Effects of copper on viability and functional properties of hippocampal neurons in vitro

Copper (Cu2+) is an essential metal presented in the mammalian brain and released from synaptic vesicles following neuronal depolarization. However, the disturbance of Cu2+ homeostasis results in neurotoxicity. In our study we performed for the first time a combined functional investigation of cultu...

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Bibliographic Details

Published in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 69; no. 5; pp. 259 - 264
Main Authors:	Kapkaeva, Marina R., Popova, Olga V., Kondratenko, Rodion V., Rogozin, Pavel D., Genrikhs, Elisaveta E., Stelmashook, Elena V., Skrebitsky, Vladimir G., Khaspekov, Leonid G., Isaev, Nickolay K.
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 14-06-2017
Subjects:	Animals Cell Survival - drug effects Copper - toxicity Hippocampal neurons Hippocampus - drug effects Long-Term Potentiation - drug effects LTP Mice Neurons - drug effects Spike Synaptic Transmission - drug effects Spike Copper toxicity LTP Hippocampal neurons
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