Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population

Background/Objectives The unknown pathogenesis of periorbital hyperpigmentation makes its treatment difficult. Existing evidence links p53 and VEGFA genes with skin hyperpigmentation. This study was aimed at (i) identifying the clinical pattern of periorbital hyperpigmentation; and (ii) detecting th...

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Bibliographic Details
Published in:	Australasian journal of dermatology Vol. 60; no. 2; pp. e99 - e104
Main Authors:	Amini, Farahnaz, Thazin Oo, Naw May, Okechukwu, Patrick Nwabueze, Seghayat, Marjan Sadat, Ng, Edmond Siah Chye
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01-05-2019
Subjects:	Allergic rhinitis Asian Continental Ancestry Group - genetics Cross-Sectional Studies DNA sequencing Erythema - pathology Eyelid Diseases - genetics Eyelids - abnormalities Female Gene polymorphism Genotype Genotype & phenotype Humans Hyperpigmentation Hyperpigmentation - genetics Malaysia Male Melanins - metabolism P53 gene p53 Protein periorbital hyperpigmentation pigmentation, SNP Polymerase Chain Reaction Polymorphism, Single Nucleotide polymorphisms Population studies Rhinitis, Allergic - genetics Saliva Single-nucleotide polymorphism Skin Skin - metabolism Tumor Suppressor Protein p53 - genetics Vascular Endothelial Growth Factor A - genetics VEGFA gene Young Adult Malaysia VEGFA gene pigmentation, SNP periorbital hyperpigmentation P53 gene polymorphisms
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