Human Polymorphonuclear Leukocytes: Demonstration of Microtubules and Effect of Colchicine

Microtubules are demonstrable in mature human polymorphonuclear leukocytes, even after prolonged incubation in vitro. These organelles are not seen after treatment with colchicine, which has various functional effects on these cells but does not inhibit phagocytosis.

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 156; no. 3774; pp. 521 - 522
Main Authors:	Malawista, Stephen E., Bensch, Klaus G.
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 28-04-1967
Subjects:	Animal cells Arthritis Colchicine - pharmacology Humans In Vitro Techniques Microscopy, Electron Microtubules Neutrophils Neutrophils - cytology Neutrophils - drug effects Organoids Phagocytosis
Online Access:	Get full text
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Description
Summary:	Microtubules are demonstrable in mature human polymorphonuclear leukocytes, even after prolonged incubation in vitro. These organelles are not seen after treatment with colchicine, which has various functional effects on these cells but does not inhibit phagocytosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.156.3774.521