Paramagnetic relaxation based biosensor for selective dopamine detection

We report a new NMR relaxation time-based method for sensitive and selective dopamine detection using paramagnetic nanoparticles. The Fe(3+) species in the nanoparticles serves as both the contrast agent and the target recognition element. The results demonstrate that paramagnetic nanoparticles, sim...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 51; no. 57; p. 11425
Main Authors:	Ahmadov, Tevhide Ozkaya, Joshi, Padmanabh, Zhang, Jinnan, Nahan, Keaton, Caruso, Joseph A, Zhang, Peng
Format:	Journal Article
Language:	English
Published:	England 21-07-2015
Subjects:	Biosensing Techniques Cations - chemistry Contrast Media - chemistry Dopamine - analysis Dopamine - cerebrospinal fluid Edetic Acid - chemistry Humans Iron - chemistry Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Nanoparticles - chemistry Nanoparticles - ultrastructure Silanes - chemistry Silicon Dioxide - chemistry
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Summary:	We report a new NMR relaxation time-based method for sensitive and selective dopamine detection using paramagnetic nanoparticles. The Fe(3+) species in the nanoparticles serves as both the contrast agent and the target recognition element. The results demonstrate that paramagnetic nanoparticles, similar to the more widely used superparamagnetic nanoparticles, can be integrated into relaxation based detection schemes while avoiding the aggregation problem commonly associated with superparamagnetic nanoparticles.
ISSN:	1364-548X
DOI:	10.1039/c5cc02732b