Hempseed oil induces reactive oxygen species- and C/EBP homologous protein-mediated apoptosis in MH7A human rheumatoid arthritis fibroblast-like synovial cells

The medicinal efficacy of hempseed (Cannabis sativa L.), which is rich in polyunsaturated fatty acids, in atopic dermatitis, inflammation, and rheumatoid arthritis (RA) has been suggested for centuries. Hempseed has been used as a treatment for these diseases in Korean and Chinese folk medicine. The...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 154; no. 3; pp. 745 - 752
Main Authors:	Jeong, Mini, Cho, Jaewook, Shin, Jong-Il, Jeon, Yong-Joon, Kim, Jin-Hyun, Lee, Sung-Joon, Kim, Eun-Soo, Lee, Kyungho
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 03-07-2014
Subjects:	Apoptosis Apoptosis - drug effects Arthritis, Rheumatoid - pathology Cannabis - chemistry Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug ER stress Fibroblasts - cytology Fibroblasts - drug effects Hempseed oil Humans Plant Oils - chemistry Plant Oils - isolation & purification Plant Oils - pharmacology Polyunsaturated fatty acids Reactive Oxygen Species - metabolism Rheumatoid arthritis Seeds - chemistry Structure-Activity Relationship Synovial cell Synovial Membrane - cytology Synovial Membrane - drug effects Transcription Factor CHOP - metabolism Palmitic acid (PubChem CID: 985) Synovial cell Alpha-linolenic acid (PubChem CID: 5280934) Polyunsaturated fatty acids Rheumatoid arthritis Oleic acid (PubChem CID: 445639) ER stress Linoleic acid (PubChem CID: 5280450) Hempseed oil Apoptosis
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