Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models

• Published in: Journal of ethnopharmacology Vol. 222; pp. 190 - 200
• Main Authors: De Sales, Igor Rafael Praxedes, Formiga, Rodrigo De Oliveira, Machado, Flávia Danniele Frota, Nascimento, Raphaela Francelino, Pessoa, Matheus Marley Bezerra, Barros, Monique Emanuela Frutuoso Xavier, Vieira, Giciane Carvalho, Gadelha, Francisco Allysson Assis Ferreira, Marinho, Alexsandro Fernandes, Barbosa Filho, José Maria, Júnior, Raimundo Fernandes De Araújo, Antunes, Aurigena Araújo, Batista, Leônia Maria
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10-08-2018
• Subjects: Antioxidant property, Cytoprotection, Animal models; Cissampelos sympodialis; Cytokines; Gastric ulcer; Menispermaceae; Natural products; Cissampelos sympodialis; Cytokines; Gastric ulcer; Natural products; Menispermaceae; Antioxidant property, Cytoprotection, Animal models
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2018.04.019

The leaves and roots of Cissampelos sympodialis (Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary infections, inflammation, asthma and gastrointestinal disorders.
The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated.
Cs-EtOHE and Cs-TAF presented a reduction in gastric mucosa lesions against ethanol, NSAIDs, hypothermic restraint-stress and gastric juice containment induced ulcer models. This activity is related to alkaloids present in the extract, and involves the participation of sulfhydryl compounds, nitric oxide, KATP channels, prostaglandins, decreased levels of IL-1β and TNF-α and increased levels of GSH and IL-10.
The data indicate gastroprotective activity, due to the participation of the cytoprotective, antioxidant and immunoregulatory mechanisms.
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