The maximum entropy production requirement for proton transfers enhances catalytic efficiency for β-lactamases

Movement of charges during enzyme catalytic cycle may be due to conformational changes, or to fast electron or proton transfer, or to both events. In each case, entropy production can be calculated using Terrel L. Hill's method, if relevant microscopic rate constants are known. When ranked by t...

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Bibliographic Details
Published in:	Biophysical chemistry Vol. 244; pp. 11 - 21
Main Authors:	Juretić, Davor, Bonačić Lošić, Željana, Kuić, Domagoj, Simunić, Juraj, Dobovišek, Andrej
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-01-2019
Subjects:	beta-Lactamases - genetics Catalysis Catalytic efficiency Directed Molecular Evolution Entropy Entropy production Enzyme evolution Evolution, Molecular Kinetics Optimal rate constants Proton transfer steps Protons β-lactamases β-lactamases Optimal rate constants Proton transfer steps Catalytic efficiency Entropy production Enzyme evolution
Online Access:	Get full text
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