One pot synthesis of structurally different mono and dimeric Ni(II) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 41; no. 31; p. 9323
• Main Authors: Prabhakaran, R, Kalaivani, P, Poornima, P, Dallemer, F, Paramaguru, G, Vijaya Padma, V, Renganathan, R, Huang, R, Natarajan, K
• Format: Journal Article
• Language: English
• Published: England 21-08-2012
• Subjects: Biphenyl Compounds - chemistry; Cell Line, Tumor; Cell Survival - drug effects; Crystallography, X-Ray; DNA - metabolism; Free Radicals - chemistry; Humans; L-Lactate Dehydrogenase - metabolism; Ligands; Muramidase - metabolism; Nickel - chemistry; Nickel - pharmacology; Nitric Oxide - metabolism; Picrates - chemistry; Thiosemicarbazones - chemistry; Thiosemicarbazones - pharmacology
• DOI: 10.1039/c2dt12231f
• EISSN: 1477-9234

One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3 were obtained from the reaction between [NiCl(2)(PPh(3))(2)], 1,2-bis(diphenylphosphino)ethane, and [H(2)-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh(3))] (1) and [(Ni(Sal-tsc))(2)(μ-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2 and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions.