Modified Reference Point Index (mRPI) and a decision tree for deriving uncertainty factors: A practical approach to cumulative risk assessment of food contaminant mixtures

Risk assessment of chemical mixtures remains a challenging task in all areas of food and consumer safety. So far, no general method has been developed that is best suited to several subject areas (e.g. food contaminants, additives and supplements, plant protection products). Especially for mixtures...

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Bibliographic Details
Published in:	Food and chemical toxicology Vol. 134; p. 110812
Main Authors:	Vejdovszky, Katharina, Mihats, Daniela, Griesbacher, Antonia, Wolf, Josef, Steinwider, Johann, Lueckl, Johannes, Jank, Bernhard, Kopacka, Ian, Rauscher-Gabernig, Elke
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2019
Subjects:	Animals Austria Chemical mixtures Cumulative risk assessment Decision Trees Dietary Exposure Food contaminants Food Contamination Humans Limit of Detection Modified maximum cumulative ratio Modified reference point index Risk Assessment Uncertainty Uncertainty factor Austria maxHQ HI 3-MCPD PAT ZEN 3-ADON HBGV HQ AGES RPI BMDL CONTAM mRPI UB 15-ADON UF RPQ Food contaminants LOAEL Chemical mixtures TDI Modified maximum cumulative ratio mMCR GE Uncertainty factor LOD WHO/ICPS maxRPQ DON CAG LOQ Modified reference point index Cumulative risk assessment LB NOAEL PAH4 NIV MCR OTA RP
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