Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat

•CUMS-induced depressive behaviors via COTR-microglia M1/M2-astrocytes/BDNF pathway.•CUMS elevated IL-17 and TGF-β1 concentrations in the hippocampus.•Minocycline improved depressive behaviors via anti-inflammation. Activated microglia-induced neuroinflammation can stimulate the hypothalamic- pituit...

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Bibliographic Details
Published in:	Behavioural brain research Vol. 356; pp. 348 - 357
Main Authors:	Zhang, Cai, Zhang, Yong-Ping, Li, Yu-Yu, Liu, Bai-Ping, Wang, Hao-Yin, Li, Kang-Wei, Zhao, Shannon, Song, Cai
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-01-2019
Subjects:	Animals Antidepressive Agents - pharmacology Anxiety Disorders - drug therapy Behavior Behavior, Animal Brain-Derived Neurotrophic Factor - metabolism Chronic unpredictable mild stress Cytokines Depression - drug therapy Depression - metabolism Disease Models, Animal Female Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Microglial M1 Minocycline Minocycline - pharmacology Neurotrophins Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Rats, Sprague-Dawley Stress, Psychological - drug therapy Stress, Psychological - metabolism Minocycline Chronic unpredictable mild stress Behavior Cytokines Neurotrophins Microglial M1
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