Serum‐plasma matched metabolomics for comprehensive characterization of benign thyroid nodule and papillary thyroid carcinoma

Metabolomics offers a noninvasive methodology to identify metabolic markers for pathogenesis and diagnosis of diseases. This work aimed to characterize circulating metabolic signatures of benign thyroid nodule (BTN) and papillary thyroid carcinoma (PTC) via serum‐plasma matched metabolomics. A cohor...

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Bibliographic Details
Published in:	International journal of cancer Vol. 144; no. 4; pp. 868 - 876
Main Authors:	Huang, Feng‐Qing, Li, Jing, Jiang, Lin, Wang, Feng‐Xiang, Alolga, Raphael N., Wang, Ma‐Jie, Min, Wen‐Jian, Ma, Gaoxiang, Zhao, Yi‐Jing, Wang, Shi‐Lei, Yu, Yuan, Chen, Xiang, Zhu, Danxia, Zhu, Jun, Wang, Guangzhou, Xia, Tiansong, Sang, Jian‐Feng, Lai, Mao‐De, Li, Ping, Zhu, Wei, Qi, Lian‐Wen
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 15-02-2019 Wiley Subscription Services, Inc
Subjects:	Adolescent Adult Aged Amino acids Benign Betaine biomarkers Biomarkers, Tumor - blood Cancer Child Diagnosis, Differential Differential diagnosis Female Glutamic acid Glutamine Humans Inositol Lipid metabolism Liquid chromatography Male Medical research Metabolic pathways Metabolism Metabolites Metabolomics Metabolomics - methods Middle Aged Nodules non‐invasive diagnosis Papillary thyroid carcinoma Pathogenesis Phenotypes Plasma Proline Quadrupoles Statistical analysis Thyroid Thyroid cancer Thyroid Cancer, Papillary - blood Thyroid Cancer, Papillary - diagnosis Thyroid Cancer, Papillary - metabolism Thyroid Neoplasms - blood Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism thyroid nodule Thyroid Nodule - blood Thyroid Nodule - diagnosis Thyroid Nodule - metabolism Young Adult thyroid nodule papillary thyroid carcinoma metabolomics non-invasive diagnosis biomarkers
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