Growth hormone-releasing hormone (GHRH) promotes metastatic phenotypes through EGFR/HER2 transactivation in prostate cancer cells

The involvement of growth hormone-releasing hormone (GHRH) in several relevant processes that contribute to prostate cancer progression was analyzed. Firstly, we evaluated GHRH effects on cell proliferation and adhesion in human cancer prostate cell lines, LNCaP and PC3, by using specific assays (Br...

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Bibliographic Details
Published in:	Molecular and cellular endocrinology Vol. 446; pp. 59 - 69
Main Authors:	Muñoz-Moreno, Laura, Bajo, Ana M., Prieto, Juan C., Carmena, María J.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 05-05-2017
Subjects:	beta Catenin - metabolism Cell adhesion Cell Adhesion - drug effects Cell Cycle - drug effects Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects GHRH Growth Hormone-Releasing Hormone - pharmacology Humans Male Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phenotype Proliferating Cell Nuclear Antigen - metabolism Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptional Activation - drug effects Transcriptional Activation - genetics Vascular Endothelial Growth Factor A - secretion VEGF secretion Prostate cancer GHRH Cell migration Cell adhesion VEGF secretion
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