publication-title: Cell. Mol. Life Sci. contributor: fullname: Herrmann – volume: 68 start-page: 394 year: 2018 end-page: 424 ident: bib3 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. contributor: fullname: Jemal – volume: 52 start-page: 1227 year: 2020 end-page: 1235 ident: bib26 article-title: Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn, respectively publication-title: Acta Biochim. Biophys. Sin. contributor: fullname: Li – volume: 394 start-page: 64 year: 2019 end-page: 80 ident: bib1 article-title: Nasopharyngeal carcinoma publication-title: Lancet contributor: fullname: Ma – volume: 24 start-page: 1437 year: 2020 end-page: 1450 ident: bib11 article-title: Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR-892b to up-regulate LPAR1 expression publication-title: J. Cell. Mol. Med. contributor: fullname: Liu – volume: 18 start-page: 95 year: 2017 end-page: 104 ident: bib21 article-title: LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression publication-title: Cancer Biomark. contributor: fullname: Zeng – volume: 235 start-page: 7757 year: 2020 end-page: 7768 ident: bib12 article-title: Silencing of long noncoding RNA SRRM2-AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK-mediated cGMP-PKG signaling pathway publication-title: J. Cell. Physiol. contributor: fullname: You – volume: 52 start-page: 710 year: 2015 end-page: 718 ident: bib14 article-title: ceRNA in cancer: possible functions and clinical implications publication-title: J. Med. Genet. contributor: fullname: Ma – volume: 77 start-page: 6950 year: 2017 end-page: 6962 ident: bib31 article-title: Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression publication-title: Cancer Res. contributor: fullname: Cai – volume: 96 start-page: 1297 year: 2016 end-page: 1325 ident: bib9 article-title: Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches publication-title: Physiol. Rev. contributor: fullname: Thum – volume: 374 start-page: 22 year: 2016 end-page: 30 ident: bib2 article-title: Global trends in incidence and mortality of nasopharyngeal carcinoma publication-title: Cancer Lett. contributor: fullname: Jia – volume: 372 year: 2017 ident: bib4 article-title: Epstein-Barr virus infection and nasopharyngeal carcinoma publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. contributor: fullname: Lo – volume: 73 start-page: 2491 issue: 13 year: 2016 ident: 10.1016/j.prp.2021.153540_bib23 article-title: Mechanisms of long noncoding RNA function in development and disease publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-016-2174-5 contributor: fullname: Schmitz – volume: 146 start-page: 353 issue: 3 year: 2011 ident: 10.1016/j.prp.2021.153540_bib24 article-title: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? publication-title: Cell doi: 10.1016/j.cell.2011.07.014 contributor: fullname: Salmena – volume: 17 start-page: 381 issue: 3 year: 2020 ident: 10.1016/j.prp.2021.153540_bib19 article-title: LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression publication-title: RNA Biol. doi: 10.1080/15476286.2019.1708547 contributor: fullname: Wen – volume: 24 start-page: 1437 issue: 2 year: 2020 ident: 10.1016/j.prp.2021.153540_bib11 article-title: Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR-892b to up-regulate LPAR1 expression publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.14823 contributor: fullname: Peng – volume: 9 start-page: 1143 issue: 12 year: 2018 ident: 10.1016/j.prp.2021.153540_bib30 article-title: NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway publication-title: Cell Death Dis. doi: 10.1038/s41419-018-1201-x contributor: fullname: Deng – volume: 18 start-page: 95 issue: 1 year: 2017 ident: 10.1016/j.prp.2021.153540_bib21 article-title: LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression publication-title: Cancer Biomark. doi: 10.3233/CBM-161715 contributor: fullname: Yang – volume: 372 issue: 1732 year: 2017 ident: 10.1016/j.prp.2021.153540_bib4 article-title: Epstein-Barr virus infection and nasopharyngeal carcinoma publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2016.0270 contributor: fullname: Tsao – volume: 124 start-page: 2942 issue: 12 year: 2009 ident: 10.1016/j.prp.2021.153540_bib6 article-title: Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China publication-title: Int. J. Cancer doi: 10.1002/ijc.24293 contributor: fullname: Guo – volume: 65 start-page: 2863 issue: 10 year: 2020 ident: 10.1016/j.prp.2021.153540_bib22 article-title: LncRNA ANCR promotes invasion and migration of gastric cancer by regulating FoxO1 expression to inhibit macrophage M1 polarization publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-019-06019-1 contributor: fullname: Xie – volume: 25 start-page: 1201 issue: 8 year: 2016 ident: 10.1016/j.prp.2021.153540_bib7 article-title: Oral hygiene and risk of nasopharyngeal carcinoma-a population-based case-control study in China publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-16-0149 contributor: fullname: Liu – volume: 37 start-page: 253 issue: 1 year: 2018 ident: 10.1016/j.prp.2021.153540_bib18 article-title: Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway publication-title: J. Exp. Clin. Cancer Res. doi: 10.1186/s13046-018-0918-9 contributor: fullname: Lian – volume: 10 start-page: 819 issue: 11 year: 2019 ident: 10.1016/j.prp.2021.153540_bib27 article-title: MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma publication-title: Cell Death Dis. doi: 10.1038/s41419-019-2060-9 contributor: fullname: Mai – volume: 374 start-page: 22 issue: 1 year: 2016 ident: 10.1016/j.prp.2021.153540_bib2 article-title: Global trends in incidence and mortality of nasopharyngeal carcinoma publication-title: Cancer Lett. doi: 10.1016/j.canlet.2016.01.040 contributor: fullname: Tang – volume: 40 issue: 9 year: 2020 ident: 10.1016/j.prp.2021.153540_bib28 article-title: Predictive value of β-catenin in bladder cancer: a systematic review and meta-analysis publication-title: Biosci. Rep. doi: 10.1042/BSR20202127 contributor: fullname: Ren – volume: 52 start-page: 710 issue: 10 year: 2015 ident: 10.1016/j.prp.2021.153540_bib14 article-title: ceRNA in cancer: possible functions and clinical implications publication-title: J. Med. Genet. doi: 10.1136/jmedgenet-2015-103334 contributor: fullname: Qi – volume: 52 start-page: 1227 year: 2020 ident: 10.1016/j.prp.2021.153540_bib26 article-title: Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn, respectively publication-title: Acta Biochim. Biophys. Sin. doi: 10.1093/abbs/gmaa111 contributor: fullname: Wang – volume: 96 start-page: 1297 issue: 4 year: 2016 ident: 10.1016/j.prp.2021.153540_bib9 article-title: Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches publication-title: Physiol. Rev. doi: 10.1152/physrev.00041.2015 contributor: fullname: Beermann – volume: 19 start-page: 1112 issue: 1 year: 2019 ident: 10.1016/j.prp.2021.153540_bib20 article-title: Silencing of long-non-coding RNA ANCR suppresses the migration and invasion of osteosarcoma cells by activating the p38MAPK signalling pathway publication-title: BMC Cancer doi: 10.1186/s12885-019-6335-4 contributor: fullname: Liu – volume: 234 start-page: 19088 issue: 10 year: 2019 ident: 10.1016/j.prp.2021.153540_bib17 article-title: Long noncoding RNA PTPRG-AS1 acts as a microRNA-194-3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.28547 contributor: fullname: Yi – volume: 47 start-page: 8819 year: 2020 ident: 10.1016/j.prp.2021.153540_bib29 article-title: Uncovering the expression patterns and the clinical significance of miR-182, miR-205, miR-27a and miR-369 in patients with urinary bladder cancer publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-020-05932-3 contributor: fullname: Setti Boubaker – volume: 505 start-page: 344 issue: 7483 year: 2014 ident: 10.1016/j.prp.2021.153540_bib15 article-title: The multilayered complexity of ceRNA crosstalk and competition publication-title: Nature doi: 10.1038/nature12986 contributor: fullname: Tay – volume: 11 start-page: 8399 year: 2018 ident: 10.1016/j.prp.2021.153540_bib13 article-title: LncRNA ANCR promotes proliferation and radiation resistance of nasopharyngeal carcinoma by inhibiting PTEN expression publication-title: Onco Targets Ther. doi: 10.2147/OTT.S182573 contributor: fullname: Ma – volume: 79 start-page: 4612 issue: 18 year: 2019 ident: 10.1016/j.prp.2021.153540_bib16 article-title: Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-19-0799 contributor: fullname: Zheng – volume: 123 start-page: 2716 issue: 14 year: 2017 ident: 10.1016/j.prp.2021.153540_bib5 article-title: Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area publication-title: Cancer doi: 10.1002/cncr.30643 contributor: fullname: Liu – volume: 394 start-page: 64 issue: 10192 year: 2019 ident: 10.1016/j.prp.2021.153540_bib1 article-title: Nasopharyngeal carcinoma publication-title: Lancet doi: 10.1016/S0140-6736(19)30956-0 contributor: fullname: Chen – volume: 68 start-page: 394 issue: 6 year: 2018 ident: 10.1016/j.prp.2021.153540_bib3 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21492 contributor: fullname: Bray – volume: 235 start-page: 7757 issue: 11 year: 2020 ident: 10.1016/j.prp.2021.153540_bib12 article-title: Silencing of long noncoding RNA SRRM2-AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK-mediated cGMP-PKG signaling pathway publication-title: J. Cell. Physiol. doi: 10.1002/jcp.29382 contributor: fullname: Chen – volume: 77 start-page: 6950 issue: 24 year: 2017 ident: 10.1016/j.prp.2021.153540_bib31 article-title: Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-17-0981 contributor: fullname: Kim – volume: 22 start-page: 1025 year: 2020 ident: 10.1016/j.prp.2021.153540_bib10 article-title: lncRNA RP11-624L4.1 is associated with unfavorable prognosis and promotes proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 pathway in NPC publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2020.10.017 contributor: fullname: Zhou – volume: 40 start-page: 307 year: 2021 ident: 10.1016/j.prp.2021.153540_bib25 article-title: circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma publication-title: Oncogene doi: 10.1038/s41388-020-01531-5 contributor: fullname: Tang – volume: 3 start-page: 219 year: 2012 ident: 10.1016/j.prp.2021.153540_bib8 article-title: Long non-coding RNAs in cancer progression publication-title: Front. Genet. doi: 10.3389/fgene.2012.00219 contributor: fullname: Tano |
| SSID | ssj0007041 |
| Score | 2.3615572 |
| Snippet | In our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal carcinoma... BACKGROUNDIn our previous study, we revealed that Antidifferentiation noncoding RNA (ANCR) promoted proliferation and radiation resistance of nasopharyngeal... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 153540 |
| SubjectTerms | ANCR Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans MicroRNAs - genetics MiR-4731-5p Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology NMT1 RNA, Long Noncoding - genetics |
| Title | Long noncoding RNA ANCR promotes migration, invasion, EMT progress and stemness of nasopharyngeal carcinoma cells via the miR-4731-5p/NMT1 axis |
| URI | https://dx.doi.org/10.1016/j.prp.2021.153540 https://www.ncbi.nlm.nih.gov/pubmed/34333213 https://search.proquest.com/docview/2557543673 |
| Volume | 224 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1tb9MwELa6TUJ8QbxT3mQkPtFlJPFL2o_VKAxEK9QVqXyK7NjZMuiLlnaCX8Ff5i520jI0BEhIVRRZdR37eXp3vpzvCHmOKdN4yHmgtUkCHhsR9EyeB0IYw42MQaNXRWyPk9G0-2rAB61WXSVr0_ZfkYY2wBpPzv4F2s2PQgPcA-ZwBdTh-ke4v8fiQbCnzxbVcZXxqN_pjw7HGIgFqNiyMytOHOq4usX8QpX-fjCcuHAtFH6VP31lZ5UkxGAPhfUO1Pm3-QmmIs6wBNF8MVMd9PyXnYtCVSbsrBgHPGFRIJYwhdFwEnXU16LcNoE_qNVpc0TG5xo69fkK3ImtjZccvzKFaXxWRSOe1s5l-6nIlde6GE-0rugIXNfFJsioilTAuN0vvtG7N-KoCa7zPrf63M2bmT7ako0M6BUylxjmwDrZLSPoKr1S8cI9die0f1EUzmdxBmoKk5bG0QFIfuESR13Kv32MY-FQMWarhX47ZC8GqQZCda__djB91yj-JKwKpTbPVr9Er8IJLw10lRl01TanMncmN8kNv0-hfUewW6Rl57fJtaGPxLhDviPPaMMzCjyjyDNa84w2PNunNcv2KXCM1hyjgDmtOUYXOf2ZY7ThGK04RoFjFDhGtzj2EhlGkWF3ycfXg8nhUeCLewQZE2wV2KQnjbVdIyTTEuxKLYW1mucM2hUYoQpMeym1TJQCI9SaiGVJbDMRS5MZMDLvkV2YpH1AKNfK9HKThPDhQksteiHPtYxkt6uEDdvkRb3W6dLlcEnr4MYzaFmmCEzqgGkTXqOReiPUGZcpUOd33Z7VyKUgoHFd1Nwu1mUKe_ZEcCYT1ib3HaTNUzDOGIsj9vDfBn1Erm_-Mo_J7up8bZ-QndKsn3pu_gAXHrp3 |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long+noncoding+RNA+ANCR+promotes+migration%2C+invasion%2C+EMT+progress+and+stemness+of+nasopharyngeal+carcinoma+cells+via+the+miR-4731-5p%2FNMT1+axis&rft.jtitle=Pathology%2C+research+and+practice&rft.au=Ma%2C+Xingkai&rft.au=Yuan%2C+Yifang&rft.au=Lu%2C+Jianbin&rft.au=Li%2C+Menglin&rft.date=2021-08-01&rft.pub=Elsevier+GmbH&rft.issn=0344-0338&rft.eissn=1618-0631&rft.volume=224&rft_id=info:doi/10.1016%2Fj.prp.2021.153540&rft.externalDocID=S0344033821002016 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0344-0338&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0344-0338&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0344-0338&client=summon |