Synthesis and characterization of 1,2-bis(2-(5-bromo-2-hydroxybenzilidenamino)-4-chlorophenoxy)ethane and its metal complexes: An experimental, theoretical, electrochemical, antioxidant and antibacterial study

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 118; pp. 632 - 642
• Main Authors: Ilhan, Salih, Baykara, Haci, Oztomsuk, Abdussamet, Okumus, Veysi, Levent, Abdulkadir, Salih Seyitoglu, M., Ozdemir, Sadin
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 24-01-2014
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antioxidant; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Bacteria - drug effects; Bacterial Infections - drug therapy; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Cyclic voltammetry; DFT; Electrochemical Techniques; Gaussian; Humans; Models, Molecular; Schiff base complexes; Schiff Bases - chemical synthesis; Schiff Bases - chemistry; Schiff Bases - pharmacology; Spectrum Analysis; Cyclic voltammetry; Gaussian; DFT; Antioxidant; Schiff base complexes; HF
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2013.08.069

[Display omitted]
•The1,2-bis(2-(5-bromo-2-hydroxybenzilidenamino)-4-chlorophenoxy)ethane synthesized.•New Cu(II) Ni(II), Co(II), Fe(III) V(III) and Zn(II) complexes synthesized.•The structures of metal complexes were characterized by different analysis.•In addition, antioxidant, theoretical NMR and cyclic voltammetry studies done.
A new Schiff base ligand was synthesized by reaction of 5-bromosalicylaldehyde with 1,2-bis(4-chloro-2-aminophenoxy)ethane. Then the Schiff base complexes were synthesized by the reaction of metal salts and the novel Schiff base. The molar conductivity properties of the complexes were studied and found out that the complexes are nonelectrolytes. The structures of the ligand and its metal complexes were characterized by elemental analysis, FT-IR, UV–VIS, magnetic susceptibility measurements, molar conductivity measurements, and thermal gravimetric analysis. In addition antioxidant, theoretical NMR studies and cyclic voltammetry of the complexes were done. Two methods namely metal chelating activity and diphenylpicrylhydrazyl (DPPH) radical scavenging method were used to determine the antioxidant activity, and antibacterial properties of the compounds were also studied.