Non-inflammatory pancreatic cysts: from diagnosis to treatment (97 cases series)

ABSTRACT Objective: to describe the implications of the diagnosis and treatment of non-inflammatory pancreatic cysts in a series of patients. Methods: we included patients with pancreatic cysts ≥1.0 cm, excluding those with a presumptive diagnosis of a pseudocyst. Imaging tests, echoendoscopy, and h...

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Published in:Revista do Colégio Brasileiro de Cirurgiões Vol. 48
Main Authors: AMICO, ENIO CAMPOS, SALGADO, CAIO TRAJANO SIQUEIRA, ALVES, JOSÉ ROBERTO, LIGUORI, ADRIANO DE ARAÚJO LIMA, SOUSA, ROGÉRIO LACERDA
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Published: Colégio Brasileiro de Cirurgiões 2021
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Abstract ABSTRACT Objective: to describe the implications of the diagnosis and treatment of non-inflammatory pancreatic cysts in a series of patients. Methods: we included patients with pancreatic cysts ≥1.0 cm, excluding those with a presumptive diagnosis of a pseudocyst. Imaging tests, echoendoscopy, and histopathology determined the diagnosis of the type of cyst. We applied the guidelines of the International Association of Pancreatology, with some modifications, in patients with mucinous or indeterminate lesions. Results: 97 adult patients participated in the study. A cystic neoplasm of the pancreas was diagnosed in 82.5% of cases. Diagnosis was mainly made by magnetic resonance (46% of cases). The two most common diagnoses were intraductal papillary mucinous neoplasm (43.3%) and serous cystadenoma (26%). Twenty-nine patients underwent surgery (33.3%). The most common surgical procedure was distal pancreatectomy associated with splenectomy in 19 cases (65.5%). Among the operated patients, 11 were diagnosed with cancer. None of the followed, non-operated patients had a diagnosis of cancer. Conclusions: magnetic resonance showed good accuracy, particularly in the diagnosis of intraductal papillary mucinous neoplasm. The guidelines of the International Association of Pancreatology, as applied in this study, showed a negative predictive value for cancer of 100%. A development of better diagnostic tests can reduce the number of unnecessary operations. RESUMO Objetivo: descrever as implicações do diagnóstico e tratamento dos cistos não inflamatórios do pâncreas em série de pacientes. Metódos: foram incluídos pacientes com cisto de pâncreas ≥1,0cm excluindo aqueles com diagnóstico presuntivo de pseudocisto. Exames de imagem, ecoendoscopia e anatomia-patológica determinaram o diagnóstico do tipo de cisto. As diretrizes da Associação Internacional de Pancreatologia foram aplicadas, com algumas modificações, nos pacientes com lesões mucinosas ou indeterminadas. Resultados: noventa e sete pacientes adultos participaram do estudo. A neoplasia cística de pâncreas foi diagnosticada em 82,5% dos casos. O diagnóstico foi feito principalmente por ressonância magnética (46% dos casos). Os dois diagnósticos mais frequentes foram a neoplasia papilar intraductal mucinosa (43,3%), e o cistoadenoma seroso (26%). Vinte e nove pacientes foram submetidos a operação (33,3%). O procedimento cirúrgico mais comum foi a pancreatectomia corpo-caudal associada à esplenectomia em 19 casos (65,5%). Entre os pacientes operados, 11 tiveram o diagnóstico de câncer. Nenhum dos pacientes seguidos teve o diagnóstico de câncer. Conclusões: a ressonância magnética apresentou boa acurácia, particularmente no diagnóstico da neoplasia papilar intraductal mucinosa. As diretrizes da Associação Internacional de Pancreatologia da forma que foram aplicadas no presente estudo, mostraram valor preditivo negativo para o câncer de 100%. O desenvolvimento de estratégias diagnósticas com melhor acurácia podem reduzir o número de cirurgias desnecessárias.
AbstractList ABSTRACT Objective: to describe the implications of the diagnosis and treatment of non-inflammatory pancreatic cysts in a series of patients. Methods: we included patients with pancreatic cysts ≥1.0 cm, excluding those with a presumptive diagnosis of a pseudocyst. Imaging tests, echoendoscopy, and histopathology determined the diagnosis of the type of cyst. We applied the guidelines of the International Association of Pancreatology, with some modifications, in patients with mucinous or indeterminate lesions. Results: 97 adult patients participated in the study. A cystic neoplasm of the pancreas was diagnosed in 82.5% of cases. Diagnosis was mainly made by magnetic resonance (46% of cases). The two most common diagnoses were intraductal papillary mucinous neoplasm (43.3%) and serous cystadenoma (26%). Twenty-nine patients underwent surgery (33.3%). The most common surgical procedure was distal pancreatectomy associated with splenectomy in 19 cases (65.5%). Among the operated patients, 11 were diagnosed with cancer. None of the followed, non-operated patients had a diagnosis of cancer. Conclusions: magnetic resonance showed good accuracy, particularly in the diagnosis of intraductal papillary mucinous neoplasm. The guidelines of the International Association of Pancreatology, as applied in this study, showed a negative predictive value for cancer of 100%. A development of better diagnostic tests can reduce the number of unnecessary operations. RESUMO Objetivo: descrever as implicações do diagnóstico e tratamento dos cistos não inflamatórios do pâncreas em série de pacientes. Metódos: foram incluídos pacientes com cisto de pâncreas ≥1,0cm excluindo aqueles com diagnóstico presuntivo de pseudocisto. Exames de imagem, ecoendoscopia e anatomia-patológica determinaram o diagnóstico do tipo de cisto. As diretrizes da Associação Internacional de Pancreatologia foram aplicadas, com algumas modificações, nos pacientes com lesões mucinosas ou indeterminadas. Resultados: noventa e sete pacientes adultos participaram do estudo. A neoplasia cística de pâncreas foi diagnosticada em 82,5% dos casos. O diagnóstico foi feito principalmente por ressonância magnética (46% dos casos). Os dois diagnósticos mais frequentes foram a neoplasia papilar intraductal mucinosa (43,3%), e o cistoadenoma seroso (26%). Vinte e nove pacientes foram submetidos a operação (33,3%). O procedimento cirúrgico mais comum foi a pancreatectomia corpo-caudal associada à esplenectomia em 19 casos (65,5%). Entre os pacientes operados, 11 tiveram o diagnóstico de câncer. Nenhum dos pacientes seguidos teve o diagnóstico de câncer. Conclusões: a ressonância magnética apresentou boa acurácia, particularmente no diagnóstico da neoplasia papilar intraductal mucinosa. As diretrizes da Associação Internacional de Pancreatologia da forma que foram aplicadas no presente estudo, mostraram valor preditivo negativo para o câncer de 100%. O desenvolvimento de estratégias diagnósticas com melhor acurácia podem reduzir o número de cirurgias desnecessárias.
ABSTRACT Objective: to describe the implications of the diagnosis and treatment of non-inflammatory pancreatic cysts in a series of patients. Methods: we included patients with pancreatic cysts ≥1.0 cm, excluding those with a presumptive diagnosis of a pseudocyst. Imaging tests, echoendoscopy, and histopathology determined the diagnosis of the type of cyst. We applied the guidelines of the International Association of Pancreatology, with some modifications, in patients with mucinous or indeterminate lesions. Results: 97 adult patients participated in the study. A cystic neoplasm of the pancreas was diagnosed in 82.5% of cases. Diagnosis was mainly made by magnetic resonance (46% of cases). The two most common diagnoses were intraductal papillary mucinous neoplasm (43.3%) and serous cystadenoma (26%). Twenty-nine patients underwent surgery (33.3%). The most common surgical procedure was distal pancreatectomy associated with splenectomy in 19 cases (65.5%). Among the operated patients, 11 were diagnosed with cancer. None of the followed, non-operated patients had a diagnosis of cancer. Conclusions: magnetic resonance showed good accuracy, particularly in the diagnosis of intraductal papillary mucinous neoplasm. The guidelines of the International Association of Pancreatology, as applied in this study, showed a negative predictive value for cancer of 100%. A development of better diagnostic tests can reduce the number of unnecessary operations.
Author ALVES, JOSÉ ROBERTO
AMICO, ENIO CAMPOS
SALGADO, CAIO TRAJANO SIQUEIRA
LIGUORI, ADRIANO DE ARAÚJO LIMA
SOUSA, ROGÉRIO LACERDA
AuthorAffiliation 1 - Centro de Gastroenterologia e Endoscopia Digestiva de Natal, GASTROCENTRO - Natal - RN - Brasil
4 - Universidade Federal do Rio Grande do Norte (UFRN), Unidade de Diagnóstico por Imagem e Métodos Gráficos do Hospital Universitário Onofre Lopes - Natal - RN - Brasil
2 - Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Medicina Integrada - Natal - RN - Brasil
3 - Universidade Federal de Santa Catarina, Departamento de Cirurgia - Florianopolis - SC - Brasil
AuthorAffiliation_xml – name: 2 - Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Medicina Integrada - Natal - RN - Brasil
– name: 4 - Universidade Federal do Rio Grande do Norte (UFRN), Unidade de Diagnóstico por Imagem e Métodos Gráficos do Hospital Universitário Onofre Lopes - Natal - RN - Brasil
– name: 1 - Centro de Gastroenterologia e Endoscopia Digestiva de Natal, GASTROCENTRO - Natal - RN - Brasil
– name: 3 - Universidade Federal de Santa Catarina, Departamento de Cirurgia - Florianopolis - SC - Brasil
Author_xml – sequence: 1
  givenname: ENIO CAMPOS
  surname: AMICO
  fullname: AMICO, ENIO CAMPOS
  organization: Centro de Gastroenterologia e Endoscopia Digestiva de Natal, Brasil; Universidade Federal do Rio Grande do Norte, Brazil
– sequence: 2
  givenname: CAIO TRAJANO SIQUEIRA
  surname: SALGADO
  fullname: SALGADO, CAIO TRAJANO SIQUEIRA
  organization: Universidade Federal do Rio Grande do Norte, Brazil
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  givenname: JOSÉ ROBERTO
  orcidid: 0000-0002-0520-5190
  surname: ALVES
  fullname: ALVES, JOSÉ ROBERTO
  organization: Universidade Federal de Santa Catarina, Brazil
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  givenname: ADRIANO DE ARAÚJO LIMA
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  fullname: LIGUORI, ADRIANO DE ARAÚJO LIMA
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  article-title: Ana´lise comparativa entre colangiopancreatoressona
  publication-title: ABCD, arq. bras. cir. dig
  contributor:
    fullname: Costa DAPD
– volume: 45
  start-page: 870
  issue: 6
  year: 2016
  ident: ref4
  article-title: Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology, Carcinoembryonic Antigen, and Amylase in Intraductal Papillary Mucinous Neoplasm
  publication-title: Pancreas
  doi: 10.1097/MPA.0000000000000559
  contributor:
    fullname: Moris M
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Snippet ABSTRACT Objective: to describe the implications of the diagnosis and treatment of non-inflammatory pancreatic cysts in a series of patients. Methods: we...
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SubjectTerms Diagnosis
Digestive System Surgical Procedures
Original
Pancreas
Pancreatic Cyst
Therapy
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Title Non-inflammatory pancreatic cysts: from diagnosis to treatment (97 cases series)
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