Animal models of human disease: Inflammation

Animal models of human disease: Inflammation

Animals have been used as models to study inflammation and autoimmunity for more than 80 years. During that time it has been understood that although the use of such models is an important and necessary part of understanding human disease, they inevitably display significant differences from the hum...

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Published in:Biochemical pharmacology Vol. 87; no. 1; pp. 121 - 130
Main Author: Webb, David R.
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-01-2014
Subjects:
Animals
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - pathology
Autoimmune disease
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity - genetics
Disease Models, Animal
Humans
Inflammation
Inflammation - genetics
Inflammation - immunology
Inflammation - pathology
Inflammatory bowel disease
Microbiome
Multiple sclerosis
Rheumatoid arthritis
Sepsis
Inflammatory bowel disease
Multiple sclerosis
Rheumatoid arthritis
Autoimmune disease
Sepsis
Inflammation
Microbiome
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Abstract Animals have been used as models to study inflammation and autoimmunity for more than 80 years. During that time it has been understood that although the use of such models is an important and necessary part of understanding human disease, they inevitably display significant differences from the human disease state. Since our understanding of human inflammation and autoimmunity is necessarily incomplete, it may be concluded that the animal models will also be reflective of the state of knowledge regarding such diseases. Nevertheless, animal models of rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis have been successfully used to enhance the understanding of the human disease and have made significant contributions to the development of powerful new therapies. However, there are exceptions. One of the most persistent has been the study of sepsis where the animal models have been woefully inadequate in uncovering targets for drug discovery and have led to repeated clinical failures. As will be explained, only by using newly developed genomics tools has it been possible to uncover the differences between sepsis in mice and sepsis in man. It is concluded that approaches using the newer genomic and proteomic data derived from human tissues, will make possible the development of animal models with more predictive power as aids to drug discovery.
AbstractList Animals have been used as models to study inflammation and autoimmunity for more than 80 years. During that time it has been understood that although the use of such models is an important and necessary part of understanding human disease, they inevitably display significant differences from the human disease state. Since our understanding of human inflammation and autoimmunity is necessarily incomplete, it may be concluded that the animal models will also be reflective of the state of knowledge regarding such diseases. Nevertheless, animal models of rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis have been successfully used to enhance the understanding of the human disease and have made significant contributions to the development of powerful new therapies. However, there are exceptions. One of the most persistent has been the study of sepsis where the animal models have been woefully inadequate in uncovering targets for drug discovery and have led to repeated clinical failures. As will be explained, only by using newly developed genomics tools has it been possible to uncover the differences between sepsis in mice and sepsis in man. It is concluded that approaches using the newer genomic and proteomic data derived from human tissues, will make possible the development of animal models with more predictive power as aids to drug discovery.
Author Webb, David R.
Author_xml – sequence: 1
  givenname: David R.
  surname: Webb
  fullname: Webb, David R.
  email: dwebb@scripps.edu
  organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, GAC 1200, La Jolla, CA 92037, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23811309$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Inflammatory bowel disease
Multiple sclerosis
Rheumatoid arthritis
Autoimmune disease
Sepsis
Inflammation
Microbiome
Language English
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Snippet Animals have been used as models to study inflammation and autoimmunity for more than 80 years. During that time it has been understood that although the use...
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SubjectTerms Animals
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - pathology
Autoimmune disease
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity - genetics
Disease Models, Animal
Humans
Inflammation
Inflammation - genetics
Inflammation - immunology
Inflammation - pathology
Inflammatory bowel disease
Microbiome
Multiple sclerosis
Rheumatoid arthritis
Sepsis
Title Animal models of human disease: Inflammation
URI https://dx.doi.org/10.1016/j.bcp.2013.06.014
https://www.ncbi.nlm.nih.gov/pubmed/23811309
https://search.proquest.com/docview/1490763043
Volume 87
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