Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [(18)F]trifluoromethyl carbinols in good yields.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 49; no. 38; p. 4018
Main Authors:	van der Born, Dion, Herscheid, J Koos D M, Orru, Romano V A, Vugts, Danielle J
Format:	Journal Article
Language:	English
Published:	England 01-01-2013
Subjects:	Aldehydes - chemistry Chlorofluorocarbons, Methane - chemical synthesis Chlorofluorocarbons, Methane - chemistry Fluorine Radioisotopes - chemistry Ketones - chemistry Positron-Emission Tomography
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Description
Summary:	A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [(18)F]trifluoromethyl carbinols in good yields.
ISSN:	1364-548X
DOI:	10.1039/c3cc37833k