Tracking the extramedullary PML-RARα-positive cell reservoirs in a preclinical model: Biomarker of long-term drug efficacy

Using an acute promyelocytic leukemia (APL) preclinical model, we show that oncogene–specific PCR (Polymerase Chain Reaction)-based assays allow to evaluate the efficacy of immunotherapy combining all-trans retinoic acid (ATRA) and a DNA-based vaccine targeting the promyelocytic leukemia-retinoic ac...

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Bibliographic Details
Published in:	Molecular and cellular probes Vol. 27; no. 1; pp. 1 - 5
Main Authors:	Pokorna, Katerina, Le Pogam, Carole, Chopin, Martine, Balitrand, Nicole, Reboul, Murielle, Cassinat, Bruno, Chomienne, Christine, Padua, Rose Ann, Pla, Marika
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2013
Subjects:	Animal model Animals APL ATRA Brain - cytology Gene Dosage Immunotherapy Kaplan-Meier Estimate Leukemia, Promyelocytic, Acute - mortality Leukemia, Promyelocytic, Acute - therapy Mice Mice, Transgenic MRD Neoplasm Proteins - therapeutic use Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - immunology Oncogene Proteins, Fusion - metabolism RT-qPCR Spleen - cytology Treatment Outcome Tretinoin - therapeutic use Vaccination Vaccines, DNA - therapeutic use Animal model ATRA APL RT-qPCR Vaccination MRD
Online Access:	Get full text
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