N‐acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: The role of l‐cysteine and hydrogen sulphide

Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone formation; however, emerging evidence suggests several key differences between these processes. N‐acetylcysteine (NAC) displays antioxidant...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 237; no. 1; pp. 1070 - 1086
Main Authors:	Bourne, Lucie E., Patel, Jessal J., Davies, Bethan K., Neven, Ellen, Verhulst, Anja, D'Haese, Patrick C., Wheeler‐Jones, Caroline P. D., Orriss, Isabel R.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-01-2022
Subjects:	Acetylcysteine Acetylcysteine - pharmacology Antioxidants Arteries Arteries - metabolism Biomedical materials bone formation Bone growth Calcification Calcium phosphates Cell death Cysteine Deacetylation Glutathione Glutathione - metabolism Hydrogen sulfide Hydrogen Sulfide - metabolism Hydrogen Sulfide - pharmacology hydrogen sulphide l‐cysteine Molecular modelling Muscles N‐acetylcysteine Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteogenesis Physiology Smooth muscle Sulfides vascular calcification bone formation l-cysteine hydrogen sulphide vascular calcification N-acetylcysteine
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